The mechanism of physical exercises increases heat shock protein 70 (HSP70) (a systematic review)
DOI:
https://doi.org/10.26641/2307-0404.2024.4.319168Keywords:
HSP70, oxidative stress, physical exercise, inflammation, reactive oxygen species, catalase, superoxide dismutaseAbstract
This study aimed to analyze physical exercise in increasing the expression of heat shock protein 70 (HSP70). This research is a systematic review involving searches from journal databases such as Pubmed, Web of Science, and Science Direct. Before starting the search, the study determines inclusion and exclusion criteria. The inclusion criteria were articles that discussed oxidative stress, physical exercises, and heat shock protein 70 (HSP70), and were published over the last five years (2018-2023). Meanwhile, the articles were excluded if they were published in non-reputable journals or were not indexed by Scopus and Web of Science. A total of 3211 articles from the Science Direct, Pubmed, and Web of Science databases were initially identified. Among them, ten articles met the inclusion criteria and thus were selected and analyzed for this systematic review. For standard operations, this study follows the preferred reporting items for systematic reviews and meta-analyses (PRISMA) assessment. The results showed that physical exercises played a certain role in increasing HSP70 expression as a physiological reaction to exercises. The increase in HSP70 is good as it can reduce and prevent inflammation, which reduces cell damage due to physical stress. Additionally, HSP70 increases catalase and superoxide dismutase, the processes that can reduce reactive oxygen species (ROS) caused by physical exercises. This enzyme is also important in protein optimization based on requirements. Therefore, we recommend doing physical exercises to improve health and avoid degenerative diseases.
References
Marinho DA, Ferraz R, Toubekis AG, Neiva HP. Editorial: Musculoskeletal Adaptations to Training and Sports Performance: Connecting Theory and Practice. Front Physiol. 2022 Mar 3;13:866895. doi: https://doi.org/10.3389/fphys.2022.866895
Wibawa JC, Arifin MZ, Herawati L. Ascorbic Acid Drink after Submaximal Physical Activity can Maintain the Superoxide Dismutase Levels in East Java Student Regiment. Indian J Forensic Med Toxicol. 2021;15(3):3383-92. doi: https://doi.org/10.37506/ijfmt.v15i3.15824
Baghaiee B, Bayatmakoo R, Karimi P, Pescatello LS. Moderate Aerobic Training Inhibits Middle-Aged Induced Cardiac Calcineurin-NFAT Signaling by Impro-ving TGF-ß, NPR-A, SERCA2, and TRPC6 in Wistar Rats. Cell J. 2021;23(7):756-62. doi: https://doi.org/10.22074/cellj.2021.7531
El Assar M, Álvarez-Bustos A, Sosa P, Angulo J, Rodríguez-Mañas L. Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging. Int J Mol Sci. 2022;23(15):8713. doi: https://doi.org/10.3390/ijms23158713
Harahap NS, Amelia R, Sibuea A, Manalu N, Novita N. HSP70 (heat shock protein 70) expression and antioxidant as a protective againts oxidative stress triggered by sub-maximal physical activity. IOP Conf Ser Earth Environ Sci. 2021;713(1):012051. doi: https://doi.org/10.1088/1755-1315/713/1/012051
Pouzesh Jadidi, Seifi-Skishahr F, Bolboli L, Ghoroughchi AP. Effect of high intensity interval training on cardiomyocytes HSP70 and Caspase-3 gene expression le¬vels in myocardial infarction male rat model. Journal of Applied Health Studies in Sport Physiology. 2022;9(2):1-11. doi: https://doi.org/10.22049/JAHSSP.2021.27521.1407
Guerrero C, Collado-Boira E, Martinez-Navarro I, et al. Impact of plasma oxidative stress markers on post-race recovery in ultramarathon runners: A sex and age perspective overview. Antioxidants. 2021;10(3):1-12. doi: https://doi.org/10.3390/antiox10030355
Belenichev IF, Aliyeva OG, Popazova OO, Bukhtiyarova NV. Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators. Front Cell Neurosci. 2023;17:1131683. doi: https://doi.org/10.3389/fncel.2023.1131683
Zhang H, Gong W, Wu S, Perrett S. Hsp70 in Re-dox Homeostasis. Cells. 2022;11(5):1-18. doi: https://doi.org/10.3390/cells11050829
Rebeaud ME, Mallik S, Goloubinoff P, Tawfik DS. On the evolution of chaperones and cochaperones and the expansion of proteomes across the Tree of Life. Proc Natl Acad Sci USA. 2021;118(21):e2020885118. doi: https://doi.org/10.1073/pnas.2020885118
Du S, Liu Y, Yuan Y, et al. Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy. Front Cell Dev Biol. 2022;10:1-16. doi: https://doi.org/10.3389/fcell.2022.942828
Tang S, Geng Y, Lin Q. The role of mitophagy in metabolic diseases and its exercise intervention. Front Physiol. 2024;15:1-20. doi: https://doi.org/10.3389/fphys.2024.1339128
Rosenzweig R, Nillegoda NB, Mayer MP, Bu-kau B. The Hsp70 chaperone network. Nat Rev Mol Cell Biol. 2019;20(11):665-80. doi: https://doi.org/10.1038/s41580-019-0133-3
Marmett B, Carvalho RB, Dorneles GP, Nu-nes RB, Rhoden CR. Should I stay or should I go: Can air pollution reduce the health benefits of physical exercise? Med Hypotheses. 2020;144:109993. doi: https://doi.org/10.1016/j.mehy.2020.109993
Costa-Beber LC, Heck TG, Fiorin PBG, Ludwig MS. HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution. Cell Stress Chaperones. 2021;26(6):889-915.
doi: https://doi.org/10.1007/s12192-021-01241-1
Yoshihara T, Dobashi S, Naito H. Effects of preconditioning with heat stress on acute exercise-induced intracellular signaling in male rat gastrocnemius muscle. Physiol Rep. 2024;12(1):1-15. doi: https://doi.org/10.14814/phy2.15913
Akbulut T, Cinar V, Aydin S, Yardim M. The Role of Different Exercises in Irisin, Heat Shock Protein 70 and Some Biochemical Parameters. J Med Biochem. 2022;41(2):149-55.
doi: https://doi.org/10.5937/jomb0-31551
de Lemos Muller CH, Schroeder HT, Rodrigues-Krause J, Krause M. Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a syste-matic review and meta-analysis. Cell Stress Chaperones. 2023;28(6):761-71.
doi: https://doi.org/10.1007/s12192-023-01368-3
Cumming KT, Kvamme NH, Schaad L, Ugel-stad I, Raastad T. Muscular HSP70 content is higher in elderly compared to young, but is normalized after 12 weeks of strength training. Eur J Appl Physiol. 2021;121(6):1689-99. doi: https://doi.org/10.1007/s00421-021-04633-4
Mazhari M, Matinhomaee H, Fatolahi H. The Effect of high-intensity interval training with caloric res-triction on gene expression of apoptosis indices HSP70 and HSP60 in the myocardium of male rats. J Shahrekord Univ Med Sci. 2024;26(1):14-9. doi: https://doi.org/10.34172/jsums.839
Wang D, Ripley-Gonzalez JW, Hu Y. Aerobic Physical Training Protects the Rat Brain Against Exercise-Heat Related Oxidative Damage through the Increased Expression of HSP70. Neurophysiology. 2019;51(2):66-71. doi: https://doi.org/10.1007/s11062-019-09794-9
Medica P, Cravana C, Rp G, Marino A, Am F. Serum Heat Shock Protein (HSP70) Changes In Horses After An Acute Exercise. Annals of Veterinary Science. 2021:1-9. doi: https://doi.org/10.31829/2691-5502/avs2021-4(1)-002
Goh J, Hofmann P, Aw NH, et al. Concurrent highintensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study. Transl Med Commun. 2020;5(1):4. doi: https://doi.org/10.1186/s41231-020-00056-z
Lu J, Zhang LM, Liu JJ, et al. High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle. J Physiol Sci. 2023;73(1):32.
doi: https://doi.org/10.1186/s12576-023-00884-2
Min HJ, Min SJ, Kang H, Kim KS. Differential nasal expression of heat shock proteins 27 and 70 by aerobic exercise: A preliminary study. Int J Med Sci. 2020;17(5):640-6. doi: https://doi.org/10.7150/ijms.39631
dos Santos RS, Veras FP, Ferreira DW, et al. Involvement of the Hsp70/TLR4/IL-6 and TNF-α pa-thways in delayed-onset muscle soreness. J Neurochem. 2020;155(1):29-44. doi: https://doi.org/10.1111/jnc.15006
Krüger K, Reichel T, Zeilinger C. Role of heat shock proteins 70/90 in exercise physiology and exercise immunology and their diagnostic potential in sports. J Appl Physiol. 2019;126(4):916-27. doi: https://doi.org/10.1152/japplphysiol.01052.2018
Aas SN, Hamarsland H, Cumming KT, et al. The impact of age and frailty on skeletal muscle autophagy markers and specific strength: A cross-sectional com-parison. Exp Gerontol. 2019;125:110687. doi: https://doi.org/10.1016/j.exger.2019.110687
Hu C, Yang J, Qi Z, et al. Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities. MedComm. 2022;3(3):1-39. doi: https://doi.org/10.1002/mco2.161
Schroeder HT, de Lemos Muller CH, Heck TG, Krause M, de Bittencourt PIH. The Dance of Proteostasis and Metabolism: Unveiling the Caloristatic Controlling Switch. Cell Stress Chaperones. 2024;29(1):175-200. doi: https://doi.org/10.1016/j.cstres.2024.02.002
Mahboubi H, Moujaber O, Kodiha M, Stochaj U. The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation. Cells. 2020;9(4):825. doi: https://doi.org/10.3390/cells9040825
Youn CK, Lee JH, Hariharasudhan G, et al. HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells. Cell Death Dis. 2022;13(4):1-14. doi: https://doi.org/10.1038/s41419-022-04766-0
Murao A, Aziz M, Wang H, et al. Release mechanisms of major DAMPs. Apoptosis. 2021;26(3-4):152-62. doi: https://doi.org/10.1007/s10495-021-01663-3
Nagai M, Kaji H. Thermal Effect on Heat Shock Protein 70 Family to Prevent Atherosclerotic Cardiovas-cular Disease. Biomolecules. 2023;13(5):1-15. doi: https://doi.org/10.3390/biom13050867
Lissarassa YPS, Vincensi CF, Costa-Beber LC, et al. Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways. Cell Stress Chaperones. 2020;25(3):467-79. doi: https://doi.org/10.1007/s12192-020-01087-z
Zhou L, Fang L, Tamm M, Stolz D, Roth M. Ex-tracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells. Int J Mol Sci. 2023;24(14):11700. doi: https://doi.org/10.3390/ijms241411700
Mulyani WRW, Sanjiwani MID, Sandra, et al. Chaperone-based therapeutic target innovation: Heat shock protein 70 (HSP70) for type 2 diabetes mellitus. Diabetes, Metab Syndr Obes. 2020;13:559-68. doi: https://doi.org/10.2147/DMSO.S232133
Tedesco B, Vendredy L, Timmerman V, Poletti A. The chaperone-assisted selective autophagy complex dynamics and dysfunctions. Autophagy. 2023;19(6):1619-41. doi: https://doi.org/10.1080/15548627.2022.2160564
Tedeschi V, Vinciguerra A, Sisalli MJ, Pignataro G, Secondo A. Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation. Neurobiol Dis. 2023;178:106020. doi: https://doi.org/10.1016/j.nbd.2023.106020
Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP. Roles of heat shock proteins in apoptosis, oxidative stress, human inflammatory diseases, and cancer. Pharma¬ceuticals. 2018;11(1):1-18. doi: https://doi.org/10.3390/ph11010002
Garde R, Dea A, Herwig MF, PincusD. Feedback control of the heat shock response by spatiotemporal regulation of Hsp70. J Cell Biol. 2024 Dec 2;223(12):e202401082. doi: https://doi.org/10.1083/jcb.202401082
Lubkowska A, Dudzińska W, Pluta W. Antioxidant Enzyme Activity and Serum HSP70 Concentrations in Relation to Insulin Resistance and Lipid Profile in Lean and Overweight Young Men. Antioxidants. 2023;12(3):655. doi: https://doi.org/10.3390/antiox12030655
Szerlauth A, Madácsy T, Samu GF, et al. Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide. Chem Commun. 2024;60(10):1325-8. doi: https://doi.org/10.1039/d3cc05762c
Rakic J, Jantz T, Davis R, et al. Brain Injury Brain Injury. Arch Phys Med Rehabil. 2020;95(10):e62-e63. doi: https://doi.org/10.1016/j.apmr.2014.07.194
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Medicni perspektivi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
