Charactirestics of vitamin D level in patients with atopic dermatitis

E. Garibeh; S.А. Bondаr; N.I. Tokarchuk; Y.V.  Vyzgha

doi:10.26641/2307-0404.2022.3.265954

Authors

E. Garibeh National Pirogov Memorial Medical University Vinnytsya, Pirogov st., 56, Vinnytsya, 21018, Ukraine https://orcid.org/0000-0002-5611-2074
S.А. Bondаr National Pirogov Memorial Medical University Vinnytsya, Pirogov st., 56, Vinnytsya, 21018, Ukraine https://orcid.org/0000-0001-5005-9420
N.I. Tokarchuk National Pirogov Memorial Medical University Vinnytsya, Pirogov st., 56, Vinnytsya, 21018, Ukraine https://orcid.org/0000-0001-6868-6596
Y.V. Vyzgha National Pirogov Memorial Medical University Vinnytsya, Pirogov st., 56, Vinnytsya, 21018, Ukraine https://orcid.org/0000-0002-3237-9962

DOI:

https://doi.org/10.26641/2307-0404.2022.3.265954

Keywords:

atopic dermatitis, vitamin D

Abstract

The peculiarity of the skin is that it acts not only as a place of synthesis of vitamin D, but also as an organ targeted for its biologically active form. The aim of our study was to analyze the level of vitamin D in patients with atopic dermatitis. There were examined 48 people aged between 18 to 55 years; they are residents of Vinnytsia and Vinnytsia region. Serum levels of vitamin D, total IgE and eosinophilic cationic protein (ECP) were determined in the subjects. The average level of vitamin D in the serum of patients with atopic dermatitis was 19.2 [11.3-25.4] ng/ml, which corresponded to a deficiency. Among those surveyed, vitamin D deficiency was found in 68.4±4.7% (n=26) while vitamin D insufficiency in 31.6±4.5% (n=12). The severe course of the disease prevailed among patients aged 18-40 years (63.33±8.79) % more than in the age group of 41 years and older, (36.67±8.8%, p<0.05; OR=2.98, S=0.53, 95% SI:1.04-8.52). The proportion of people with vitamin D deficiency and moderate severity of atopic dermatitis was 62.5% (n=10) with a median level of 14 [8.3–19] ng/ml, and patients with severe atopic dermatitis made up 90.9% (n=20) (χ²=4.6; p=0.023), in which the median level of vitamin D was 14 [8.3-19] ng/ml. Serum vitamin D levels were in the zone of deficiency in patients with moderate and severe atopic dermatitis. Vitamin D deficiency was significantly more common in the group of patients with elevated levels of allergic inflammation markers. A positive correlation of medium strength between the level of vitamin D and ECP in the serum of patients with atopic dermatitis (rs=0.53, p<0.001), was revealed.

References

Kang JW, Kim JH, Kim HJ, et al. Association of serum 25-hydroxyvitamin D with serum IgE levels in Korean adults. Auris, Nasus, Larynx. 2015;43(1):84-88. doi: https://doi.org/10.1016/j.anl.2015.06.010

Bergqvist C, Ezzedine K. Vitamin D and the skin: what should a dermatologist know? G Ital Dermatol Venereol. 2019;154(6):669-80. doi: https://doi.org/10.23736/S0392-0488.19.06433-2

Ferreira CES, Maeda SS, Batista MC, Lazaretti-Castro M, Vasconcellos LS, Madeira M, et al. Consensus – reference ranges of vitamin D [25(OH) D] from the Brazilian medical societies Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) and Brazilian Society of Endocrinology and Metabolism (SBEM). Jurnal Brasileiro de Patologia e Medicina Laboratorial. 2017;53(6):377-81. doi: http://www.dx.doi.org/10.5935/1676-2444.20170060

Galvão AA, Sena FA, Belitardo EM, Santana MB, Costa GN, Cruz BA, et al. Genetic polymorphisms in vita¬min D pathway influence 25(OH)D levels and are asso¬ciated with atopy and asthma. Allergy Asthma Clin Immunol. 2020;16:62-75. doi: https://doi.org/10.1186/s13223-020-00460-y

Han YY, Forno E, Celedón JC. Vitamin D insufficiency and asthma in a U.S. Nationwide study. J Allergy Clin Immunol Pract. 2017;5(3):790-796. doi: https://doi.org/10.1016/j.jaip.2016.10.013

Hemanth KK, Sathisha Upparahalli V, Anil M. Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases. Cytokine Growth Factor Rev. 2019;47:83-98. doi: https://doi.org/10.1016/j.cytogfr.2019.05.003

Thorisdottir D, Gunnarsdottir I, Vidarsdottir AG, Sigurdardottir S, Bryndis EB, Thorsdottir I. Infant Feeding, Vitamin D and IgE Sensitization to Food Aller-gens at 6 Years in a Longitudinal Icelandic Cohort. Nutrients. 2019;11(7):1690. doi: https://doi.org/10.3390/nu11071690

Amber KT, Chernyavsky A, Agnoletti AF, Coz-zani E, Grando SA. Mechanisms of pathogenic effects of eosinophil cationic protein and eosinophil‐derived neuro-toxin on human keratinocytes. Experimental Dermatology. 2018;27(12):1322-7. doi: https://doi.org/10.1111/exd.13782

Navarro-Triviño FJ, Arias-Santiago S, Gilaberte-Calzada Y. Vitamin D and the Skin: A Review for Derma¬tologists. Actas Dermosifiliogr. 2019;110(4):262-72. doi: https://doi.org/10.1016/j.ad.2019.04.001

Petrie A, Sabin C. Medical Statistics at a Glance. 4th edition. Wiley-Blackwell; 2019. ISBN: 978-1-119-16783-9.

Cheon BR, Shin JE, Kim YJ, Shim JW, Kim DS, Jung HL, Park MS, Shim JY. Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children. Korean J Pediatr. 2015; 58(3): 96-101. doi: https://doi.org/10.3345/kjp.2015.58.3.96

Amon U, Baier L, Yaguboglu R, Ennis M, Ho-lick MF, Amon J. Serum 25-hydroxy vitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis. Dermato-Endocrinology. 2018;10(1):e1442159-14. doi: https://doi.org/10.1080/19381980.2018.1442159

Zhang L, Zhang S, He C, Wang X. VDR Gene Polymorphisms and Allergic Diseases: Evidence from a Meta-analysis. Immunol Invest. 2020;49(1-2):166-77. doi: https://doi.org/10.1080/08820139.2019.1674325

Umar M, Sastry KS, Ali FA, Al-Khulaifi M, Wang E, Chouchane AI. Vitamin D and the Pathophy-siology of Inflammatory Skin Diseases. Skin Pharmaco-logy and Physiology. 2018;31(2):74-86. doi: https://doi.org/10.1159/000485132

Yuan K, Madu CO, Lu Y. Immunological Role of Vitamin D in Skin Diseases and Carcinoma. Oncome-dicine. 2017;2:52-60. doi: https://doi.org/10.7150/oncm.19262