The role of TLR-4 gene in the functioning of the natural human immune system and the immunopathogenesis of chronic hepatitis C (literature review)

T.I. Koval; L.M. Syzova; N.O. Pryimenko; A.Н. Sydorenko; M.V. Kulіsh; V.I. Ilchenko; N.P.  Lymarenko

doi:10.26641/2307-0404.2022.4.271169

Authors

T.I. Koval Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine http://orcid.org/0000-0003-2685-8665
L.M. Syzova Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine http://orcid.org/0000-0002-8335-3295
N.O. Pryimenko Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-8265-1143
A.Н. Sydorenko Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-9853-5892
M.V. Kulіsh Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine
V.I. Ilchenko Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-1451-442X
N.P. Lymarenko Poltava state medical university, Shevzenka str., 23, Poltava, 36011, Ukraine https://orcid.org/0000-0002-9858-8740

DOI:

https://doi.org/10.26641/2307-0404.2022.4.271169

Keywords:

TLR-4 gene, polymorphism, Asp299Gly, chronic hepatitis C, immunopathogenesis

Abstract

To date, despite significant advances in the study of the immunopathogenesis of chronic hepatitis C (CHC), many open questions remain in the diagnosis, prediction and course of treatment. In the context of the study of this infection, the Toll-like gene family of innate immune system receptors (TLRs) is of considerable interest. The article analyzes and summarizes the data of professional scientific sources on the role of the TLR-4 gene in the functioning of the natural human immune system, as well as Asp299Gly polymorphism of this gene in the immunopathogenesis of CHC. The relevance of the study is due to the fact that the innate immune system is crucial in the primary protection of the macroorganism from pathogens, the recognition of which largely depends on the TLRs receptor gene family, and genetic analysis is a modern and promising direction in personalized medicine. The importance of determining genetic markers lies in the fact that regardless of age and other factors of the external and internal environment, they carry information about the predisposition to various diseases, which can be used in the formation of a genetic passport. The data concerning the influence of the Asp299Gly polymorphism of the TLR4 gene on the immunopathogenesis of CHC are contradictory and require further investigation. An in-depth study of this issue will improve the therapeutic and diagnostic tactics of this disease based on a comprehensive assessment of the features of the immune response, which are caused by the carriage of the indicated polymorphism in the human genome.

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