The role of epidural steroid injections in the treatment of pain in patients with degenerative changes in the lumbar spine

Authors

DOI:

https://doi.org/10.26641/2307-0404.2021.3.241938

Keywords:

epidural steroid injections, degenerative changes, spine

Abstract

Epidural steroid injections of the lumbar spine are a common interventional procedure that is used to alleviate radicular pain resulting from degenerative changes in the spine. Although several studies have compared epidural steroid injections with placebo with favorable outcomes, randomized controlled trials in this direction are needed. The purpose of the study was to evaluate the effectiveness of the use of epidural steroid injections in the treatment of pain in patients with degenerative lesions of the lumbar spine. During the study, 262 patients with degenerative lesions of the spine at one or two levels of the vertebral-motor segment (VMS) were selected. Epidurally transforaminally under fluoroscopic control all patients received steroid injections at the appropriate level (s) of VMS on the basis of the rehabilitation department of the Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine during 2017-2019. Of the 262 patients who received epidural steroid injections, 204 were able to reduce pain and avoid surgery within one year. However, 58 patients experienced only slight pain relief and were recommended surgical treatment. In our study, patients with negative results were offered surgery after 1.98 ESI procedures with an interval of 3.7 months. In the group of operated patients, the preliminary use of steroid injections did not bring relief by the results of Oswestry Disability Index (ODI) and Visual Analog scale (VAS), however, the condition of these patients improved significantly after surgery (p<0.05). The use of epidural injections is possible as a first-line therapy in patients with moderate functional limitations, which can subsequently be directed to surgery in the absence of a positive result.

References

Rudenko VM. [Mathematical statistics. Tutorial]. Tsentr uchbovoi literatury. Kyiv, 2012. p. 303. Ukrainian.

Benoist M, Boulu P, Hayem G. Epidural steroid injections in the management of low back pain with radiculopathy: Anupdate of their efficacy and safety. European Spine Journal. 2012;21:204-13. doi: http://dx.doi.org/10.1007/s00586-011-2007-z

Ekedahl H., Jönsson B., Annertz M., Frobell RB. The 1-Year Results of Lumbar Transforaminal Epidural Steroid Injection in Patients with Chronic Unilateral Radicular Pain: The Relation to MRI Findings and Clinical Features. Am J Phys Med Rehabil. 2017 Sep;96(9):654-62. doi: https://doi.org/10.1097/PHM.0000000000000730

Carette S, Leclaire R, Marcoux S, Morin F, Blai¬se GA, St Pierre A, Truchon R, Parent F, Levesque J, Bergeron V, Montminy P, Blanchette C. Epidural cortico¬steroid injections for sciatica due to herniated nucleus pulposus. New Engl J Med. 1997;336:1634-40. doi: https://doi.org/10.1056/NEJM199706053362303

Cohen SP, Bicket MC, Jamison D, Wilkinson I, Rathmell JP. Epidural steroids: A comprehensive, evi¬dence-basedreview. Regional Anesth and Pain Medicine. 2013;38:175-200. doi: https://doi.org/10.1097/AAP.0b013e31828ea086

Radcliff K, Kepler C, Hilibrand A, Rihn, Zhao W, Lurie J, Tosteson T, Vaccaro A, Albert T, Weinstein J. Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: A subgroup analysis of theSpine Patient Outcomes Research Trial. Spine (PhilaPa 1976). 2013;38:279-91. doi: http://dx.doi.org/10.1097/BRS.0b013e31827ec51f

McLain RF, Kapural L, Mekhail NA. Epidural steroid therapy for back and legpain: mechanisms of action and efficacy. The Spine Journal. 2005;5:191-201. doi: http://dx.doi.org/10.1016/j.spinee.2004.10.046

Mehta P, Syrop I, Singh JR, Kirschner J. Systematic Review of the Efficacy of Particulate Versus Nonparticulate Corticosteroids in Epidural Injec¬tions. PMR. 2017 May;9(5):502-12. Epub 2016 Nov 30. doi: https://doi.org/10.1016/j.pmrj.2016.11.008.

Quraishi NA. Transforaminal injection of corticosteroids for lumbar radiculopathy: Systematic review and meta-analysis. European Spine Journal. 2012;21:214-9. doi: http://dx.doi.org/10.1007/s00586-011-2008-y

Riew KD, Yin Y, Gilula L, Bridwell KH, Lenke LG, Lauryssen C, Goette K. The effect of nerve-root injections on theneed for operative treatment of lumbar radicular pain. A prospective, randomized, controlled, double-blind study. The Journal of Bone and Joint Surgery American Volume. 2000;82-A:1589-93. doi: https://doi.org/10.2106/00004623-200011000-00012

Radcliff K, Hilibrand A, Lurie JD, Tosteson TD, Delasotta L, Rihn J, Zhao W, Vaccaro A, Albert TJ, Weinstein JN. The impact of epidural steroid injections on theoutcomes of patients treated for lumbardisc herniation: A subgroup analysis of the SPORT trial. J Bone Joint Surg Am. 2012;94:1353-8. doi: http://dx.doi.org/10.2106/JBJS.K.00341

Vad VB, Bhat AL, Lutz GE, Cammisa F. Transforaminal epidural steroid injections in lumbosacral radiculopathy: Aprospective randomized study. Spine (PhilaPa 976). 2002;27:11-16. doi: https://doi.org/10.1097/00007632-200201010-00005

Viswanathan VK, Kanna RM, Farhadi HF. Role of transforaminal epidural injections or selective nerve root blocks in the management of lumbar radicular syn¬drome – A narrative, evidence-based review. J Clin Orthop Trauma. 2020 Sep-Oct;11(5):802-9. PMID: 32904233; PMCID: PMC7452348. doi: https://doi.org/10.1016/j.jcot.2020.06.004

Weinstein SM, Herring SA. Lumbar epidural steroid injections. The Spine Journal 2003;3:37S-44S. doi: http://dx.doi.org/10.1016/S1529-9430(02)00560-0

Young IA, Hyman GS, Packia-Raj LN, Cole AJ. The use of lumbar epidural/transforaminal steroids for managing spinal disease. The Journal of the American Academy of Orthopaedic Surgeons. 2007;15:228-38. doi: http://dx.doi.org/10.5435/00124635-200704000-00006

Published

2021-09-30

How to Cite

1.
Fishchenko I, Roy I, Kravchuk L. The role of epidural steroid injections in the treatment of pain in patients with degenerative changes in the lumbar spine. Med. perspekt. [Internet]. 2021Sep.30 [cited 2024Dec.21];26(3):55-60. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/241938

Issue

Section

CLINICAL MEDICINE