Influence of seasonality on vitamin D level in patients with HCV infection and healthy people

Authors

  • M.A. Nikolaychuk SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Infectious Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine, Ukraine https://orcid.org/0000-0002-9338-0772
  • L.R. Shostakovych-Koretskaya SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Infectious Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine, Ukraine https://orcid.org/0000-0002-3637-8457
  • I.V. Budayeva SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Infectious Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine, Ukraine https://orcid.org/0000-0003-4899-4799
  • S.V. Biletska SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine», Department of Infectious Diseases, V. Vernadsky str., 9, Dnipro, 49044, Ukraine; Medical Center “Unimed”, Mlodej Polski str., 7, Krakow, 30-131, Poland , Ukraine

DOI:

https://doi.org/10.26641/2307-0404.2021.1.228000

Keywords:

chronic viral hepatitis C, vitamin D, seasonal factor

Abstract

According to WHO, about 150-200 million people are currently infected with the HCV virus worldwide. Recently, in the professional literature, the number of publications on the role of vitamin D in patients with viral hepatitis C has increased as vitamin D metabolism occurs with the participation of the liver and its deficiency is associated with an increased risk of infectious diseases. The aim of this study was to investigate the effect of seasonal factor on vitamin D (25 hydroxycalciferol) levels in patients with chronic viral hepatitis C and healthy subjects. The study involved 100 patients in the registry of patients with chronic viral hepatitis in the Dnipropetrovsk region. The prevalence and deficiency of vitamin D in patients with chronic viral hepatitis C and conditionally healthy subjects at different times of the year were determined, which showed the presence or absence of a seasonal effect on serum 25(OH)D level. Patients were divided into two groups, depending on the time of the year (autumn-winter and spring-summer), in which the level of 25 (OH) D was determined. The serum was metabolised by vitamin D, which is synthesized by the liver – 25 hydroxycalciferol (25 (OH) D), an indicator of the supply of vitamin D to the human body. Vitamin D levels were evaluated according to the M.F. Holick classification. According to the level of vitamin D patients were divided into 3 groups (patients with normal level, insufficient (suboptimal) level and vitamin D deficiency). The results of the study showed no effect of seasonal factor on the level of 25 (OH) D in the serum of patients with chronic viral hepatitis C. Vitamin D levels are controlled by the time of the year: in spring and summer this indicator is normal, in autumn and winter – seasonal decrease in vitamin D.

References

Shostakovych-Koretskaya LR, Nikolaychuk MA, Budayeva IV, Shevchenko-Makarenko OP, Lytvin KYu, Biletska SV. [Comparative analysis pf vitamin D contents in patients with chronic viral hepatitis C and healthy]. Medicni perspectivi. 2019;24(4):94-101. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2019.4.189360

Abhimanyu, Coussens AK. The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease. Photochem Photobiol Sci. 2017 Mar 16;16(3):314-38. PMID: 28078341. doi: https://doi.org/10.1039/C6PP00329J.

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Wea¬ver CM. Evaluation, Treatment, and Prevention of Vitamin D Deficiency. [An Endocrine Society Clinical Practice Guideline]. J. Clin. Endocrinol. Metab. 2011;96(7):1911-30. doi: https://doi.org/10.1210/jc.2011-0385

Firke S. Janitor: Simple tools for examining and cleaning dirty data; 2018. Available from: https://cran.r-project.org/package=janitor.

Nikolaichuk M. Characteristics of biochemical values in patients with hcv infection before conducting antiviral therapy depending on vitamin D level. Modern Science – Moderní věda. Praha. Česká republika, Nemoros. 2020;1:111-7. Available from: https://drive.google.com/file/d/1n2EiCCOwFDHlUGOkqmh3_YNleymLsX_f/view

R Core Team R: A language and environment for statistical computing. R Foundation for Statis. Computing. Vienna: Austria; 2019. Av. from: http://www.R-project.org/

Tsuprykov O, Chen X, Hocher CF, Skoblo R, Lianghong Yin, Hocher B. Why should we measure free 25(OH) vitamin D? J Steroid Biochem Mol Biol. 2018 Jun;180:87-104. Epub 2017 Dec 5. PMID: 29217467. doi: https://doi.org/10.1016/j.jsbmb.2017.11.014

Published

2021-03-26

How to Cite

1.
Nikolaychuk M, Shostakovych-Koretskaya L, Budayeva I, Biletska S. Influence of seasonality on vitamin D level in patients with HCV infection and healthy people. Med. perspekt. [Internet]. 2021Mar.26 [cited 2024Nov.3];26(1):184-90. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/228000

Issue

Section

CLINICAL MEDICINE