Analysis of the terms of development of infectious complications in patients after osteosynthesis of long bones
DOI:
https://doi.org/10.26641/2307-0404.2024.4.319302Keywords:
osteosynthesis, patients, infectious complications, osteomyelitisAbstract
Determination of the influence of the timing of infectious complications in patients after osteosynthesis of long bones and its influence on the course of the infectious process. An analysis of the treatment of 207 patients with infectious complications after osteosynthesis of long bones, who were treated at the "Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine" from 2013 to 2017 was made. The first group included 148 patients who developed infectious complications after osteosynthesis of long bones with a plate. The second group included 59 patients who developed infectious complications after osteosynthesis of long bones with a blocking intramedullary rod. In 51.5% of patients of the first group after closed fractures, infectious complications were detected in the first 6 weeks after surgery. In 43.7% of patients of this group, manifestations of the inflammatory process occurred in the period from 6 weeks to 1 year. In 4.9% of patients of the first group, the infectious process (in the form of a fistula) did not occur acutely, but after one year after osteosynthesis. In 62.2% of patients after osteosynthesis as a result of an open fracture, the first manifestations of the infectious process appeared in the first 6 weeks after the operation. In 35.6% of patients of this cohort, the infectious process occurred within 6 weeks to 1 year after the surgical intervention. In 43.2% of patients of the second group, the first manifestations of infection began immediately after the operation in the form of non-healing of the postoperative wound, and in another 24.3% – in the first 6 weeks after the intervention. In 32.4% of patients in this cohort, an infectious process occurred more than a year after the intervention against the background of a consolidated fracture and a stable fixator. After BIOS with rod as a result of open fractures, in 72.7% of patients, the infectious process began immediately after the operation in the form of non-healing of the postoperative wound, and in another 27.3% – in the first 6 weeks after the intervention. The terms of the infection after osteosynthesis and its type reliably affect the development of complications in the injured person and have an indirect effect on their development. The structure of infectious complications is different depending on the time of occurrence and the type of osteosynthesis used to treat patients. In all observation groups, the infectious process localized in the tibia, which has both anatomical reasons and reasons related to the blood supply of this segment, was detected the most often.
References
Prada C, Marcano-Fernández FA, Schemitsch EH, et al. Timing and management of surgical site infections in patients with open fracture wounds: a fluid lavage of open wounds cohort secondary analysis. J Orthop Trauma. 2021;35:128-35. doi: https://doi.org/10.1097/BOT.0000000000001912
Depypere M, Morgenstern M, Kuehl R, Senneville E, Moriarty TF, Obremskey WT, et al. Pathogenesis and management of fracture-related infection. Clin Microbiol Infect. 2020 May;26(5):572-8. doi: https://doi.org/10.1016/j.cmi.2019.08.006
Foster AL, Moriarty TF, Trampuz A, Jaiprakash A, Burch MA, Crawford R, et al. Fracture-related infection: current methods for prevention and treatment. Expert Rev Anti Infect Ther. 2020 Apr;18(4):307-21. doi: https://doi.org/10.1080/14787210.2020.1729740
Morgenstern M, Moriarty TF, Kuehl R, Richards RG, McNally MA, Verhofstad MHJ, et al. International survey among orthopaedic trauma surgeons: lack of a definition of fracture-related infection. Injury. 2018;49:491-6. doi: https://doi.org/10.1016/j.injury.2018.02.001
Mishra P, Pandey CM, Singh U, Keshri A, Saba-retnam M. Selection of appropriate statistical methods for data analysis. Ann Card Anaesth. 2019 Jul-Sep;22(3):297-301. doi: https://doi.org/10.4103/aca.ACA_248_18
Ma T, Lyu J, Ma J, Huang X, Chen K, Wang S, et al. Comparative analysis of pathogen distribution in patients with fracture-related infection and periprosthetic joint infection: a retrospective study. BMC Musculoskelet Disord. 2023 Feb 13;24(1):123. doi: https://doi.org/10.1186/s12891-023-06210-6
Onsea J, Pallay J, Depypere M, Moriarty TF, Van Lieshout EMM, Obremskey WT, et al. Intramedullary tis-sue cultures from the Reamer-Irrigator-Aspirator system for diagnosing fracture-related infection. J Orthop Res. 2021;39(2):281-90. doi: https://doi.org/10.1002/jor.24816
Moriarty TF, Schmid T, Post V, Samara E, Kates S, Schwarz EM, et al. A large animal model for a failed two-stage revision of intramedullary nail-related infection by methicillin-resistant Staphylococcus aureus. Eur Cell Mater. 2017 Aug 30;34:83-98. doi: https://doi.org/10.22203/eCM.v034a06
He SY, Yu B, Jiang N. Current Concepts of Fracture-Related Infection. Int J Clin Pract. 2023 Apr 25;2023:4839701. doi: https://doi.org/10.1155/2023/4839701
Govaert GAM, Kuehl R, Atkins BL, Trampuz A, Morgenstern M, Obremskey WT, et al. Diagnosing fracture-related infection: current concepts and recom¬men-dations. J Orthop Trauma. 2019;34(1):8-17. doi: https://doi.org/10.1097/BOT.0000000000001614
Mertens B, Van Daele R, Depypere M, Lagrou K, Debaveye Y, Wauters J, et al. Isavuconazole in the Treatment of Aspergillus fumigatus Fracture-Related Infection: Case Report and Literature Review. Antibiotics (Basel). 2022 Mar 5;11(3):344. doi: https://doi.org/10.3390/antibiotics11030344
Li J, Lai YX, Li MX, Chen XY, Zhou M, Wang WZ, et al. Repair of infected bone defect with clindamycin-tetrahedral DNA nanostructure complex-loaded 3D bioprinted hybrid scaffold. Chem Eng J. 2022;435:134855. doi: https://doi.org/10.1016/j.cej.2022.134855
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