Analysis of study rezults of biopsies of the vagina mucous membrane in women with recurrent genital prolapse.
DOI:
https://doi.org/10.26641/2307-0404.2014.2.28332Keywords:
genital prolapse, relapse, immunohistochemistry, vaginal mucosaAbstract
The study involved 53 women with recurrent genital prolapse. The average age of the women studied was 62,8±9,8 years, age of women of the control group was 57,2±6,3 years (p>0,05). Features of expression of estrogen and progesterone receptors levels, markers of cell proliferation and collagen in the biopsy of the vagina mucous membrane were estimated. In the vaginal mucosa of patients with recurrent prolapse expression of Ki-67 markers of proliferative activity was not established. According to the study general lowering of estrogen receptors by 76,2% in patients with recurrent genital prolapse was established, whereas in patients of the control group level of estrogen receptors in the unchanged epithelium and stroma was positive in 100% of cases. In patients with recurrent genital prolapse the decrease of expression of progesterone receptors by 83,4% was identified.References
Антомонов М.Ю. Математическая обработка и анализ медико-биологических данных. – К.: Изд-во „Малий друк”, 2006. – 558 с.
Гаспарян С.А. Дисплазия соединительной ткани (ДСТ) как причина развития пролапса гениталий / С.А. Гаспарян, Е.П. Афанасова, Л.В. Стариченко // Журнал акушерства и женских болезней. – 2009. – Т. 58, №5. – С. М29–М30.
Дисплазия соединительной ткани / под ред. Т.И. Кадуриной, В.Н. Горбуновой. – Санкт–Петербург: Элби, 2009. – 714 с.
Петров С.В. Руководство по иммуногистохимической диагностике опухолей человека / С.В. Петров, Н.Т. Райхлин. – Казань, 2004. – 452 с.
Применение малоинвазивных технологий в лечении осложненных форм пролапса гениталий / А.А. Попов, Т.Н. Мананникова, Г.Г. Шагинян [и др.] // Акушерство и гинекология. – 2004. – № 3. – С. 32–34.
Профілактика постгістеректомічного пролапсу під час трансабдомінальної екстирпації матки – новий підхід / В.Н. Запорожан, А.А. Процепко, М.Н. Дра¬чев¬ская [та ін.] // Репродуктивное здоровье женщины. – 2004. – №1(17). – С. 82–86.
Роль дисплазии соединительной ткани в па¬тогенезе пролапса гениталий и недержании мочи / С.Н. Буянова [и др.] // Рос. вестник акушера–гинеколога. – 2005. – №5 – С. 19–23.
Семенюк А.А. Лечение больных с урогенитальным пролапсом и недержанием мочи / А.А. Семенюк, Н.Н. Битюков, И.В. Поспелов // Урология. – 2006. – №1. – С. 61–64.
Смирнов А.Б. Сравнительная оценка методов хирургической коррекции ректоцеле / А.Б. Смирнов, В.В. Хворов // Хирургия. – 2006. – № 10. – С. 22–26.
Современный подход к коррекции ректоцеле у гинекологических больных с пролапсом гениталий / А.А. Попов [и др.] / Рос. вестник акушера–гинеколога. – 2006. – Т.6, № 2. – С. 38–40.
Сухих Г.Т. Поиск этиологических факторов пролапса гениталий / Г.Т. Сухих, А.Ю. Данилов, Д.А. Боташева // Рос. вестник акушера–гинеколога. – 2010. – Т. 10, № 5. – С. 28–32.
Функциональные нарушения при выраженных проявлениях пролапса гениталий / В.В. Бахаев, В.Э. Горин, В.Э. Гюнтер [и др.] // Журнал акушерства и женских болезней. – 2009. – Т. 58, № 5. – С. М17–М18.
De Lancey J.O. The hidden epidemic of pelvic floor dysfunction: achievable goals for improved prevention and treatment / J.O. De Lancey // Am. J. Obstet. Gynecol. – 2005. – Vol. 192. – P. 1488–1495.
Diez–Itza I. Risk factors for the recurrence of pelvic organ prolapse after vaginal surgery: a review at 5 years after surgery / I. Diez–Itza, I. Aizpitarte, A. Becerro // Int. Urogynecol. J. Pelvic Floor Dysfunct. – 2007. – Vol. 18, N 11. – P. 1317–1324.
Fialkow M.F. Incidence of recurrent pelvic organ prolapse 10 years following primary surgical management: a retrospective cohort study / M.F. Fialkow, K.M. Newton, N.S. Weiss // Int. Urogynecol. J. Pelvic Floor Dysfunct. – 2008. – Vol. 19, N 11. – P. 1483–1487.
Incidence of pelvic floor repair after hysterectomy: A population–based cohort study / R.E. Blandon, A.E. Bharucha, L.J. Melton [et al.] // Am. J. Obstet. Gynecol. – 2007. – Vol. 197, N 6. – P. 664.
Jeon M.J. Risk factors for the recurrence of pelvic organ prolapse / M.J. Jeon, S.M. Chung, H.J. Jung // Gynecol. Obstet. Invest. – 2008. – Vol. 6, N 66 (4). – P. 268–273.
Long–term results of the anterior Delorme's operation in the management of symptomatic rectocele / S. M. Abbas [et al.] // Dis. Colon Rectum. – 2005. – Vol. 48. – P 317–322.
Medina C.A. Wide genital hiatus is a risk factor for recurrence following anterior vaginal repair / C.A. Me¬dina, K. Candiotti, P. Takacs // Int. J. Gynaecol. Obstet. – 2008. – Vol. 101, N2. – P. 184–187.
Primary surgery of genital prolapse: a shift in treatment tradition / K. Crafoord, A. Sydsjo, K. Nilsson, P. Kjolhede // Acta. Obstet. Gynecol. Scand. – 2006. – Vol. 85, N9. – P. 1104–1108.
Risk factors for prolapse recurrence after vaginal repair / J.L. Whiteside, A.M. Weber, L.A. Meyn [et al.] // Am. J. Obstet. Gynecol. – 2004. – Vol. 191. – P. 1533–1538.
Shan-Rong Shi. Standardization of Immuno¬histo¬chemistry for Formalin-fixed, Paraffin-embedded Tissue Sections Based on the Antigen-retrieval Technique: From Experiments to Hypothesis / Shan-Rong Shi, Cheng Liu, Clive R. Taylor // J. Histochemistry Cyto¬chemistry. – 2007. – Vol. 55, N2. – Р. 105–109.
The relationship of vaginal prolapse severity to symptoms and quality of life /G.A. Digesu [et al.] // BJOG. – 2005. – Vol. 112. – P. 971–976.
Antomonov MY. [Mathematical processing and analysis of biomedical data]. Kiyv. 2006;558. Ukrainian.
Gasparyan SA, Afanasova EP, Starichenko LV. [Connective tissue dysplasia (CTD) as a cause of genital prolapse]. J. of obstetrics and female diseasis. 2009;58(5):М29–М30. Russian.
Kadurina TI, Gorbunova VN. [Connective tissue dysplasia]. Saint-Petersburg’s: Elbi; 2009;714. Russian.
Petrov SV, Rayhlin NT. [Guidelines for immunohistochemical diagnosis of human tumors]. Kazan. 2004;452. Russian.
Popov AA, Mananikova TN, Shaginyan GG. [Application of little invasive technologies in the treatment of the complicated forms of genital prolapse]. Obst. and gyn. 2004;3:32–34. Russian.
Zaporozhan VN, Procepko AA, Drachevskaya MN. [Prevention of prolapse after hysterectomy during transabdominal hysterectomy - a new approach]. Repro¬ductive health of woman. 2004;1(17): 82–86. Ukrainian.
Bujanova SN. [Role of connective tissue dysplasia in the pathogenesis of prolapse and incontinence]. Russian announcer of acc.-gyn. 2005;5:19–23. Russian.
Semenuk AA, Bitukov NN, Pospelov IV. [Treatment of patients with urogenital prolapse and uri¬nary incontinence]. Urology. 2006;1:61–64. Russian.
Smirnov AB, Khvorov VV. [Comparative estimation of methods of surgical correction of rectocele]. Surgery. 2006;10:22–26. Russian.
Popov AA. [The modern approach to the correction of rectocele in gynecological patients with genital prolapse]. Russian announcer of acc.-gyn. 2006;6(2):38–40. Russian.
Suhih GT, Danilov AY, Botasheva DA. [Search for etiological factors of genital prolapse]. Russian announcer of acc.-gyn. 2010;10(5):28–32. Russian.
Bachaev VV, Gorin VE, Gunter VE. [Functional violations in expressed manifestations of genital prolapse]. J. of obstetrics and female diseasis. 2009;58(5):М17–М18. Russian.
De Lancey JO. The hidden epidemic of pelvic floor dysfunction: achievable goals for improved prevention and treatment. Am J. Obstet Gynecol. 2005;192:1488–95.
Diez–Itza I, Aizpitarte I, Becerro A. Risk factors for the recurrence of pelvic organ prolapse after vaginal surgery: a review at 5 years after surgery. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(11):1317–24.
Fialkow MF, Newton KM, Weiss NS. Incidence of recurrent pelvic organ prolapse 10 years following primary surgical management: a retrospective cohort study. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(11):1483–87.
Blandon RE, Bharucha AE, Melton LJ. Incidence of pelvic floor repair after hysterectomy: A population–based cohort study. Am J Obstet Gynecol. 2007;197(6):664.
Jeon MJ, Chung SM, Jung HJ. Risk factors for the recurrence of pelvic organ prolapse.Gynecol Obstet Invest. 2008;6(4):268–73.
Abbas SM. Long–term results of the anterior Delorme's operation in the management of symptomatic rectocele. Dis Colon Rectum. 2005;48:317–22.
Medina CA, Candiotti K, Takacs P. Wide genital hiatus is a risk factor for recurrence following anterior va¬ginal repair. Int J Gynaecol Obstet. 2008;101(2):184–187.
Crafoord K, Sydsjo A, Nilsson K, Kjolhede P. Pri¬mary surgery of genital prolapse: a shift in treatment tra¬dition. Acta Obstet Gynecol Scand. 2006;85(9):1104–08.
Whiteside JL, Weber AM, Meyn LA. Risk factors for prolapse recurrence after vaginal repair. Am J Obstet Gynecol. 2004;191:1533–38.
Shan-Rong Shi, Cheng Liu, Clive R. Taylor Standardization of Immunohistochemistry for Formalin-fixed, Paraffin-embedded Tissue Sections Based on the Antigen-retrieval Technique: From Experiments to Hypothesis. Journal of Histochemistry & Cytochemistry. 2007;55(2):105–9.
Digesu GA. The relationship of vaginal prolapse severity to symptoms and quality of life. BJOG. 2005;112:971–76.
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