Cerebral venous thrombosis and depression: a scoping review
DOI:
https://doi.org/10.26641/2307-0404.2024.4.319342Keywords:
cerebral venous thrombosis, depression, comorbidities, outcomes, scoping reviewAbstract
Cerebral venous thrombosis is a rare condition involving thrombus formation in the venous sinuses of the brain, leading to impaired venous drainage, increased intracranial pressure, and brain damage. Depression frequently accompanies cerebral venous thrombosis patients with varying prevalence and characteristics across studies. This scoping review aims to synthesize current evidence on the prevalence and characteristics of depression among cerebral venous thrombosis patients, identify patterns of sinus involvement, and assess the impact on clinical and psychiatric outcomes. This study searched PubMed/MEDLINE, Embase, Scopus, Web of Science, and Google Scholar databases for case reports, retrospective studies, and clinical trials published within the last 20 years in articles related to depression and cerebral vein thrombosis. This review covered demographics, clinical characteristics, structural involvement, and outcomes. The prevalence of depression in patients with cerebral venous thrombosis ranged from 13% to 58.4%, influenced by factors such as pattern of venous sinus involvement, other body systemic involvement, and individual characteristics. Patients were predominantly younger to middle-aged adults, with a significant female predominance. Common comorbidities were anemia, hyperhomocysteinemia, migraines, and hypertension. Most patients had favorable outcomes; however, persistent residual symptoms and variable clinical presentations were also noted, affecting long-term quality of life. The review highlights the need for standardized assessments and a multidisciplinary approach to cerebral venous thrombosis management, addressing both neurological and psychiatric aspects. Further research with larger, standardized studies is necessary to better understand the relationship between cerebral venous thrombosis and depression and to improve patient outcomes.
References
Zhou LW, Yu AYX, Ngo L, Hill MD, Field TS. Incidence of Cerebral Venous Thrombosis: A Population-Based Study, Systematic Review, and Meta-Analysis. Stroke [Internet]. 2023 [cited 2024 Sep 1];54:169-77. doi: https://doi.org/10.1161/STROKEAHA.122.039390
Coutinho JM, van de Munckhof A, Aguiar de Sousa D, Poli S, Aaron S, Arauz A, et al. Reducing the global burden of cerebral venous thrombosis: An international research agenda. Int J Stroke [Internet]. 2024 [cited 2024 Sep 1];19:599-610. doi: https://doi.org/10.1177/17474930241242266
Aguiar de Sousa D, Lucas Neto L. Advances in Cerebral Venous Thrombosis. Stroke [Internet]. 2024 [cited 2024 Sep 1];55:2169-72. doi: https://doi.org/10.1161/STROKEAHA.123.044266
Quealy JB. Mechanical Thrombectomy for Aseptic, Atraumatic, Medically Refractory Cerebral Venous Sinus Thrombosis: a Systematic Review. Clin Neuroradiol [Internet]. 2024 [cited 2024 Sep 1];34:451-63. doi: https://doi.org/10.1007/s00062-023-01373-0
Sriram S, Asokan K, Thomas TS. Study on the Health Related Quality of Life of Patients with Ischemic stroke. IOSR J Pharm Biol Sci. 2015;10:45-52. doi: https://doi.org/10.9790/3008-10134552
Hackett ML, Pickles K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke [Internet]. 2014 [cited 2024 Sep 1];9:1017-25. doi: https://doi.org/10.1111/ijs.12357
Thorat N, Onkarappa SA, Karkal RN. Depression and quality of life after cerebral venous sinus thrombosis. J Neurol Sci [Internet]. 2019 [cited 2024 Oct 20];405:70-1. doi: https://doi.org/10.1016/j.jns.2019.10.351
Rosovsky RP, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, et al. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress-related neural mechanisms. Am J Hematol. 2024;99(10):1927-38. doi: https://doi.org/10.1002/ajh.27427
Jørgensen H, Horváth-Puhó E, Laugesen K, Brækkan SK, Hansen J-B, Sørensen HT. Venous thromboembolism and risk of depression: a population-based cohort study. J Thromb Haemost [Internet]. 2023 [cited 2024 Sep 2];21:953-62. doi: https://doi.org/10.1016/j.jtha.2022.12.006
Li H-Y, Wang L-H, Wang J, Wang Y-B, Wang H-S. Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study. Front Genet [Internet]. 2024 [cited 2024 Sep 2];15:1383333. doi: https://doi.org/10.3389/fgene.2024.1383333
Takeshima M, Ishikawa H, Umeta Y, Kudoh M, Umakoshi A, Yoshizawa K, et al. Prevalence of Asy¬mp-tomatic Venous Thromboembolism in Depressive Inpa-tients. Neuropsychiatr Dis Treat [Internet]. 2020 [cited 2024 Sep 2];16:579-87. doi: https://doi.org/10.2147/NDT.S243308
Medeiros GC, Roy D, Kontos N, Beach SR. Poststroke depression: A 2020 updated review. Gen Hosp Psychiatry. 2020;66:70-80. doi: https://doi.org/10.1016/j.genhosppsych.2020.06.011
Ashorobi D, Ameer MA, Fernandez R. Thrombosis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Sep 2]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538430/
Idiculla PS, Gurala D, Palanisamy M, Vijayakumar R, Dhandapani S, Nagarajan E. Cerebral Venous Thrombosis: A Comprehensive Review. Eur Neurol [Internet]. 2020 [cited 2024 Sep 2];83:369-79. doi: https://doi.org/10.1159/000509802
Patwardhan A, Gupta M, Philip M, Ranga-rajan A, Joshi T, Alladi S, et al. Clinicoradiological Features and Long-term Cognitive and Functional Out-come in Patients with Deep Cerebral Venous Thrombosis. Ann Indian Acad Neurol [Internet]. 2024 [cited 2024 Sep 7];27:34. doi: https://doi.org/10.4103/aian.aian_792_23
Meher R, Aghoram R, Narayan S, Done I, Bala-chandran M, Jain S, et al. Journal of Cardiovascular Disease Research. Long-term outcomes of patients with cerebral venous sinus thrombosis from tamil nadu. J Cardiovasc Dis Res. 2024;15:793-804.
Teixeira JMS. Quality of Life after Cerebral Venous Thrombosis. U.Porto. Repositorio aberto [Inter-net]. 2023 [cited 2024 Sep 7]. Available from: https://repositorio-aberto.up.pt/handle/10216/150322
Malone M, Ritchie D, Okonoboh P, Ebrahim A. An Atypical Presentation of Cerebral Venous Sinus Thro-mbosis in a 19-Year-Old Woman. Consultant. 2023;63:1-8. doi: https://doi.org/10.25270/con.2023.08.000001
Pleșa FC, Jijie A, Toma GS, Ranetti AE, Ma-nole AM, Rotaru R, et al. Challenges in Cerebral Venous Thrombosis Management-Case Reports and Short Lite-rature Review. Life Basel Switz. 2023;13:334. doi: https://doi.org/10.3390/life13020334
Benerji T, Bandla S, Parvathaneni KM. Depression in a case of cerebral venous sinus thrombosis. Arch Ment Health [Internet]. 2023 [cited 2024 Sep 7];24:149. doi: https://doi.org/10.4103/amh.amh_68_22
Saroja AO, Thorat NN, Naik KR. Depression and Quality of Life after Cerebral Venous Sinus Thrombosis. Ann Indian Acad Neurol [Internet]. 2020 [cited 2024 Sep 7];23:487-90. doi: https://doi.org/10.4103/aian.AIAN_191_19
Hiltunen S. Cerebral venous thrombosis: clinical characteristics and factors affecting outcome. Helsinki: Helsingin yliopisto; 2018.
Lindgren E, Jood K, Tatlisumak T. Vocational outcome in cerebral venous thrombosis: Long-term follow-up study. Acta Neurol Scand [Internet]. 2018 [cited 2024 Sep 7];137:299-307. doi: https://doi.org/10.1111/ane.12875
Hiltunen S, Putaala J, Haapaniemi E, Tatlisumak T. Long-term outcome after cerebral venous throm-bosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients. J Neurol. 2016;263:477-84. doi: https://doi.org/10.1007/s00415-015-7996-9
Iannacchero R, Costa A, Sergi A, Squillace A, Vescio G, Cannistrà U. Diagnosis and treatment of headache probably attributed to cerebral venous sinus throm¬bosis. Clin Manag Issues [Internet]. 2014 [cited 2024 Sep 7];8:97-101. doi: https://doi.org/10.7175/cmi.v8i4.966
Bugnicourt J-M, Guegan-Massardier E, Roussel M, Martinaud O, Canaple S, Triquenot-Bagan A, Wallon D, Lamy C, Leclercq C, Hannequin D, et al. Cognitive impairment after cerebral venous thrombosis: a two-center study. J Neurol. 2013;260:1324-31. doi: https://doi.org/10.1007/s00415-012-6799-5
Bugnicourt J-M, Garcia P-Y, Canaple S, Lamy C, Godefroy O. Central neuropathic pain after cerebral ve-nous thrombosis is not so uncommon: an observational study. J Neurol. 2011;258:1150-6. doi: https://doi.org/10.1007/s00415-010-5899-3
Koopman K. Clinical and haematological aspects of cerebral venous thrombosis. Denderen, University of Groningen; 2009.
Buccino G, Scoditti U, Patteri I, Bertolino C, Mancia D. Neurological and cognitive long-term outcome in patients with cerebral venous sinus thrombosis. Acta Neurol Scand [Internet]. 2003 [cited 2024 Sep 7];107:330-5. doi: https://doi.org/10.1034/j.1600-0404.2003.00031.x.
Lee CW-S, Liao C-H, Lin C-L, Liang J-A, Sung F-C, Kao C-H. Depression and risk of venous thrombo-embolism: a population-based retrospective cohort study. Psychosom Med. 2015;77:591-8. doi: https://doi.org/10.1097/PSY.0000000000000193
Dash D, Prasad K, Joseph L. Cerebral venous thrombosis: An Indian perspective. Neurol India [Internet]. 2015 [cited 2024 Sep 6];63:318. doi: https://doi.org/10.4103/0028-3886.158191
Zhao S, Zhu L, Yang J. Association between depression and macrovascular disease: a mini review. Front Psychiatry [Internet]. 2023 [cited 2024 Sep 6];14. doi: https://doi.org/10.3389/fpsyt.2023.1215173
Amadio P, Sandrini L, Zarà M, Barbieri SS, Ieraci A. NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity. Redox Biol. 2024;70:103060. doi: https://doi.org/10.1016/j.redox.2024.103060
Hoirisch-Clapauch S, Nardi AE. Antidepressants: bleeding or thrombosis? Thromb Res. 2019;181(Suppl 1):S23-S28. doi: https://doi.org/10.1016/S0049-3848(19)30362-7
Nieuwsma JA, Pepper CM, Maack DJ, Birgen-heir DG. Indigenous perspectives on depression in rural regions of India and the United States. Transcult Psychiatry. 2011;48:539-68. doi: https://doi.org/10.1177/1363461511419274
Bhattacharya A, Camacho D, Kimberly LL, Lukens EP. Women's Experiences and Perceptions of Depression in India: A Metaethnography. Qual Health Res. 2019;29:80-95. doi: https://doi.org/10.1177/1049732318811702
Pandian JD, Srivastava MVP, Aaron S, Ranawa-ka UK, Venketasubramanian N, Sebastian IA, et al. The burden, risk factors and unique etiologies of stroke in South-East Asia Region (SEAR). Lancet Reg Health Southeast Asia [Internet]. 2023 [cited 2024 Aug 21];17:100290. doi: https://doi.org/10.1016/j.lansea.2023.100290
Bagan AT, Crassard I, Drouet L, Barbieux-Guillot M, Marlu R, Robinet-Borgomino E, et al. Cerebral Ve-nous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT) – Comparison With ISCVT Cohort. Front Neurol [Internet]. 2021 [cited 2024 Aug 21];12:753110. doi: https://doi.org/10.3389/fneur.2021.753110
Frajerman A, Chevance A, Chaumette B, Morvan Y. Prevalence and factors associated with depression and suicidal ideation among French students in 2016: A national study. Psychiatry Res. 2023;326:115263. doi: https://doi.org/10.1016/j.psychres.2023.115263
Arvind BA, Gururaj G, Loganathan S, Amudhan S, Varghese M, Benegal V, et al. Prevalence and socioeconomic impact of depressive disorders in India: multisite population-based cross-sectional study. BMJ Open [Internet]. 2019 [cited 2024 Aug 20];9:e027250. doi: https://doi.org/10.1136/bmjopen-2018-027250
Allroggen H, Abbott RJ. Cerebral venous sinus thrombosis. Postgrad Med J [Internet]. 2000 [cited 2024 Sep 6];76:12-5. doi: https://doi.org/10.1136/pmj.76.891.12
Lan D, Song S, Jia M, Wang M, Jiao B, Liu Y, et al. Cerebral Venous-Associated Brain Damage May Lead to Anxiety and Depression. J Clin Med [Internet]. 2022 [cited 2024 Aug 21];11:6927. doi: https://doi.org/10.3390/jcm11236927
Mu J, Li J. Analysis of radiological features in pa-tients with post-stroke depression and cognitive impairment. Rev Neurosci [Internet]. 2024 [cited 2024 Sep 7];35:565-73. doi: https://doi.org/10.1515/revneuro-2023-0120.
Saadatnia M. Imaging of Cerebral Venous and Sinus Thrombosis: Galen Med J [Internet]. 2016 [cited 2024 Sep 7];5:e585-e585. doi: https://doi.org/10.31661/gmj.v5i.585
Grajny K, Pyata H, Spiegel K, Lacey EH, Xing S, Brophy C, et al. Depression Symptoms in Chronic Left Hemisphere Stroke Are Related to Dorsolateral Prefrontal Cortex Damage. J Neuropsychiatry Clin Neurosci [Internet]. 2016 [cited 2024 Sep 7];28:292-8. doi: https://doi.org/10.1176/appi.neuropsych.16010004
Robinson RG, Jorge RE, Starkstein SE. Poststroke Depression: An Update. J Neuropsychiatry Clin Neurosci [Internet]. 2024 [cited 2024 Sep 7];36(1):22-35. doi: https://doi.org/10.1176/appi.neuropsych.21090231
Harciarek M, Mańkowska A. Hemispheric stroke: Mood disorders. Handb Clin Neurol. 2021;183:155-67. doi: https://doi.org/10.1016/B978-0-12-822290-4.00007-4
Carson AJ, MacHale S, Allen K, Lawrie SM, Den-nis M, House A, et al. Depression after stroke and lesion location: a systematic review. Lancet Lond Engl. 2000;356:122-6. doi: https://doi.org/10.1016/S0140-6736(00)02448-X
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