Dynamics of heart rhythm disorders in combatants with acute myocarditis during a 6-month follow-up

E.G. Nesukay; V.M. Kovalenko; S.V. Cherniuk; R.M. Kirichenko; A.I. Frolov; A.B.  Slyvna

doi:10.26641/2307-0404.2024.1.300500

Authors

E.G. Nesukay SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0000-0003-0904-7406
V.M. Kovalenko SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0000-0003-3802-9207
S.V. Cherniuk SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0000-0002-7151-5437
R.M. Kirichenko SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0000-0003-0564-8052
A.I. Frolov SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0009-0008-5071-8156
A.B. Slyvna SI "National Scientific Center "The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Sciences of Ukraine", Svyatoslava Khorobroho str., 5, Kyiv, 03151, Ukraine https://orcid.org/0009-0001-5598-9069

DOI:

https://doi.org/10.26641/2307-0404.2024.1.300500

Keywords:

acute myocarditis, heart rhythm disorders, combatants, 6-month follow-up

Abstract

The main factors of an unfavorable prognosis, are life-threatening heart rhythm disorders which determine the severity of the clinical course of myocarditis, in addition to impaired contractility and dilatation of the left ventricle (LV). The aim of the study was to assess the frequency and nature of arrhythmias and establish predictors of their long-term persistence, assess the severity of anxiety and depression, changes in heart rate variability in combatants on the background of changes in the structural and functional state of the left ventricle during a 6-month follow-up. The study included 52 male servicemen (combatants) with acute myocarditis (AM) with an average age of 33.4±2.5 years. All patients were assessed by Questionnaire according to the Hospital Anxiety and Depression Scale (HADS) and underwent 24 hour ECG monitoring, transthoracic echocardiography and cardiac magnetic resonance (CMR) with late enhancement using gadovist. At the onset of AM frequent supraventricular (30.7% of cases) and frequent ventricular (42.3% of cases) extrasystolic arrhythmia, as well as paroxysms of non-sustained ventricular tachycardia (26.9% of cases) on the background of heart rhythm variability disorders were recorded. After 6 months, there was an improvement in the structural and functional state of the heart, which was characterized by a decrease in dilatation and an improvement of LV systolic function, a decrease in the volume of the inflammatory lesion and the total number of affected LV segments revealed on cardiac MRI, which was associated with a decrease in the number of ventricular rhythm disorders and reduction of clinical manifestations of anxiety according to the HADS scale. The obtained data indicate that the persistence of supraventricular rhythm disorders is associated with the long-term presence of anxiety and low values of standard deviation of RR intervals (SDNN) and root mean square of successive differences between normal heartbeats (RMSSD). Also predictors of persistence of non-sustained ventricular tachycardia paroxysms were established – SDNN value ≤80.0 ms, LV end-diastolic volume index ≥95 ml/m², total number of affected LV segments ≥6 segments, presence of delayed contrasting in ≥3 LV segments, presence of ≥12 points on the HADS scale and predictors of atrial fibrillation – SDNN value ≤80.0 ms, RMSSD value ≤12.0 ms, total number of affected segments of LV≥6 seg. and ≥12 points on the HADS anxiety scale, determined at the onset of AM.

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