The influence of parenteral influenza vaccination on local immunity indices and microbiota of oropharyngeal secretion in patients with chronic inflammatory diseases of the upper respiratory tract

Authors

  • D.I. Zabolotny SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0001-9429-4414
  • O.F. Melnikov SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0002-1261-8647
  • S.V. Timchenko SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0001-8308-4243
  • M.B. Sambur SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0002-9347-2829
  • O.G. Rylska SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0003-3990-7454
  • L.I. Volosevich SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0002-3840-724X
  • T.A. Zayets SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0002-4377-4810
  • M.D. Timchenko SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0002-2734-604X
  • I.V. Faraon SI “Institute of Otolaryngology named after prof. O.S. Kolomiychenko of National Academy of Medical Sciences of Ukraine”, Zoologichna str, 3, Kyiv, 03057, Ukraine https://orcid.org/0000-0003-1010-4308

DOI:

https://doi.org/10.26641/2307-0404.2021.4.248169

Keywords:

chronic inflammatory diseases of the upper respiratory tract,, microbiota, vaccination, influenza, local immunity

Abstract

When studying the effect of vaccines against influenza, attention is mainly paid to obtaining high titers of protective antibodies in the blood and reducing the incidence of respiratory infections among vaccinated people. At the same time, the changes  occurring in patient,s body from the factors of local specific and innate immunity remain insufficiently studied. The aim of the study was to determine the effect of parenteral influenza vaccination on the state of local immunity, cytology and microbiota of oropharyngeal secretion (OS) in patients with chronic inflammatory diseases of the upper respiratory tract. The study of immunological and microbiological parameters was performed in 32 patients with chronic inflammatory diseases of the upper respiratory tract, including 11 diagnosed with chronic rhinosinusitis, 9 – with chronic tonsillitis, 12 – with chronic pharyngitis, 3 and 12 weeks after vaccination with trivalent inactivated influenza-vaccine (PASTEUR, SA, France), which was administered intramuscularly. Single vaccination against influenza A and B has been shown to normalize reduced local humoral immunity indices, in particular sIgA and immune complexes concentrations, increase lymphocyte output to oropharyngeal secretions and cause a significant decrease in the representation of OS transient microflora without affecting the overall level of bacterial contamination. In both periods after the vaccination the reduced content of interferon-α in the OS of patients with chronic inflammatory diseases of the upper respiratory tract did not change. The obtained data allow to recommend vaccination against influenza virus in the period up to 3 months before the the beginning of mass infections as an effective means of stimulating the protective reactions of local immunity of oropha­rynx and nasopharynx mucous membranes in patients with chronic inflammatory diseases of the upper respiratory tract.

References

Antomonov MYu. [Mathematical processing and analysis of biomedical data]. Kyiv: Medinform. 2018. p. 579. Russian.

Grinevich YuA, Alferov AN. [Determination of immune complexes in the blood of cancer patients]. Lab. delo, 1981;(8):493-6. Russian.

Zabolotny DI, et al. [Study of oropharyngeal secretion in patients with chronic inflammatory and allergic diseases of the upper respiratory tract: guidlines]. Kyiv: AMNU, MOZ Ukraїni, UTS NMІ ta PLR; 2008. Ukrainian.

Hoult J, Krieg N, Snit P, editors. [Bergey's Keys to Bacteria. Volume one]. Moskva: Mir; 1997. p. 430. Russian.

Acosta PL, Byrne AB, Hijano DR, Talarico LB. Innate immune responses against human RNA viruses. Journal of Immunology Research [Internet]. 2020;2020(Article ID 1372494):27. doi: https://doi.org/10.1155/2020/1372494

De Benedictis FM, Bush A. Recurrent lower respiratory tract infections in children. BMJ [Internet]. 2018;12;362:k2698. doi: https://doi.org/10.1136/bmj.k2698

GBD 2015 LRI Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematicanalysis for the Global Burden of Disease Study 2015. Lancet Infect Dis. 2017;17(11):1133-61. doi: https://doi.org/10.1016/S1473-3099(17)30396-1

Goetzel RZ, Hawkins K, Ozminkowski RJ, Wang S. The health and productivity cost burden of the "top 10" physical and mental health conditions affecting six large U.S. employers in 1999. J Occup Environ Med. 2003;45(1):5-14. doi: https://doi.org/10.1097/00043764-200301000-00007

Hakansson AP, Orihuela CJ, Bogaert D. Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection. Physiol Rev. 2018;98(2):781-811. doi: https://doi.org/10.1152/physrev.00040.2016

Abreu RB, Clutter EF, Attari S, Sautto GA, Ross TM. IgA Responses Following Recurrent Influenza Virus Vaccination. Front Immunol [Internet]. 2020;11:902.

Feleszko W, Marengo R, Vieira AS, Ratajczak K, Butrón JLM. Immunity-targeted approaches to the mana¬gement of chronic and recurrent upper respiratory tract disorders in children. Clinical Otolaryngology. 2019;44(4):502-10. doi: https://doi.org/10.1111/coa.13335

Ramenzoni LL, Lehner MP, Kaufmann ME, Wiedemeier D, Attin T, Schmidlin PR. Oral Diagnostic Methods for the Detection of Periodontal Disease. Diagnostics (Basel). 2021;11(3):571. doi: https://doi.org/10.3390/diagnostics11030571

Theda C, Hwang SH, Czajko A, Loke YJ, Leong P, Craig JM. Quantitation of the cellular content of saliva and buccal swab samples. Sci Rep. 2018;8:6944. doi: https://doi.org/10.1038/s41598-018-25311-0

Smith AM, Huber VC. The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza. Viral Immunol. 2018;31(2):159-73. doi: https://doi.org/10.1089/vim.2017.0138

Wang TT, Bournazos S, Ravetch JV. Immunological responses to influenza vaccination: lessons for improving vaccine efficacy. Curr Opin Immunol. 2018;53:124-129. doi: https://doi.org/10.1016/j.coi.2018.04.026

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Published

2021-12-20

How to Cite

1.
Zabolotny D, Melnikov O, Timchenko S, Sambur M, Rylska O, Volosevich L, Zayets T, Timchenko M, Faraon I. The influence of parenteral influenza vaccination on local immunity indices and microbiota of oropharyngeal secretion in patients with chronic inflammatory diseases of the upper respiratory tract. Med. perspekt. [Internet]. 2021Dec.20 [cited 2024Dec.27];26(4):104-12. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/248169

Issue

Vol. 26 No. 4 (2021)

Section

CLINICAL MEDICINE

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