The phenomenon of rosacea-rushes (theoretical aspects)

Authors

  • V.A. Bocharov Odessa National Medical University, department of dermatology and venereology, Valikhovsky Lane, 2, Оdessa, 65082, Ukraine, Ukraine https://orcid.org/0000-0002-9786-6665
  • V.V. Bocharova Odessa National Medical University, department of dermatology and venereology, Valikhovsky Lane, 2, Оdessa, 65082, Ukraine, Ukraine https://orcid.org/0000-0001-7346-770X
  • M.M. Lebediuk Odessa National Medical University, department of dermatology and venereology, Valikhovsky Lane, 2, Оdessa, 65082, Ukraine, Ukraine https://orcid.org/0000-0003-1427-0792
  • A.A.S. Sarayreh Medical Institute Sumy State University, department of neurosurgery and neurology with a course in psychiatry, narcology, dermatovenereology, occupational diseases, clinical immunology, allergology, Troitska str., 48, Sumy, 40003, Ukraine, Ukraine https://orcid.org/0000-0002-4485-3828
  • L.V. Kuts Medical Institute Sumy State University, department of neurosurgery and neurology with a course in psychiatry, narcology, dermatovenereology, occupational diseases, clinical immunology, allergology, Troitska str., 48, Sumy, 40003, Ukraine, Ukraine https://orcid.org/0000-0001-7081-194X

DOI:

https://doi.org/10.26641/2307-0404.2021.2.234490

Keywords:

rosacea, women, rush, centers of reproductive regulation

Abstract

According to the decisions of international scientific forums, the problem of phenomenon of rosacea (acne rosacea), a common dermatosis with numerous unexplained aspects of etiopathogenesis is a promising area of modern medical research. The aim of the study was theoretical substantiation of the essential features of the mechanisms of occurrence, development and clinical manifestations of the first signs of rosacea in women of reproductive age. The use of a systematic analytical methodical approach to assess the data of clinical and laboratory examinations of women with rosacea, conducted in different regions of the world, allowed to establish the originality of such manifestations of dermatosis as the appearance of unexpected rushes to limited areas of the face, accompanied by local redness and local heat areas of the skin differring significantly from similar rushes in other diseases or syndromes (menopause, migraine, etc.). It is established that the peculiarity of the relationship of these clinical characteristics (from English: rush, ruddy, redness, rosacea, reproductive age of women, reaction) allows to indicate the first signs of dermatosis as a phenomenon inherent in this disease Rush-Ruddy-Rosacea-Reproduce-Reaction (abbreviated – «5-R»), the key pathophysiological target of which (as well as the disease as a whole) is a disorder of a set of hierarchically dependent mechanisms of the evolutionarily determined motivational need to ensure reproductive function in women (both at the cellular level and extracellular structures of the ovaries, and at different levels of subcortical formations and centers of the cortex of the cerebral hemispheres). The phenomenon of rosacea rush is closely related to other phenomena of this dermatosis – hypersensitivity of bradykinin receptors, actinic elastosis, development of post erythematous telangiectasia. The prospect of further research on the problem of rosacea is to study the relationship of disorders in the functional systems of molecules of signaling compounds of different classes (hormones, eicosanoids, neuropeptides, kinins, cytokines and others) in the pathogenesis of the disease.

References

Dashko MO, Syzon OO. [The role of chronic stress, reactive and personal anxiety and some neuroendocrine, metabolic and immunological disorders in the pathogenesis of acne]. Ukrainskyi zhurnal dermatologii, venerologiyi, kosmetologii. 2019;2(73):7-17. Ukrainian. doi: https://doi.org/10.30978/UJDVK2019-2-7

Kolyadenko KV, Tkachyshyna KS. [28th Congress of the European Academy of Dermatology and Venereology]. Ukrayinskyi zhurnal dermatologii, vene¬rologii, kosmetologii. 2019;4(75):107-8. Ukrainian doi: https://doi.org/10.30978/UJDVK2019-4-107

Shirzad M, Hamedi J, Motevaseli E, Modarressi MH. Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast. Artif. Cells Nanomed. Biotechnol. 2018;46(1):27:1-11. doi: https://doi.org/10.1080/21691401.2018.1443274

Bocharov VA. Role in the development of rosacea special female genital center: Part I. Dermatovenerology and Cosmetology. 2020;1(4):18-35. doi: https://doi.org/10.26886/2523-6946.1(4)2020.2

Bocharova VV. Steroid hormone dysregulatory of rosacea: Part I Dermatovenerology and Cosmetology. 2020;1(4):3-17.

doi: https://doi.org/10.26886/2523-6946.1(4)2020.1

Diehl C. Peptides in cosmeceuticals. Ukrainian Journal of Dermatology, Venerology, Cosmetology. 2019;1(72):28-35. doi: https://doi.org/10.30978/UJDVK2019-1-28

Fiedler F, Stangl GI, Fiedler E, Taube K-M. Acne and Nutrition: A Systematic Review. Acta Derm. Venereol. 2017;97(1):7-9. doi: https://doi.org/10.2340/00015555-2450

Habif Thomas P. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. Sixth edition. St. Louis. Missouri: Elsevier; 2016.

Hofmann MA, Lehmann P. Physical modalities for the treatment of rosacea. J. Dtsch. Dermatol. Ges. 2016;14(6):38-43. doi: https://doi.org/10.1111/ddg.13144

Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc. Health Med. Ther. 2016;7:13-25. doi: https://doi.org/10.2147/AHMT.S55832

Barbara MR, Sewon K, Ana LC. Rosacea: Epidemiology, Pathogenesis, and Treatment. Dermato-Endocrinology. 2017;9(1):e1361574. doi: https://doi.org/10.1080/19381980.2017.1361574

Grossi E, Cazzaniga S, Crotti S, et al. The constellation of dietary factors in adolescent acne: a semantic connectivity map approach. J. Eur. Acad. Dermatol. Venereol. 2016;30(1):96-100. doi: https://doi.org/10.1111/jdv.12878

Published

2021-06-18

How to Cite

1.
Bocharov V, Bocharova V, Lebediuk M, Sarayreh A, Kuts L. The phenomenon of rosacea-rushes (theoretical aspects). Med. perspekt. [Internet]. 2021Jun.18 [cited 2024Oct.4];26(2):33-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/234490

Issue

Section

THEORETICAL MEDICINE