Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure
DOI:
https://doi.org/10.26641/2307-0404.2021.2.234498Keywords:
thyroglobulin, thyroid gland, rats, antigenAbstract
During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and ideas about its structural and functional restructuring in response to the body's immune system to various infections. The morpho-functional features of the thyroid gland of newborn animals after prenatal action of thyroid-nonspecific antigen (staphylococcal toxoid) have been experimentally established. In antigen-premiumed rats, the timing of folliculogenesis changes, as well as the size, distribution and immunohistochemical expression of antibodies to thyroglobulin, the functional state of thyrocytes and follicles compared to normal. The detected immunohistochemical changes indicate signs of morpho-functional immaturity of the organ with hypoactivity elements.
References
Dolgikh VT, Zolotov AN. Immunology. Moscow: Yurayt Publishing House. 2020. р. 248 Available from: https://urait.ru/book/immunologiya-455693
Zdor VV, Markelova EV, Geltser BI. [New participants in the violation of tolerance to thyroid antigens: to the concept of immunopathogenesis of autoimmune diseases of the thyroid gland (literature review)]. Medical immunology. 2016;18(3):209-20. Russian. doi: https://doi.org/10.15789/1563-0625-2016-3-209-220.
Matveishina TM, Shtanko IF. [Influence of intrauterine antigenic load on the intensity of distribution of receptors to sialospecific lectins in the structures of the mucous pharynx of rats]. Bulletin of problems of biology and medicine. 2016;129(2):214-9. Ukrainian.
Franceschi C, Ostan R, Mariotti S, Monti D, Vitale G. The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective. Endocrine reviews. 2019;40(5):1250-70.
doi: https://doi.org/10.1210/er.2018-00170
Tkachenko VI, Maksimets YaA. [Risk factors for the occurrence and progression of autoimmune diseases of the thyroid gland: a systematic analysis of data for the last 10 years]. Family medicine. 2017;5(73):20-25. Ukrainian.
Bliddal S, Nielsen CH, Feldt-Rasmussen U. Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Research. 2017;6:1776. doi: https://doi.org/10.12688/f1000research.11535.1
Harrington WE, Kakuru A, Jagannathan P. Malaria in pregnancy shapes the development of foetal and infant immunity. Parasite immunology. 2019;41(3):e12573. doi: https://doi.org/10.1111/pim.12573
Hong M, Bertoletti A. Tolerance and immunity to pathogens in early life: insights from HBV infection. Seminars in immunopathology. 2017;39(6):643-52. doi: https://doi.org/10.1007/s00281-017-0641-1
Kan B, Razzaghian HR, Lavoie PM. An Immunological Perspective on Neonatal Sepsis. Trends in molecular medicine. 2016;22(4):290-302. doi: https://doi.org/10.1016/j.molmed.2016.02.001
McLachlan SM, Rapoport B. Breaking to¬lerance to thyroid antigens: changing concepts in thyroid autoimmunity. Endocrine reviews. 2014;35(1):59-105.
doi: https://doi.org/10.1210/er.2013-1055
Marinò M, Latrofa F, Menconi F, Chiovato L, Vitti P. Role of genetic and non-genetic factors in the etiology of Graves' disease. Journal of endocrinological investigation. 2015;38(3):283-94. https://doi.org/10.1007/s40618-014-0214-2
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective / C. Franceschi et al. Endocr. Rev. 2019. Vol. 40, No. 5. P. 1250-1270. DOI: https://doi.org/10.1210/er.2018-00170
Liu P, Zheng J, Yang P, Wang X, Wei C, Zhang S, Feng S, Lan J, He B, Zhao D, Li J, Zhang Y. The immunologic status of newborns born to SARS-CoV-2-infected mothers in Wuhan, China. The Journal of allergy and clinical immunology. 2020;146(1):101-109.e1. doi: https://doi.org/10.1016/j.jaci.2020.04.038
Köhling HL, Plummer SF, Marchesi JR, Davidge KS, Ludgate M. The microbiota and autoimmunity: Their role in thyroid autoimmune diseases. Clinical immunology (Orlando, Fla.). 2017;183:63-74. doi: https://doi.org/10.1016/j.clim.2017.07.001
Qiu CC, Caricchio R, Gallucci S. Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens.Frontiers in immunology. 2019;10:2608. doi: https://doi.org/10.3389/fimmu.2019.02608
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Medicni perspektivi (Medical perspectives)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.