Side effects and hypersensitivity reactions to corticosteroids
DOI:
https://doi.org/10.26641/2307-0404.2024.2.307587Keywords:
side effects, taking drugs, safety, patch test, corticosteroids, hypersensitivityAbstract
The relevance of the topic under study is due to the fact that patients receiving large or repeated doses of corticosteroids often suffer from hypersensitivity reactions or side effects from taking this category of drugs. As a result, this poses a serious problem for healthcare authorities, as the scientific understanding of this phenomenon is still at an early stage. The purpose of study is to comprehensively disclose the various types of mechanisms underlying corticosteroid hypersensitivity, as well as to develop recommendations for more accurate methods of diagnosis, treatment, and prevention of this reaction. To achieve this goal, this theoretical study used various methods, including analysis, deduction, abstraction and generalization, and the method of synthesis. The results of the study underscore the broad spectrum of applications for corticosteroid drugs in medicine, highlighting their systemic effects and potential for side effects and hypersensitivity reactions across various bodily systems. These adverse reactions encompass hyperglycemia, hypertension, respiratory issues, visual impairments, skin conditions like contact dermatitis, bone tissue complications, and behavioral disorders, notably in children. Administering corticosteroids in COVID-19 treatment necessitates caution due to the potential for life-threatening immediate hypersensitivity reactions, which may be mistaken for disease progression. The results and conclusions of this study, which were formed using the above methods, may lead to a more accurate diagnosis of hypersensitivity to drugs such as corticosteroids, and may also contribute to the development of effective preventive measures. This study is of practical importance for dermatologists, allergists and immunologists, as well as researchers working in the field of rheumatology, allergology and immunology.
References
Gowin E, Toczyłowski K, Sulik A, Wysocki J, Januszkiewicz-Lewandowska D. The role of glucocorti-coids in the treatment of multisystem inflammatory syndrome (MIS-C)-data from POLISH MIS-C registry. Children. 2022;9(2):178. doi: https://doi.org/10.3390/children9020178
Marczak H, Peradzyńska J, Seidl E, Griese M, Urban¬kowski T, Lange J, et al. The improved clinical course of persistent tachypnea of infancy with inhaled bronchodilators and corticosteroids. Pediatr Pulmonol. 2021;56(12):3952-9. doi: https://doi.org/10.1002/ppul.25674
Skarzynska MB, Skarzynski PH. Corticosteroids in otorhinolaryngology. In: Corticosteroids – A Paradig-matic Drug Class. London: IntechOpen; 2021. doi: https://doi.org/10.5772/intechopen.98636
Damiański P, Kardas G, Panek M, Kuna P, Kup-czyk M. Improving the risk-to-benefit ratio of inhaled corticosteroids through delivery and dose: Current progress and future directions. Expert Opin Drug Saf. 2022;21(4):499-515. doi: https://doi.org/10.1080/14740338.2022.1999926
Podlecka-Piętowska A, Barć K, Denisiuk A, Nojszewska M, Zakrzewska-Pniewska B. COVID-19 in neuromyelitis optica spectrum disorder patients in Poland. Mult Scler Relat Disord. 2022;60:103698. doi: https://doi.org/10.1016/j.msard.2022.103698
Mahlab-Guri K, Asher I, Sthoeger Z. Immediate and delayed hypersensitivity reactions to corticosteroids – Prevalence, diagnosis and treatment. Swiss Med Wkly. 2023;153:40025. doi: https://doi.org/10.57187/smw.2023.40025
Hałubiec P, Jaworek AK, Wojas-Pelc A. Clinical aspects of the treatment of atopic dermatitis with topical glucocorticoids and calcineurin inhibitors – A pilot ques-tionnaire study. Folia Med Cracov. 2023;63(1):97-108. doi: http://dx.doi.org/10.24425/fmc.2023.145433
Godovantes OI, Kitsak TS, Vitkovsky OO, Kuz-niak LV, Godovantes OS, Chaikovska NM, et al. The influence of diffuse nontoxic goiter on the state of protective mechanisms of the oral cavity in children. J Med Life. 2020;13(1):21-5. doi: https://doi.org/10.25122/jml-2020-0013
Lisnyy I, Zakalska O, Dmytriiev D, Dmytriiev K, Dobrovanov O. Pre-emptive analgesia with nonsteroidal anti-inflammatory drugs randomized, double-blind placebo-controlled study. Lekarsky Obzor. 2021;70(5):195-202.
Stone S, Malanga GA, Capella T. Corticosteroids: Review of the history, the effectiveness, and adverse effects in the treatment of joint pain. Pain Physician. 2021;24(S1):233-46. doi: https://doi.org/10.36076/ppj.2021.24.S233-S246
Denefil OV, Charnosh SM. Development of oxidative stress in different experimental models of hypothyroidism in immature rats. Bull Med Bio Res. 2022;4(1):34-8. doi: https://doi.org/10.11603/bmbr.2706-6290.2022.1.12969
Van Noord B, Samaan C, Flamm A. A Case of delayed and immediate hypersensitivity reactions induced by corticosteroids. Dermatitis. 2024 Mar-Apr;35(2):191-2. doi: https://doi.org/10.1089/derm.2023.0146
Parisi GF, Leonardi S, Ciprandi G, Corsico A, Licari A, Miraglia Del Giudice M, et al. Cetirizine use in childhood: An update of a friendly 30-year drug. Clin Molec Allergy. 2020;18(1):2. doi: https://doi.org/10.1186/s12948-020-00118-5
Barbaud A, Waton J. Systemic allergy to cortico-steroids: Clinical features and cross reactivity. Curr Pharm Des. 2016;22(45):6825-31. doi: https://doi.org/10.2174/1381612822666161013092339
15.Kosmuratova R, Kudabayeva K, Grjibovski А, Kerimkulova A, Bazargaliyev Y. Association of leptin with anthropometric indexes, dyslipidemia and carbohydrate metabolism in Kazakh adults. Problems of Nutrition [Internet]. 2021Jan.1;90(6):85-91. Available from: https://www.voprosy-pitaniya.ru/ru/jarticles_diet/931.html?SSr=43013488d002ffffffff27c__07e6010c022b2a-4642
Torres MJ, Canto G. Hypersensitivity reactions to corticosteroids. Curr Opin Allergy Clin Immunol. 2010;10(4):273-9. doi: https://doi.org/10.1097/ACI.0b013e32833b1f34
17.Vatti RR, Ali F, Teuber S, Chang C, Gershwin ME. Hypersensitivity Reactions to Corticosteroids. Clinical Reviews in Allergy & Immunology [Internet]. 2013Apr.9;47(1):26-37. Available from: http://link.springer.com/10.1007/s12016-013-8365-z
Parisi GF, Indolfi C, Decimo F, Leonardi S, Mi-raglia del Giudice M. COVID-19 pneumonia in children: from etiology to management. Front Ped. 2020;8:616622. doi: https://doi.org/10.3389/fped.2020.616622
Patel A, Bahna SL. Immediate hypersensitivity reactions to corticosteroids. Ann Allergy Asthma Im-munol. 2015;115(3):178-82. doi: https://doi.org/10.1016/j.anai.2015.06.022
Parisi GF, Leonardi S, Ciprandi G, Corsico A, Licari A, Miraglia del Giudice M, et al. Antihistamines in children and adolescents: A practical update. Allergologia Immunopathologia. 2020;48(6):753-62. doi: https://doi.org/10.1016/j.aller.2020.02.005
Yang MK, Kim GJ, Choi YA, Sa HS. Efficacy and safety of intravenous glucocorticoid therapy for IgG4-related ophthalmic disease. PLoS ONE. 2023;18(4):e0284442. doi: https://doi.org/10.1371/journal.pone.0284442
Patel R, Naqvi SA, Griffiths C, et al. Systemic adverse effects from inhaled corticosteroid use in asthma: A systematic review. BMJ Open Respir Res. 2020;7(1):e000756. doi: https://doi.org/10.1136/bmjresp-2020-000756
Voltolini S, Fumagalli F. Delayed corticosteroid hypersensitivity: A clinical management proposal. Eur Ann Allergy Clin Immunol. 2021;53(4):171-6. doi: https://doi.org/10.23822/EurAnnACI.1764-1489.164
Otani IM, Banerji A. Immediate and delayed hypersensitivity reactions to corticosteroids: Evaluation and management. Curr Allergy Asthma Rep. 2016;16(3):18. doi: https://doi.org/10.1007/s11882-016-0596-7
Kawanami D, Takashi Y, Tanabe M. Significance of metformin use in diabetic kidney disease. Int J Mol Sci. 2020;21(12):4239. doi: https://doi.org/10.3390/ijms21124239
Bonner R, Albajrami O, Hudspeth J, Upadhyay A. Diabetic kidney disease. Prim Care. 2020;47(4):645-59. doi: https://doi.org/10.1016/j.pop.2020.08.004
Ramadan AA, Gaffin JM, Israel E, Phipatanakul W. Asthma and corticosteroid responses in childhood and adult asthma. Clin Chest Med. 2019;40(1):163-77. doi: https://doi.org/10.1016/j.ccm.2018.10.010
Feng J, Lu X, Li H, Wang S. The roles of hydrogen sulfide in renal physiology and disease states. Ren Fail. 2022;44(1):1289-08. doi: https://doi.org/10.1080/0886022X.2022.2107936
Zhang H, Zhao H, Guo N. Protective effect of hydrogen sulfide on the kidney (Review). Mol Med Rep. 2021;24(4):696. doi: https://doi.org/10.3892/mmr.2021.12335
Kulkarni S, Durham H, Glover L, Ather O, Phillips V, Nemes S, et al. Metabolic adverse events associated with systemic corticosteroid therapy – A systematic review and meta–analysis. BMJ Open. 2022;12(12):e061476. doi: https://doi.org/10.1136/bmjopen-2022-061476
Gaponenko YY, Korda MM. Potentiation of the herbicide glyphosate negative effect on the cytokine profile by zinc oxide nanoparticles. Bull Med Biol Res. 2023;5(1):5-9.
Biradar SM, Dhanavidya S, Kavya P, Keerthi T, Sunanda N, Marapur SC, et al. Bullous pemphigoid a rare autoimmune disease: a case report. Int J Med Medical Res. 2018;4(2):20-3. doi: https://doi.org/10.11603/ijmmr.2413-6077.2018.2.9248
Koshi EJ, Young K, Mostales JC, Vo KB, Burgess LP. Complications of corticosteroid therapy: A comprehensive literature review. J Pharm Technol. 2022;38(6):360-7. doi: https://doi.org/10.1177/87551225221116266
34.Lafaurie M, Martin-Blondel G, Delobel P, Kamar N, Charpentier S, Sommet A, Moulis G. Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19. BMC Pharmacology and Toxicology [Internet]. 2021Mar.11;22(1). Available from: https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-021-00480-3
35.Chang X, Li S, Fu Y, Dang H, Liu C. Safety and efficacy of corticosteroids in ARDS patients: a systematic review and meta-analysis of RCT data. Respiratory Research [Internet]. 2022Nov.4;23(1). Available from: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02186-4
Karn M, Yonghang S, Ghimire S. Corticosteroids in COVID-19: We should be mindful of their acute toxicities. J Clin Pharmacol. 2021;61(10):1301-2. doi: https://doi.org/10.1002/jcph.1936
Oliynyk O, Barg W, Oliynyk Y, Dubrov S, Gurianov V, Rorat M. Lack of difference in tocilizumab efficacy in the treatment of severe COVID-19 caused by different SARS-COV-2 variants. J Pers Med. 2022;12(7):1103. doi: https://doi.org/10.3390/jpm12071103
Wang K, Tan F, Zhou R, Liu D, Ni Z, Liu J, et al. Therapeutic response to corticosteroids in a critically ill patient with COVID-19: A case report. Medicine. 2020;99(31):e21597. doi: https://doi.org/10.1097/MD.0000000000021597
Yang X, Jin H. Safety of corticosteroids in the treatment of acute respiratory disease in children: A systematic review and meta-analysis. Transl Pediatr. 2022;11(2):194-203. doi: https://doi.org/10.21037/tp-21-577
Bodum KS, Hjerrild BE, Dalsgaard S, Ru-bak SLM. Behavioural side effects of inhaled cortico-steroids among children and adolescents with asthma. Respir Res. 2022;23(1):192. doi: https://doi.org/10.1186/s12931-022-02112-8
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Medicni perspektivi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
