Algorithm of diagnostics of erectile dysfunction in patients with arterial hypertension and dynamics of arterial blood pressure against the background of androgenic deficiency

Authors

  • O.R. Vintoniv Regional Clinical Hospital Municipal Non-Commercial Enterprise of Ivano-Frankivsk Regional Council, Fedkovycha str., 91, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0002-2050-2206
  • I.R. Popadynets Ivano-Frankivsk National Medical University, Department of Internal Medicine N 1, Halytska str., 2, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0003-0307-3398
  • V.I. Hrodzinskyy Regional Clinical Hospital Municipal Non-Commercial Enterprise of Ivano-Frankivsk Regional Council, Fedkovycha str., 91, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0002-1718-8164
  • S.V. Melnyk Regional Clinical Hospital Municipal Non-Commercial Enterprise of Ivano-Frankivsk Regional Council, Fedkovycha str., 91, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0002-7973-7085
  • P.R. Herych Ivano-Frankivsk National Medical University, Department of Internal Medicine N 1, Halytska str., 2, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0002-7708-2150
  • I.M. Halipchak Regional Clinical Hospital Municipal Non-Commercial Enterprise of Ivano-Frankivsk Regional Council, Fedkovycha str., 91, Ivano-Frankivsk, 76000, Ukraine, Ukraine https://orcid.org/0000-0003-1033-7777

DOI:

https://doi.org/10.26641/2307-0404.2021.2.234638

Keywords:

erectile dysfunction, color Doppler imaging, androgen deficiency, arterial hypertension

Abstract

In recent years, the requirements for the level of the life quality have increased significantly; an integral part of it is the sexual harmony, which in men largely depends on sexual desire and erectile function. According to the results of modern scientific studies, there is no doubt that erectile dysfunction in men is closely connected with the cardiovascular diseases, obesity, diabetes mellitus and other comorbidities. This problem can also be caused by systematic psycho-emotional overload, deterioration of the environmental conditions, harmful factors of production, uncontrolled use of medicines, inflammatory processes in the genital organs, the growth of somatic diseases. The vast majority of works concerning “male menopause” is reduced to the effectiveness of hormone-replacement therapy in erectile dysfunction, while only few research works are devoted to the study of the connection between somatic pathology and androgen deficiency. There is a negative correlation between total testosterone level and systolic blood pressure. According to the research results of some scientists, it was found that 38% of patients with arterial hypertension had androgen deficiency, confirmed in the laboratory, which is significantly higher than in patients of the same age category with normal blood pressure. These dominant factors exert and increase the influence on each other, which must be taken into account in modern therapeutic practice. The study of the formation of comorbid conditions in men with low levels of androgens is of particular importance, as the knowledge of pathophysiological mechanisms can prevent their development and progression. The aim of this investigation was to study the state of penile vascular blood flow in men with arterial hypertension with erectile dysfunction, using color Doppler imaging with pharmacological induction of erection. The indicators of daily monitoring of arterial pressure and arterial stiffness in men with arterial hypertension of the II degree against the background of androgen deficiency or at normal testosterone levels and ways of correction of erectile dysfunction in these patients were also evaluated.

References

Barrientos G, Llanos P, Basualto-Alarcón C, Estrada M. Androgen-Regulated Cardiac Metabolism in Aging Men. Front Endocrinol. 2020;11:183-86. doi: https://doi.org/10.3389/fendo.2020.00316

Hackett G, Kirby M, Wylie K, et al. British Society for Sexual Medicine guidelines on the manage¬ment of erectile dysfunction in men. 2017. J Sex. Med. 2018;15:430-57. doi: https://doi.org/10.1016/j.jsxm.2018.01.023

Eriksson J, Haring R, Grarup N, et al. Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PloS One. 2017;12:e0176277:15. doi: https://doi.org/10.1371/journal.pone.0176277

Dominiczak A, Mancia G. Joint editorial for the International Society of Hypertension Guidelines. Hypertension. 2020;75:1334-57. doi: https://doi.org/10.1161/HYPERTENSIONAHA.120.15224

Elagizi A, Kohler TS, Lavie CJ. Testosterone and cardiovascular health. Mayo Clin Proc. 2018; 93:83-100. doi: https://doi.org/10.1016/j.mayocp.2017.11.006

World Health Federation. Elevating Hypertension on the Public Health Agenda. [Internet]. 2018. Available from: http://www.world-heart-federation.org

Gorpynchenko II, Hurzhenko YuM, Spiridonenko VV. A study of the effectiveness of the dietary supplement Libedor in men with erectile dysfunction. Men's Health. 2019;1(68):75-8. doi: https://doi.org/10.30841/2307-5090.1.2019.172855

Gorpynchenko II, Romanyuk MG Clinical protocols for providing medical care to patients with erectile dysfunction (project). Men's Health. 2016;3(58):11-22.

Klimov AN, Nikulcheva NG. Lipid and lipoprotein metabolism and its disorders. 3th. St. Petersburg: SPb Piter Com; 1999. p. 512.

Kloner RA. Testosterone Replacement Therapy: New Data on Efficacy and Cardiovascular Safety. J of Card Pharmac and Therape. 2017;22(1):54-55. doi: https://doi.org/10.1177/1074248416646938

Kovalenko VM, Dolzhenko MM, Nesukai YeH. Comparative characteristics of the cardiovascular disease prevention in Ukraine and Europe according to EUROASPIRE IV Data: a Hospital Line. Arterial Hypertens. 2016;1.45:29-34. doi: https://doi.org/10.22141/2224-1485.1.45.2016.74138

Luchitskyy VYe. The state of androgen supply and erectile function in men with type 2 diabetes mellitus with obesity. Men's Health. 2018;4(67):76-80. doi: https://doi.org/10.30841/2307-5090.4.2018.171746

Luchytskiy VE, Shelkovoy EA, Luchytskiy EV. Penile Doppler sonography in men with erectile dysfunction and type 2 diabetes. Endocrinology. 2016;1(21):45-50.

R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria; 2018. Available from: https://www.R-roject.org/

Williams В, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Europ Heart J. 2018;39(33):3021-104. doi: https://doi.org/10.1093/eurheartj/ehy339

Viigimaa M, Vlachopoulos C, Doumas M, Wolf J, Imprialos K, Terentes-Printzios D et al. Update of the position paper on arterial hypertension and erectile dysfunction. J Hypertens. 2020 Jul;38(7):1220-34. doi: https://doi.org/10.1097/HJH.0000000000002382

Viigimaa M, Vlachopoulos C, Lazaridis A, Doumas M. Management of erectile dysfunction in hypertension: Tips and tricks. World J of Cardiol. 2014 Sep 26; 6(9):908-15. DOI: https://doi.org/10.4330/wjc.v6.i9.908

Downloads

Published

2021-06-18

How to Cite

1.
Vintoniv O, Popadynets I, Hrodzinskyy V, Melnyk S, Herych P, Halipchak I. Algorithm of diagnostics of erectile dysfunction in patients with arterial hypertension and dynamics of arterial blood pressure against the background of androgenic deficiency. Med. perspekt. [Internet]. 2021Jun.18 [cited 2024Apr.15];26(2):119-25. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/234638

Issue

Section

CLINICAL MEDICINE