Treatment of aggressive (rapidly progressing) generalized periodontitis using systemic enzyme therapy in combination with osteoinductive medicines

Authors

DOI:

https://doi.org/10.26641/2307-0404.2020.3.214852

Keywords:

generalized periodontitis, aggressive periodontitis, systemic enzyme therapy, Wobenzym, recombinant morphogenetic protein, rhBMP-2, treatment of periodontitis

Abstract

The modern treatment strategy for various forms of generalized periodontitis includes the use of a wide arsenal of drugs, which in turn leads to an excessive drug load on the body, this actualizes the search and use of drugs that have a systemic effect. The aim of the study is to develop and study the effectiveness of the use of systemic enzyme therapy in the treatment of aggressive (rapidly progressing) generalized periodontitis. The work is based on the results of comprehensive clinical and laboratory studies of 61 patients with an aggressive form of generalized periodontitis, without concomitant pathologies (30 main groups and 31 comparison groups). A control group consisted of 20 healthy donor volunteers. We used standard clinical, paraclinical, laboratory diagnostic methods, supplemented by dental volumetric tomography. In patients of both observation groups, standard protocol therapy was used, in the comparison group supplemented pathogenic therapy, and in the main group – multienzyme drug (Wobenzym) and rhBMP-2 injections. A comparative analysis of clinical, paraclinical, and laboratory studies has shown that the use of systemic enzyme therapy supplemented with recombinant morphogenetic protein (rhBMP-2) in patients with aggressive (rapidly progressing) generalized periodontitis is comparable to that of standard polymedicine therapy supplemented with pathogenic therapy, and leads to a faster control (average 13.7±0.7 days) of an active inflammatory and destructive process, normalization of indices of local humoral immunity, cytokine profile, free radical oxidation and antioxidant defense system, achievement of clinical and radiological remission in more than 90% of patients.

Author Biographies

O. O. Gudaryan

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of surgical dentistry, implantology and periodontology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

I. S. Mashchenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of surgical dentistry, implantology and periodontology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

T. O. Kucherenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of surgical dentistry, implantology and periodontology
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

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Published

2020-10-05

How to Cite

1.
Gudaryan OO, Mashchenko IS, Kucherenko TO. Treatment of aggressive (rapidly progressing) generalized periodontitis using systemic enzyme therapy in combination with osteoinductive medicines. Med. perspekt. [Internet]. 2020Oct.5 [cited 2024Mar.4];25(3):144-52. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/214852

Issue

Section

CLINICAL MEDICINE