Lymphoadenopathies caused by Bartonella henselae
DOI:
https://doi.org/10.26641/2307-0404.2023.4.294276Keywords:
Bartonella henselae, cat scratch disease, lymphadenitis, complication, atypical manifestations, treatmentAbstract
Bartonella henselae is the causative agent of cat scratch disease, the main manifestation of which is lymphadenopathy, but it can manifest as bacillary angiomatosis, injury to internal organs, joints, eyes, heart, kidneys. This disease is often encountered in the practical work of doctors, especially with an atypical form of the course, which occurs in 20% of adult patients. Often the disease is undiagnosed, mimicking lymphadenopathies caused by tumors of soft tissues and bones or other bacterial pathogens. The purpose of the work was to analyze clinical cases of cat scratch disease by the results of inpatient records data based on the leading clinical symptom – lymphadenitis, to summarize literature data related to morbidity, features of the clinical course and treatment of this disease. The description of two clinical cases of cat scratch disease in adult women aged 19 and 59 is given. The typical course of the disease in one of them at the beginning of the disease, was manifested by symptoms of general intoxication, fever, an increase of lymph nodes in the neck and axillary area, which coincided in time with the previously diagnosed bacterial angina. The diagnostic search ended with the set diagnosis and surgical operation three months after the onset of clinical manifestations of the disease. In the second case, a subfebrile body temperature, a painful lymph node in the right axillary area for 3 weeks were the reason to perform an invasive surgery twice for diagnosed bacterial process of unknown etiology. The reasons for late diagnosis and treatment of cat scratch disease in our patients were insufficient collection of epidemiological anamnesis, lack of vigilance of doctors, first of all, surgeons, regarding the clinical manifestations of the disease and late examination to find out the etiological factor of the disease. An elevated titer of IgM antibodies to Bartonella henselae 1:160 and 1:140 in two cases was the basis for confirming cat scratch disease. Based on the results of the literature analysis, an overview of typical and atypical manifestations of cat scratch disease, its diagnosis and treatment is presented. Bartonella henselae infection should be considered in all cases of lymphadenitis of unknown etiology, accompanied by high temperature, intoxication syndrome and a long course. In order to prevent the development of purulent complications and to avoid unreasonable invasive procedures, it is important to make a timely diagnosis and carry out appropriate antibacterial treatment at the initial stage of the manifestation of clinical symptoms of cat scratch disease.
References
Cheslock MA, Monica EE. Human Bartonellosis: an underappreciated public health problem? Trop Med Infect Dis. 2019 Apr 19;4(2):69. doi: https://doi.org/10.3390/tropicalmed4020069
Carvajal JA, Yamasque AA, Piccolomini JP. [He-pato-splenic involvement, an unusual finding secondary to cat-scratch disease: a clinical case]. Arch Argent Pediatr. 2021 Oct;119(5):e540-e544. Spanish. doi: https://doi.org/10.5546/aap.2021.e540
Rodríguez Alonso B, Alonso-Sardón M, Rodri-gues Almeida HM, Romero-Alegria Á, Pardo-Lledias J, Velasco-Tirado V, et al. Epidemiological of cat scratch disease among inpatients in the Spanish health system (1997-2015). Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):849-57. doi: https://doi.org/10.1007/s10096-020-04087-0
Tsuneoka H, Otsuyama KI, Motoki Y, Nojima J, Nishikawa J, Ichihara K. Exploring the seasonal and regional features of cat-scratch disease on the basis of anti-Bartonella henselae IgM/IgG positive rates in Japan. J Infect Chemother. 2022 Jan;28(1):112-5. doi: https://doi.org/10.1016/j.jiac.2021.09.003
Mennini M, Valentini D, Di Camillo C, Vit-tucci AC, Grandin A, Lancella L, et al. Bartonella henselae in Italy: a rare seasonal infection. Minerva Pediatr. 2019 Oct;71(5):415-9. doi: https://doi.org/10.23736/S0026-4946.16.04414-5
Theel ES, Ross T. Seasonality of Bartonella hen-selae IgM and IgG antibody positivity rates. J Clin Micro-biol. 2019 Nov 22;57(12):e01263-19. doi: https://doi.org/10.1128/JCM.01263-19
Nelson CA, Saha S, Mead PS. Cat scratch disease in the United States, 2005–2013. Emerg Infect Dis. 2016;22(10):1741-6. doi: https://doi.org/10.3201/eid2210.160115
Baranowski K, Huang B. Cat Scratch Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Apr 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482139/
Resto-Ruiz S, Burgess A, Anderson BE. The role of the host immune response in pathogenesis of Bartonella henselae. DNA Cell Biol. 2003;22(6):431-40. doi: https://doi.org/10.1089/104454903767650694
Maini R, Nagalli S. Lymphadenopathy. In: Stat-Pearls [Internet]. Treasure Island (FL): StatPearls Pub-lishing; 2023 [cited 2023 Apr 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558918/
Hozáková L, Rožnovský L, Fakhouri F, Doležíl-ková J, Janout V. Lymph node syndrome associated with cat scratch disease in children and adults. Cas Lek Cesk. 2018;157(3):146-51. PMID: 30441948.
Maly VP, Asoyan I. [Generalized form of the cat scratch disease on the background of immunodefficiency with liver injury]. Infektsiyni Khvoroby. 2022;4:68-73. Ukrainian.
doi: https://doi.org/10.11603/1681-2727.2021.4.12842
Huarcaya E, Maguina C, Merello J, Cok J, Birt-les R, Infante B, et al. A prospective study of cat scratch disease in Lima-Peru. Rev Inst Med Trop Sao Paulo. 2002 Nov-Dec;44(6):325-30. doi: https://doi.org/10.1590/S0036-46652002000600006
Montone KT. Infectious disease of the head and neck. Am J Clin Pathol. 2007;128(1):35-67. doi: https://doi.org/10.1309/6BBT12WGNK77N4EH
Maria HKS, Gazzoli E, Drummond MR, Al¬mei-da AR, Santos LSD, Pereira RM, et al. Two-year history of lymphadenopathy and fever caused by Bartonella henselae in a child. Rev Inst Med Trop Sao Paulo. 2022 Feb 16;64:e15. doi: https://doi.org/10.1590/S1678-9946202264015
Lins KA, Drummond MR, Ferreira PEN. Cuta-neous manifestations of bartonellosis. An Bras Dermatol. 2019 Sep-Oct;94(5):594-602. doi: https://doi.org/10.1016/j.abd.2019.09.024
Uluğ M. Evaluation of cat scratch disease cases reported from Turkey between 1996 and 2013 and review of the literature. Cent Eur J Public Health. 2015;23(2):170-5. doi: https://doi.org/10.21101/cejph.a4040
Donà D, Fovino LN, Mozzo E, Cabrelle G, Bor-din G, Lndin R, et al. Osteomyelitis in cat-scratch disease: a never-ending dilemma – a case report and literature review. Case Rep Pediatr. 2018;2018:1679306. doi: https://doi.org/10.1155/2018/1679306
Zhu M, Zhang S, Shi Q, Sun X, Zhang X, Wang H, et al. Swollen inguinal lymph nodes with low fever and night sweat: diagnosis and treatment of case of cat-scratch disease lymphadenitis with sinus formation. Heliyon. 2022;8(9):e10448. doi: https://doi.org/10.1016/j.heliyon.2022.e10448
Lemos AP, Domingues R, Gouveia C, de Sousa R, Brito MJ. Atypical bartonellosis in children: What do we know? J Paediatr Child Health. 2021 May;57(5):653-8. doi: https://doi.org/10.1111/jpc.15304
Nawrocki CC, Max RJ, Marzec NS, Nelson CA. Atypical manifestations of cat-scratch disease, United States, 2005-2014. Emerg Infect Dis. 2020 Jul 01;26(7):1438-46. doi: https://doi.org/10.3201/eid2607.200034
Salicio-Bermejo Y, Cilla-Eguiluz G, Blanco-Este-ban A, Martin-Peñaranda T, Grandioso-Vas D, Eche-verría-Irigoyen MJ. Neuroretinitis caused by Bartonella henselae in Gipuzkoa, 2014-2019. Enferm Infecc Micro-biol Clin (Engl Ed). 2021 Nov;39(9):451-3. doi: https://doi.org/10.1016/j.eimce.2021.08.001
Jurja S, Stroe AZ, Pundiche MB, Axelerad SD, Mateescu G, Micu AO, et al. The clinical profile of cat-scratch disease’s neuro-ophthalmological effects. Brain Sci. 2022;12(2):217. doi: https://doi.org/10.3390/brainsci12020217
Nakamura M, Ura S, Yabe I, Otsuki M, Soma H, Ogata A. Cat scratch disease-associated encephalitis fol-lowed by parkinsonism. Intern Med. 2022;61:3115-20. doi: https://doi.org/10.2169/internalmedicine.9047-21
Canneti B, Cabo-López I, Puy-Núñez A, García García JC, Cores FJ, Trigo M, et al. Neurological presen-tations of Bartonella henselae infection. Neurol Sci. 2019 Feb;40(2):261-8. doi: https://doi.org/10.1007/s10072-018-3618-5
Fang Q, Wang P, Qin S, Liu S, He J. Case report: Intracranial lesions of cat-scratch disease mimicking an atypical meningioma. Front Neurol. 2023 Feb 8;14:1080331. doi: https://doi.org/10.3389/fneur.2023.1080331
Agrawal SK, Das P, Shalimar, Swatantra G, Chaudhry R. Multifocal hepatic abscesses in immuno-competent patient due to Bartonella henselae: case report with review of literature. Indian J Med Microbiol. 2019;37(2):292-95. doi: https://doi.org/10.4103/ijmm.IJMM_19_4
Sharma R, Arshad A, Sardar S, Zafar A. Hepato-splenic Bartonellosis in an Immunocompetent Teenager: An Atypical Presentation of Cat-Scratch Disease. Cureus. 2021;13(2):e13219. doi: https://doi.org/10.7759/cureus.13219
Filipponi V, Trasarti S, Maccioni F, Zippi M, Bu-sato L, Arienzo F, et al. Abdominal Lymphadenopathy: Hypothesize Cat-Scratch Disease and Avoid Abdominal Excisional Biopsy. Hemato. 2022;3(4):771-8. doi: https://doi.org/10.3390/hemato3040052
Yehudina Y, Trypilka S. Case reports of cat scratch disease in patient with unjustified surgical intervention. Cureus. 2021;13(4):e14632. doi: https://doi.org/10.7759/cureus.14632
Dželalija B, Petrovec M, Avšič-Županc T. Pro-bable atypical cat scratch disease presenting as isolated posterior pancreatic duodenal lymphadenitis and abdo-mi¬nal pain. Clin Infect Dis. 2001;33(6):912-4. doi: https://doi.org/10.1086/322692
Kozak IO, Sukhodolia SA, Kozak LI, Ladysh-kin VV. [Spontaneous splenic rupture]. Reports of Vin-nytsia National Medical University. 2020;24(2):250-2. Ukrainian. doi: https://doi.org/10.31393/reports-vnmedical-2020-24(2)-09
Tay S, Freeman K, Baird R. Сlinical mani-festations associated with Bartonella henselae infection in a tropical region. Am J Trop Med Hyg. 2021;104(1):198-206. doi: https://doi.org/10.4269/ajtmh.20-0088
King KY, Hicks MJ, Eldin KW, Starke JR, Mi-chael M. Persistent cat scratch disease requiring surgical exci¬sion in a patient with MPGN. Pediatrics. 2015;135(6):1514-7. doi: https://doi.org/10.1542/peds.2014-2923
Erdem G, Watson JR, Hunt WG, Young C, Sou-verbielle CT, Honegger JR, et al. Clinical and radiologic manifestations of bone infection in children with cat-scratch disease. J Pediatr. 2018;201:274-80. doi: https://doi.org/10.1016/j.jpeds.2018.05.033
Kort JG, Robben SG, Schrander JJ, Rhijn LW. Multifocal osteomyelitis in a child: a rare manifestation of cat scratch disease: a case report and systematic review of the literature. J Pediatr Orthop B. 2006;15(4):285-8. doi: https://doi.org/10.1097/01202412-200607000-00010
Razafindrazaka H, Redl S, Aouchiche F, Grosle-ron S, Nazal-Traissac EM, Rispal P, et al. Bone invol-vement in cat scratch disease. Rev Med Interne. 2021 Dec;42(12):875-80. doi: https://doi.org/10.1016/j.revmed.2021.06.010
Allizond V, Costa C, Sidoti F, Scutera S, Bian-co G, Sparti R, et al. Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study. PloS ONE. 2019;14(2):e0211945. doi: https://doi.org/10.1371/journal.pone.0211945
Jost M, Latz A, Ballhorn W, Kempf VAJ. Deve-lopment of a specific and sensitive enzyme-linked im-munosorbent assay as an in vitro diagnostic tool for detection of bartonella henselae antibodies in human serum. J Clin Microbiol. 2018;56:e01329. doi: https://doi.org/10.1128/JCM.01329-18
Landes M, Maor Y, Mercer D, Habot-Wilner Z, Bilavsky E, Chazan B, et al. Cat Scratch Disease Pre-senting as Fever of Unknown Origin Is a Unique Clinical Syndrome. Clin Infect Dis. 2020 Dec 31;71(11):2818-24. doi: https://doi.org/10.1093/cid/ciz1137
Dhal U, Hicklen RS, Tarrand J, Kontoyiannis DP. Cat Scratch Disease as a Mimicker of Malignancy. Open Forum Infect Dis. 2021 Oct 5;8(11):ofab500. doi: https://doi.org/10.1093/ofid/ofab500
Bernard SA, Walker EA, Carroll JF, Klassen-Fischer M, Murphey MD. Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. Skeletal Radiol. 2016;45(9):1227-34.
doi: https://doi.org/10.1007/s00256-016-2407-6
Chen Y, Fu YB, Xu XF, Pan Y, Lu CY, Zhu XL, et al. Lymphadenitis associated with cat-scratch disease simu¬lating a neoplasm: imaging findings with histopathological associations. Oncol Lett. 2018 Jan;15(1):195-204. doi: https://doi.org/10.3892/ol.2017.7311
Amerstorfer F, Igrec J, Valentin T, Leithner A, Leit¬ner L, Glehr M, et al. Cat at home? Cat scratch disease with atypical presentations and aggressive radiological findings mimicking sarcoma, a potential diagnostic pitfall. Acta Orthop. 2021;92(6):753-9. doi: https://doi.org/10.1080/17453674.2021.1941624
Goaz S, Rasis M, Ehrenreich IB, Shapira L, Ha-lutz O, Graidy-Varon M, et al. Molecular diagnosis of cat scratch disease: a 25-year retrospective comparative analysis of various clinical specimens and different PCR assays. ASM Journals Microbiology Spectrum. 2022;10(2). doi: https://journals.asm.org/doi/pdf/10.1128/spectrum.02596-21
Pecora F, Abate L, Scavone S, Petrucci I, Costa F, Caminiti C, et al. Management of Infectious Lymphadenitis in Children. Children (Basel). 2021;8(10):860. doi: https://doi.org/10.3390/children8100860
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