Environmental determinants of thyroid pathology

Authors

DOI:

https://doi.org/10.26641/2307-0404.2021.3.242253

Keywords:

thyroid gland, ecologically conditioned pathology, hypothyroidism, heavy metals, thyroid disruptors, radiаtion induced pathology, electromagnetic induced pathology

Abstract

Ecological situation of many countries, including Ukraine, is characterized by progressive anthropogenic and technogenic pollution, which causes growth in thyroid pathology, the share of which is significant in the structure of endocrine diseases. The main causes of thyroid disorders include iodine deficiency in the environment, exposure to a number of widely used che­micals (thyrodisruptors), heavy metal ions. A variety of physical environmental factors are important. A significant increase in thyroid cancer is frequently associated with local or general exposure to ionizing radiation. Prolonged exposure to electromagnetic fields can lead to disorders in the gland's homeostasis. The functional capacity of the gland is also impaired by unsanitary living conditions, some bacteria and viruses, and improper nutrition. High sensitivity of the gland to external impacts and high social significance of thyroid pathology give grounds to consider the morphofunctional condition of the thyroid gland as a marker of ecological well-being of the environment.

References

Antonenko AM, Korshun MM. [Environmental factors as a reason of thyroid gland pathology (analytical review, the first report)]. Environment & Health. 2016;3:74-79. Ukrainian. doi: https://doi.org/10.32402/dovkil2016.03.074

Antonenko AM, Korshun MM. [Environmental factors as the reasons of thyroid gland pathology risk (analytical literary review, the second report)]. Environment & Health. 2017;1:59-64. Ukrainian. doi: https://doi.org/10.32402/dovkil2017.01.059

Arzhanov IYu, Buniatov MR, Ushakovа GO. [The thyroid status of a conditionally healthy adult population of Prydniprovia]. Regulatory Mechanisms in Biosystems. 2017;8(4):554-8. Ukrainian. doi: https://doi.org/10.15421/021785

Biletska EM, Onul NM, Kalinicheva VV. [Comparative evaluation of bioprotective action of zinc in organic and inorganic form on osteotropism of lead in experimental conditions]. Medicni perspectivi. 2016;21(4):123-9. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2016.4.91481

Trachtenberg IM, Chekman IS, Linnik VO, Kaplunenko VG, Gulich MP, Biletska EM, et al. [Interaction of microelements: biological, medical, and social aspects]. Visn. Nac. Akad. Nauk Ukr. 2013;6:11-20. Ukrainian. doi: https://doi.org/10.15407/visn2013.06.011

Kosmynina NS, Gnateyko OZ, Pechenyk SO, Chaykovska GS. [Impact of ecologically unfriendly environment on the formation of thyroid pathology in children against iodine deficiency]. Child’s Health. 2014;1:45-48. Ukrainian. Available from: http://nbuv.gov.ua/UJRN/Zd_2014_1_10

Beletskaya EN, Onul NM, Glavatskaya VI, Anto¬nova EV, Golovkova TA. [Clinical hygienic substan¬tiation for the individual biocorrection of ecologically dependent conditions in the critical population groups in industrial areas of Ukraine]. Gigiena i Sanitariya. 2014;93(1):64-67. Russian. Available from: https://www.medlit.ru/journalsview/gigsan/view_journal/2014/1/

Kosmynina NS, Kech NR. [Comparative characteristics of thyroid function in children living in polluted iodine deficiency areas with different ways of reception of xenobiotics]. Actual Problems of Pediatrics, Obstetrics and Gynecology. 2014;2:69-72. Ukrainian. Available from: https://ojs.tdmu.edu.ua/index.php/act-pit-pediatr/article/view/4855/4486

Кravchenko VI. [Chornobyl accident and iodine deficiency as risk factors of thyroid pathology in popu¬lation of the affected regions of Ukraine]. The International Journal of Endocrinology (Ukraine). 2016;2:13-20. doi: https://doi.org/10.22141/2224-0721.2.74.2016.70911

Vorontsova ZA, Ushakov IB, Khadartsev AA, et al. [Morphofunctional correlations under the influence of pulsed electromagnetic fields]. Monograph. Editor Usha¬kov IB, Tula: Publishing House of Tula State University; Belgorod: Closed Joint-Stock Company "Belgorod Regional Printing House"; 2012. p. 368. Russian.

Balenko NV, Tsymbaliuk SM, Chernychenko IO, Lytvychenko OM, Hulchii NV, Ostash OM. [The role of carcinogenic metals in the formation of thyroid cancer morbidity in the population]. Environment & Health. 2017;3:14-21. Ukrainian. doi: https://doi.org/10.32402/dovkil2017.03.014

Ryabukha OI. [Some aspects of thyroid impact on the body state in normal and pathology conditions]. Actual problems of modern medicine: Bulletin of Uk¬rainian Medical Stomatological Academy. 2018;18(3):324-30. Ukrainian. Available from: https://cyberleninka.ru/article/n/deyaki-aspekti-vplivu-schitopodibnoyi-zalozi-na-stan-organizmu-v-umovah-normi-i-patologiyi

Ryabukha OI. [To the structural and functional preconditions of the emergence of thyroid pathology (literature review)]. Achievements of Clinical and Experimental Medicine. 2018;2:16-24. Ukrainian. doi: http://dx.doi.org/10.11603/1811-2471.2018.v0.i2.8903

Samykina EV, Zimina SV. [Genesial health state of the population in conditions struma endemia in the industrial megapolis]. Izvestia RAS Sam SC. 2009;11(1):914-6. Russian. Available from: https://cyberleninka.ru/article/n/sostoyanie-reproduktivnogo-zdorovya-naseleniya-v-usloviyah-zobnoy-endemii-v-promyshlennom-megapolise

Tronko MD, Pasteur IP, Stazenko OA, Giryavenko OYa. [30 years after the accident at the Сhornobyl NPP: review of publication in the journal "Endo¬cry¬nologia"]. Endokrynologia. 2016;21(2):166-76. Ukrainian. Available from: http://nbuv.gov.ua/UJRN/enkrl_2016_21_2_14

Chmil VD. [Organization and implementation of control in Ukraine for the content of dioxins and PCBS in food raw materials, food and feed in compliance with regulations European Union]. Modern Problems of Toxi¬cology, Food and Chemical Safety. 2015;3:87-103. Russian. Available from: http://protox.medved.kiev.ua/index.php/ru/categories/regulations/item/download/492_244e27ae2a7aa0c046b012ffb2243386

Andra SS, Makris K. Thyroid disrupting che¬micals in plastic additives and thyroid health. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012;30(2):107-51. doi: https://doi.org/10.1080/10590501.2012.681487

Du G, Shen O, Sun H, Fei J, Lu C, Song L, et al. Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays. Toxicol Sci. 2010;116:58-66. doi: https://doi.org/10.1093/toxsci/kfq120

Bajaj JK, Salwan P, Salwan S. Various possible toxicants involved in thyroid dysfunction: A review. J Clin Diagn Res. 2016;10(1):FE01-FE03. doi: https://doi.org/10.7860/JCDR/2016/15195.7092

Bost M, Martin A, Orgiazzi J. Iodine deficiency: epidemiology and nutritional prevention. Trace Elements in Medicine (Moscow). 2014;15(4):3-7. Available from: http://journal.microelements.ru/trace_elements_in_medicine/2014_4/3_15(4)_2014.pdf

La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020;16:45-57.

doi: https://doi.org/10.1038/s41574-019-0273-8

Li H, Li X, Liu J, Jin L, Yang F, Wang J, et al. Correlation between serum lead and thyroid diseases: Papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. Int J Environ Health Res. 2017;27:409-19. doi: https://doi.org/10.1080/09603123.2017.1373273

Demeneix BA. Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain develop¬ment. Eur Thyroid J. 2019;8:283-92. doi: https://doi.org/10.1159/000504668

Duntas LH, Stathatos N. Toxic chemicals and thyroid function: hard facts and lateral thinking. En¬docrine and Metabolic Disorders. 2015;16(4):311-8. doi: https://doi.org/10.1007/s11154-016-9331-x

Huang PC, Tsai CH, Liang WY, Li SS, Huang HB, Kuo PL. Early phthalates exposure in pregnant women is associated with alteration of thyroid hormones. PLoS One. 2016;11(7):e0159398. doi: https://doi.org/10.1371/journal.pone.0159398

Kunt H, Şentürk İ, Gönül Y, Korkmaz M, Ahsen A, Hazman Ö, et al. Effects of electromagnetic radiation exposure on bone mineral density, thyroid, and oxidative stress index in electrical workers. OncoTargets Ther. 2016;9:745-4. doi: https://doi.org/10.2147/OTT.S94374

Shahryar HA, Lotfi A, Ghodsi MB, Bonary AR. Effects of 900 MHz electromagnetic fields emitted from a cellular phone on the T3, T4, and cortisol levels in Syrian hamsters. Bull Vet Inst Pulawy. 2009;53(2):233-6. Available from: http://www.piwet.pulawy.pl/jvetres/images/stories/pdf/20092/20092233236.pdf

Eşmekaya MA, Seyhan N, Ömeroğlu S. Pulse modulated 900 MHz radiation induces hypothyroidism and apoptosis in thyroid cells: a light, electron microscopy and immunohistochemical study. Int J Radiat Biol. 2010;86(12):1106-16. doi: https://doi.org/10.3109/09553002.2010.502960

Ramhøj L, Hass U, Gilbert ME, Wood C, Svingen T, Usai D, et al. Evaluating thyroid hormone dis¬ruption: investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS). Sci Rep. 2020;10(1):2672. doi: https://doi.org/10.1038/s41598-020-59354-z

Gardell AM, von Hippel FA, Adams EM, Dillon DM, Petersen AM, Postlethwait JH, et al. Exoge¬nous iodide ameliorates perchlorate-induced thyroid pheno¬types in threespine stickleback. Gen Comp Endocrinol. 2017;243:60-69. doi: https://doi.org/10.1016/j.ygcen.2016.10.014

Li X, Gao Y, Wang J, Ji G, Lu Y, Yang D, et al. Exposure to environmental endocrine disruptors and hu¬man health. J Public Health Emerg. 2017;1:8. doi: https://doi.org/10.21037/jphe.2016.12.09

Helbing CC, van Aggelen G, Veldhoen N. Triclosan affects thyroid hormone-dependent metamorphosis in anurans. Toxicol Sci. 2011;119(2):417-8. doi: https://doi.org/10.1093/toxsci/kfq343

McMullen J, Ghassabian A, Kohn B, Trasande L. Identifying subpopulations vulnerable to the thyroid-blocking effects of perchlorate and thiocyanate. J Clin Endocrinol Metab. 2017;102(7):2637-45. doi: https://doi.org/10.1210/jc.2017-00046

Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, et al. Impact of drinking water fluoride on human thyroid hormones: A case-control study. Sci Rep. 2018;8:2674. doi: https://doi.org/10.1038/s41598-018-20696-4

Benedetti M, Zona A, Beccaloni E, Carere M, Comba P. Incidence of breast, prostate, testicular, and thyroid cancer in Italian contaminated sites with presence of substances with endocrine disrupting properties. Int J Environ Res Public Health. 2017;14(4):355-66. doi: https://doi.org/10.3390/ijerph14040355

Shrestha S, Parks CG, Goldner WS, Kamel F, Umbach DM, Ward MH, et al. Incident thyroid disease in female spouses of private pesticide applicators. Environ Int. 2018;118:282-92. doi: https://doi.org/10.1016/j.envint.2018.05.041

Ishikawa A, Kitano J. Ecological genetics of thyroid hormone physiology in humans and wild animals. In: Agrawal NK, editor. Thyroid Hormone. London: IntechOpen; 2012. p. 37-50. doi: https://doi.org/10.5772/45969

Yamashita S, Suzuki Sh, Suzuki Sa, Shimura H, Saenko V. Lessons from Fukushima: Latest findings of thyroid cancer after the Fukushima nuclear power plant accident. Thyroid. 2018;28(1):11-22. doi: https://doi.org/10.1089/thy.2017.0283

Buha A, Matović V, Antonijevic B, Bulat Z, Čurćić M, Renieri EA, et al. Overview of cadmium thyroid disrupting effects and mechanisms. Int J Mol Sci. 2018;19:1501. doi: https://doi.org/10.3390/ijms19051501

Portulano C, Paroder-Belenitsky M, Carrasco N. The Na+/I– symporter (NIS): Mechanism and medical impact. Endocr Rev. 2014;35(1):106-49. doi: https://doi.org/10.1210/er.2012-1036

Azizi F, Mehran L, Hosseinpanah F, Delshad H, Amouzegar A. Primordial and primary preventions of thyroid disease. Int J Endocrinol Metab. 2017;15(4):e57871. doi: https://doi.org/10.5812/ijem.57871

Rai G, Kumar A, Mahobiya P. The effect of radiation on thyroid gland. International Journal of Biology Research. 2018;3(1):217-22. Available from: https://www.researchgate.net/publication/323335927

Toki H, Wada T, Manabe Y, Hirota S, Higuchi T, et al. Relationship between environmental radiation and radioactivity and childhood thyroid cancer found in Fuku¬shima health management survey. Sci Rep. 2020;10:4074.

doi: https://doi.org/10.1038/s41598-020-60999-z

Gómez-Izquierdo J, Filion KB, Boivin J-F, Azoulay L, Pollak M, Yu OHY. Subclinical hypothy¬roidism and the risk of cancer incidence and cancer mortality: a systematic review. BMC Endocr Disord. 2020;20:83.

doi: https://doi.org/10.1186/s12902-020-00566-9

Gorini F, Iervasi G, Coi A, Pitto L, Bianchi F. The role of polybrominated diphenyl ethers in thyroid carcinogenesis: Is it a weak hypothesis or a hidden reality? From facts to new perspectives. Int J Environ Res Public Health. 2018;15(9):1834. doi: https://doi.org/10.3390/ijerph15091834

Drozd VM, Branovan I, Shiglik N, Biko J, Rei¬ners C. Thyroid cancer induction: Nitrates as independent risk factors or risk modulators after radiation exposure, with a focus on the Сhernobyl accident. Eur Thyroid J. 2018;7:67-74. doi: https://doi.org/10.1159/000485971

Oliveira KJ, Chiamolera MI, Giannocco G, Pazos-Moura CC, Ortiga-Carvalho TM. Thyroid function disruptors: from nature to chemicals. Journal of Molecular Endocrinology. 2019;62(1):R1-R19. doi: https://doi.org/10.1530/JME-18-0081

Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Benvenga S, et al. Vanadium pentoxide induces the secretion of CXCL9 and CXCL10 chemokines in thyroid cells. Oncol Rep. 2018;39:2422-6. doi: https://doi.org/10.3892/or.2018.6307

Hertz-Picciotto I, Berliner N, Bernstein W.B., Carvan III MJ, Chakravarti A, Dolinoy DC, et al. Veterans and Agent Orange: Update 11 (2018). Washin¬gton, DC: The National Academies Press; 2018. p. 738.

Waugh DT. Fluoride exposure induces inhibition of sodium/iodide symporter (NIS) contributing to impaired iodine absorption and iodine deficiency: Molecular mechanisms of inhibition and implications for Public Health. Int J Environ Res Public Health. 2019;16:1086. doi: https://doi.org/10.3390/ijerph16061086

Downloads

Published

2021-09-30

How to Cite

1.
Ryabukha O, Fedorenko V. Environmental determinants of thyroid pathology. Med. perspekt. [Internet]. 2021Sep.30 [cited 2024Nov.20];26(3):169-78. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/242253

Issue

Section

PREVENTIVE MEDICINE