Oral lichen planus post COVID-19 vaccination: report of two cases





COVID-19, oral lichen planus, SARS-CoV-2 vaccine, case report


Manifestations of сoronavirus disease 2019, caused by SARS-CoV-2 virus, are diverse and can vary from asymptomatic infection to respiratory failure needing intensive care. Vaccines against SARS‐CoV‐2 focusing on the spike glycoprotein have shown promise in diminishing the spread of Covid‐19. Adverse effects, however, are associated with every vaccination. Currently, there are literature reports of some cases of lichen planus eruption following COVID-19 vaccine injection. Oral lichen planus is a relatively common immune-mediated dermatologic disorder that can occur isolated or associated with cutaneous lichen planus. Postvaccination lichen planus has previously been reported in the literature as a rare adverse event following various vaccinations, especially hepatitis A and B, influenza, and varicella. The majority of patients presented with classic cutaneous lichen planus, although some reports highlighted primarily mucosal involvement. Herein we describe two rare cases of erosive-ulcerous oral lichen planus among SARS-CoV-2 vaccine recipients. The first is a case of a 67-year-old male who developed mucocutaneous lichen planus 5 days after administration of the single-dose of Ad26.COV2.S COVID-19 vaccine. In the second case, a 56-year-old female presented with reactivation of oral lichen planus after receiving a first dose of Pfizer COVID-19 vaccination 2 days earlier. The mechanism of the association between vaccines and lichen planus is not known, it is attributed to cell-mediated autoimmunity. Although there is currently no evidence of a causal relationship between SARS-CoV-2 vaccination and lichen planus, these clinical observations suggest that the COVID-19 vaccine is a possible key initiating event leading to the development or recurrence of this disease.


Virah MV, Rogach IM, Palko AI, Slyvka YI. [Analysis of current data on vaccination against COVID-19 and prospects for vaccination of the population of Ukraine]. Ukraina. Zdorovia natsii. 2021;1(63):56-62. Ukrainian. doi: https://doi.org/10.24144/2077-6594.1.1.2021.227155

Chernyshova LI, Chernyshov AV. [ Comparative characteristics of vaccines against COVID-19]. Aktualna infektolohiia. 2021;9(2):5-9. Ukrainian. doi: https://doi.org/10.22141/2312-413Х.9.2.2021.236218

Mavrutenkov VV, Revenko HO. [Vaccine prophylaxis: achievements, problems, perspectives of deve-lopment]. Medicni perspektivi. 2016;3:56-60. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2016.3.82025

Sinha A, Kumar R, Singh AR. Implication of mass COVID-19 vaccination on dermatology practice in 2021. Dermatol Ther. 2021 Mar;34(2):e14765. doi: https://doi.org/10.1111/dth.14765

Bozhik SO. [Clinical characteristics of the dental status of patients with oral lichen planus]. Medytsyna sohodni i zavtra. 2021;90(3):82-90. Ukrainian. doi: https://doi.org/10.35339/msz.2021.90.3.boz

Hasiuk NV, Cherniak VV, Klitynska OV, et al. [Internet]. Additional methods of examination in dentistry. Ternopil: Palianytsia; 2017. Available from: http://repository.pdmu.edu.ua/bitstream/123456789/8780/1/Additional_methods.pdf

Rotaru DI, Sofineti D, Bolboacă SD, Bulboacă AE. Diagnostic Criteria of Oral Lichen Planus: A Narrative Review. Acta Clin Croat. 2020 Sep;59(3):513-22. doi: https://doi.org/10.20471/acc.2020.59.03.16

Svyatenko ТV, Litus АI, Kаdenko ОА, Svistunov IV. Manifestative Papular Dermatoses: Lichen Ruber Planus of the Mucous Membrane of Oral Cavity. J Clin Investigat Dermatol. 2016;4(2):4. doi: https://doi.org/10.13188/2373-1044.1000026

Shavit E, Hagen K, Shear N. Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know. F1000Res. 2020 Mar 24;9:F1000. doi: https://doi.org/10.12688/f1000research.18713.1

Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT. Oral Lichen Planus – Known and Unknown: a Review. Folia Med. 2018 Dec 1;60(4):528-35. doi: https://doi.org/10.2478/folmed-2018-0017

Nosratzehi T. Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments. Asian Pac J Cancer Prev. 2018 May 26;19(5):1161-7. doi: https://doi.org/10.22034/APJCP.2018.19.5.1161

Lai YC, Yew YW. Lichen planus and lichenoid drug eruption after vaccination. Cutis. 2017 Dec;100(6):E6-E20. PMID: 29360907.

Troeltzsch M, Gogl M, Berndt R, Troeltzsch M. Oral lichen planus following the administration of vector-based COVID-19 vaccine (Ad26.COV2.S). Oral Dis. 2021 Sep 30:14025. doi: https://doi.org/10.1111/odi.14025

Picone V, Fabbrocini G, Martora L, Martora F. A Case of New-Onset Lichen Planus after COVID-19 Vac-cination. Dermatol Ther (Heidelb). 2022 Feb 15;12(3):801-5. doi: https://doi.org/10.1007/s13555-022-00689-y

Babazadeh A, Miladi R, Barary M, et al. COVID-19 vaccine-related new-onset lichen planus. Clin Case Rep. 2022 Feb 2;10(2):e05323. doi: https://doi.org/10.1002/ccr3.5323

Alrawashdeh HM, Al-Habahbeh O, Naser AY, et al. Lichen Planus Eruption Following Oxford-AstraZeneca COVID-19 Vaccine Administration: A Case Report and Review of Literature. Cureus. 2022 Feb 27;14(2):e22669. doi: https://doi.org/10.7759/cureus.22669

Hertel M, Schmidt-Westhausen AM, Wendy S, et al. Onset of Oral Lichenoid Lesions and Oral Lichen Planus Following COVID-19 Vaccination: A Retro-spective Analysis of about 300,000 Vaccinated Patients. Vaccines (Basel). 2022 Mar 20;10(3):480. doi: https://doi.org/10.3390/vaccines10030480

Kaomongkolgit R, Sawangarun W. Oral lichen planus following mRNA COVID-19 vaccination. Oral Dis. 2022 Nov:10.1111/odi.14182. doi: https://doi.org/10.1111/odi.14182

McMahon DE, Kovarik CL, Damsky W, et al. Clinical and pathologic correlation of cutaneous COVID-19 vaccine reactions including V-REPP: a registry-based study. J Am Acad Dermatol. 2022 Jan;86(1):113-21. doi: https://doi.org/10.1016/j.jaad.2021.09.002




How to Cite

Samoilenko A, Oryshchenko V, Strelchenia T. Oral lichen planus post COVID-19 vaccination: report of two cases. Med. perspekt. [Internet]. 2023Sep.29 [cited 2024Mar.3];28(3):234-40. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/289265