Experimental substantiation of the expediency of the combined use of piracetam and metformin for pharmacological correction of cognitive disorders in conditions of prolonged hyperglycemia

Authors

DOI:

https://doi.org/10.26641/2307-0404.2020.3.214647

Keywords:

alloxan-induced hyperglycemia, diabetic encephalopathy, cognitive deficit, metformin, piracetam

Abstract

Chronic hyperglycemia, insulin resistance, endothelial dysfunction, and disturbance of the integrity of the blood-brain barrier are considered as strategically important links in the development of cognitive deficits in diabetic encephalopathy. Taking this into account, one of the modern trends in the optimization of the treatment of cognitive impairments induced by prolonged hyperglycemia is the co-administration of agents with antihyperglycemic and nootropic activity, in particular, metformin with piracetam. It has been shown that under conditions of experimental alloxan-induced hyperglycemia, piracetam has insufficient nootropic potential for eliminating cognitive deficits. Metformin has a weak nootropic effect in short-term use in low doses, without exhibiting these properties in prolonged administration. When combined with piracetam, metformin potentiates its antiamnesic properties, which helps to restore cognitive functions impaired by hyperglycemia. It is assumed that the mechanisms of such synergism are mediated by a decrease in the content of early and late markers of the destruction of protein molecules, the level of stable nitric oxide metabolites in the cerebral cortex, as well as a significant limitation of the manifestations of ultrastructural destructive changes in hippocampal neurons with a simultaneous improvement in the state of its microvasculature. The obtained results indicate the expediency of the combined use of metformin with nootropic agents for the prevention or treatment of cognitive impairments that occur as a result of diabetes mellitus.

Author Biographies

А. E. Lievykh

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

N. S. Bondarenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

S. N. Dronov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

V. I. Mamchur

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

I. V. Tverdokhlib

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

V. I. Zhyliuk

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pharmacology and Clinical Pharmacology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

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Published

2020-10-05

How to Cite

1.
Lievykh АE, Bondarenko NS, Dronov SN, Mamchur VI, Tverdokhlib IV, Zhyliuk VI. Experimental substantiation of the expediency of the combined use of piracetam and metformin for pharmacological correction of cognitive disorders in conditions of prolonged hyperglycemia. Med. perspekt. [Internet]. 2020Oct.5 [cited 2024Jul.25];25(3):30-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/214647

Issue

Section

THEORETICAL MEDICINE