The effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms – the causative agents of pustular skin infections in the treatment of acne vulgaris (acne vulgaris)

Authors

DOI:

https://doi.org/10.26641/2307-0404.2023.2.283344

Keywords:

acne vulgaris, skin microbiome, purified bacterial lysates, Acnevac

Abstract

The objective of the work was to study the effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, by comparing clinical data and the skin microbiome in patients with acne. The results of the study are based on the data of a comprehensive examination of 35 patients with acne of 2-3 degrees before and after treatment, as well as data of the examination of 15 patients of the control group. Examination methods: clinical examination of the skin, determination of the quantitative composition and microbiological identification of the skin microbiome (bacteria of the genera Staphylococcus, Streptococcus, Propionibacterium Corynebacterium, Micrococcus, Sarcina, Aerococcus, Acinetobacter, Brevibacterium, Citrobacter, Serratia, Lactobacillus; yeast-like fungi of the genera Malassesia and Candida, mold fungi ). In the studied patients with acne, the representative microorganisms of the skin microbiome were Propionibacterium acnes, S. epidermidis, and C. lipophilicum. In patients with acne, the stability of the skin microbiome was carried out due to the redistribution between S. epidermidis and C. lipophilicum. In patients receiving "Acnevac"® (Bioveta, a. s.), a component of a complex treatment, along with earlier periods of clinical improvement, there was noted an earlier normalization of the skin microbiome in comparison with patients receiving standard therapy. Approaches to the treatment of acne with antibiotics and chemotherapy require a revision. The state of the skin microbiome broadens knowledge on the pathogenesis of acne and the search for other means for the individual treatment of patients. Positive changes in the skin microbiome under the influence of treatment with purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, make it possible to recommend its use for a longer term – up to 6 months.

References

Bienova M, Kucherovi R. [Evaluation of the effectiveness of vaccine therapy ("Acnevac®") in the treatment of acne papulopustulosa]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii. 2019;1(72):75-8. Ukrainian.

Diudiun AD, Polion NN, Reznichenko NYu, Svirid SG, Gorbuntsov VV. ["AEvit" in the complex treat-ment of patients with acne]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii. 2018;2:48-55. Ukrainian. doi: https://doi.org/10.30978/UJDVK2018-2-48

Kutasevich YaF, Joraeva SL, Mangusheva VYu. [Study of the composition of the skin microbiota, analysis of its antibiotic resistance in patients with allergic dermatoses]. Eksperimental'naya i klinicheskaya meditsina. 2018;1(78):101-7. Ukrainian.

[About the consolidation of approximate provisions in the bacteriological services of the system of the Ministry of Health of Ukraine. Order of the Ministry of Health of Ukraine No. 500 dated 28 Dec 2002]. [Internet]. 2002 [cited 2022 Oct 12]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0500282-02#Text

[Protocol on the provision of medical assistance we are sick in the vulgar. Order of the Ministry of Health of Ukraine No. 312 on 05 Aug 2009. About the hardened clinical protocols for medical aid, we are ill at dermatovenerological ailments]. [Internet]. 2009 [cited 2022 Oct 12]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0312282-09#Text9

Acne vulgaris: management. NICE guideline. NICE Publ.; 2021. 53 p. Available from: https//nice.org.uk/guidance/ng198

Antwi-Boasiako C. Statistics and Research Methods for Medical Scientists. Mabel Ntiamoah; 2020. 246 р.

Dreno B, Araviiskaia E, Berardesca E, et al. Microbiome in healthy skin, update for dermatologists. J Eur Acad Dermatol Venereol. 2016;30(12):2038-47. doi: https://doi.org/10.1111/jdv.13965

Dréno B, Dagnelie MA, Khammari A, Corvec S. The Skin Microbiome: A New Actor in Inflammatory Acne. Am J Clin Dermatol. 2020;Sep 21(Suppl 1):18-24. doi: https://doi.org/10.1007/s40257-020-00531-1

Karadag AS, Aslan KM, Wu CY, Chen W, Parish LC. Antibiotic resistance in acne: changes, con-sequences and concerns. J Eur Acad Dermatol Venereol. 2021;35(1):73-8. doi: https://doi.org/10.1111/jdv.16686

Parvin Z, Kowsar M, Jafar A, Jafar S, Ali A. A Therapeutic Oral Vaccine Candidate against Propioni-bacterium acnes: Preparation and Immunological Eva-luation of Nanoparticles Encapsulated Sialidase-CAMP Fusion Protein. Brazilian Archives of Biology and Technology. 2020;63(1):e20190427. doi: https://dx.doi.org/10.1590/1678-4324-202019042

Ramasamy S, Barnard E, Dawson TL, Li H. The role of the skin microbiota in acne pathophysiology. Br J Dermatol. 2019;181(4):691-9. doi: https://doi.org/10.1111/bjd.18230

Segall Richard S, Niu Gao. Open Source Software for Statistical Analysis of Big Data: Emerging Research and Opportunities. Engineering Science Reference. 2020. 256 p.

Xu S, Zhu Y, Hu H, Liu X, Li L, Yang B, et al. The analysis of acne increasing suicide risk. Medicine (Baltimore). 2021;100(24):e26035. doi: https://doi.org/10.1097/MD.0000000000026035

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-73.e33. doi: https://doi.org/10.1016/j.jaad.2015.12.037

Published

2023-06-30

How to Cite

1.
Zakharov S, Zakharov V, Gorbuntsov V. The effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms – the causative agents of pustular skin infections in the treatment of acne vulgaris (acne vulgaris). Med. perspekt. [Internet]. 2023Jun.30 [cited 2024Jul.12];28(2):93-8. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/283344

Issue

Section

CLINICAL MEDICINE