Increasing the efficiency of osseointegration in dental implantation in patients with diabetic osteopathy by remodeling bone tissue and intensifying its density.




periodontitis, periodontal pathology, rapidly progressive generalized periodontitis, diabetes, markers of bone metabolism, dental implantation, recombinant morphogenetic protein BMP-2, ossein-hydroxyapatite complex


The purpose of the study was to increase the effectiveness of osseointegration of implants in dental implantation in patients with rapidly progressing generalized periodontitis combined with diabetic osteopathy by restoring normal remodeling of bone tissue and intensifying its density. The study included 84 patients aged 30 to 50 years (average 41.9±2.36 years) with type 2 diabetes mellitus associated with generalized periodontitis, among them 56 women and 28 men and 19 volunteer donors without periodontal and detected somatic pathology, identical by gender and age. Surgical intervention for the installation of dental implants was performed in 3 groups of patients identical by gender and age: I, II and III groups. Groups I and II included 52 patients (26 patients in each) with rapidly progressing generalized periodontitis, with type 2 diabetes, complicated by systemic osteoporosis, who differed only in the prescribed treatment complex. Group III was formed by patients with a similar pathology of periodontal tissues, but without background diabetic osteopathy (32 patients), who received an identical treatment complex with patients in Group II. During the surgical intervention, 282 dental implants were installed: 92 implants in group I patients, 89 implants in group II, and 101 dental implants in group III. At the same time, we strove to ensure that the percentage of the performed operations was approximately the same. The analysis of the obtained data of laboratory studies showed that in patients with diabetic osteopathy with rapidly progressing periodontitis and rapidly progressing generalized periodontitis without background pathology, a deeper imbalance of the processes of bone remodeling with high level of both – bone resorption and osteogenesis is observed, which causes acceleration of the destruction of periodontal bone tissue and their loss. At the same time, it was found that with a complex and correct selection of antiresorptive therapy, the level of markers of bone metabolism approaches the norm, which is positively reflected in the dynamics and frequency of osseointegration of dental implants. Our research and received data from laboratory studies showed that in patients with rapidly progressing generalized periodontitis with and without diabetic osteopathy, there is an inhomogeneity and imbalance in the functioning of bone remodeling, which negatively affects the process of osseointegration of dental implants and requires a complex approach in the selection of antiresorptive therapy. Inclusion in the protocol of dental implantation of recombinant morphogenetic protein in patients with diabetes with osteopathology leads to completion of osseointegration of dental implants in the term up to 3 months, and monotherapy with  ossein-hydroxyapatite complex in patients with rapidly progressing generalized periodontitis has a similar effect on the osseointegration process – it accelerates the recovery of bone tissue around dental implants.


Gudaryan OO, Kucherenko TO. [The state of bone metabolism in patients with various variants of the course of generalized periodontitis]. Visnyk problem biolohii i medytsyny. 2020;3:314-8. Ukrainian.

Gudaryan OO, Mashchenko IS, Kucherenko TO. [Treatment of aggressive (rapidly progressing) generalized periodontitis with the use of systemic enzyme therapy in combination with osteoinductive means]. Medicni perspektivi. 2020;25(3):144-52. Ukrainian. doi:

Alghamdi HS, Jansen JA. The development and future of dental implants. Dent Mater J. 2020;39(2):167-72. doi:

Prots H, Rozhko M, Pjuryk V, Nychyporchuk H, Pavelko N. Efficiency of dental implantation in prosthetic rehabilitation of patients with generalized periodontitis. Georgian Med News. 2021 May;(314):77-82. PMID: 34248031.

Do TA, Le HS, Shen YW, Huang HL, Fuh LJ. Risk Factors related to Late Failure of Dental Implant-A Systematic Review of Recent Studies. Int J Environ Res Public Health. 2020 Jun 2;17(11):3931. doi:

Camps-Font O, Martín-Fatás P, Clé-Ovejero A, Figueiredo R, Gay-Escoda C, Valmaseda-Castellón E. Post¬operative infections after dental implant placement: Variables associated with increased risk of failure. J Periodontol. 2018 Oct;89(10):1165-73. doi:

Liaw K, Delfini RH, Abrahams JJ. Dental Implant Complications. Semin Ultrasound CT MR. 2015 Oct;36(5):427-33. doi:

Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D. The Effects of Systemic Diseases and Medications on Implant Osseointegration: A Systematic Review. Int J Oral Maxillofac Implants. 2019 Suppl;34:s35-s49. doi:

Mashchenko IS, Kucherenko TO. [Clinical, immunological and metabolic features of acute and rapidly progressing variants of generalized periodontitis]. Suchasna stomatolohiia. 2020;4:26-32. Ukrainian. doi:

Germanchuk SM. [Morphobiochemical changes in periodontal tissues in experimental diabetes]. Ukrainskyi zhurnal medytsyny, biolohii ta sportu. 2018;3(4):13-9. Ukrainian. doi:

Jiang X, Zhu Y, Liu Z, Tian Z, Zhu S. Association between diabetes and dental implant complications: a systematic review and meta-analysis. Acta Odontol Scand. 2021 Jan;79(1):9-18. doi:

Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Periodontitis, implant loss and peri-implantitis. A meta-analysis. Clin Oral Implants Res. 2015 Apr;26(4):e8-e16. doi:

Monje A, Alcoforado G, Padial-Molina M, Suarez F, Lin GH, Wang HL. Generalized aggressive perio-dontitis as a risk factor for dental implant failure: a systematic review and meta-analysis. J Periodontol. 2014 Oct;85(10):1398-407. doi:

Patel RM. Dental Implants for Patients with Periodontitis. Prim Dent J. 2020 Jan 29;8(4):54-61. doi:

LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, Siris ES. The clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis International [Internet]. 2022Apr.28;33(10):2049-102. Available from:

Chiodini I, Bolland MJ. Calcium supplementation in osteoporosis: useful or harmful? Eur J Endocrinol. 2018 Apr;178(4):D13-D25. doi:

Mohsin S, Baniyas MM, AlDarmaki RS, Tekes K, Kalász H, Adeghate EA. An update on therapies for the treatment of diabetes-induced osteoporosis. Expert Opin Biol Ther. 2019 Sep;19(9):937-48. doi:

Castelo-Branco C, Dávila Guardia J. Use of os-sein-hydroxyapatite complex in the prevention of bone loss: a review. Climacteric. 2015 Feb;18(1):29-37. doi:

Johnson TB, Siderits B, Nye S, Jeong YH, Han SH, Rhyu IC, et al. Effect of guided bone regeneration on bone quality surrounding dental implants. J Biomech. 2018 Oct 26;80:166-70. doi:

James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, et al. A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng Part B Rev. 2016 Aug;22(4):284-97. doi:

Mitra S. Multiple Data Analyses and Statistical Approaches for Analyzing Data from Metagenomic Stu-dies and Clinical Trials. Methods Mol Biol. 2019;1910:605-34. doi:




How to Cite

Gudarian O, Cherednyk D. Increasing the efficiency of osseointegration in dental implantation in patients with diabetic osteopathy by remodeling bone tissue and intensifying its density. Med. perspekt. [Internet]. 2023Jun.30 [cited 2023Dec.2];28(2):136-42. Available from: