Diagnostics of disorders of mucociliary clearance in patients with chronic obstructive pulmonary disease by determining content of medium weight molecules in sputum.
DOI:
https://doi.org/10.26641/2307-0404.2014.4.35589Keywords:
mucociliary clearance, chronic obstructive pulmonary disease, medium weight moleculesAbstract
Investigation of mucociliary clearance (MCC) condition in 90 patients with COPD was performed according to the stage of the disease by determining the level of biochemical indicator of sputum - medium weight molecules (MWM). To determine the effect of chronic inflammation in the respiratory tract on a general condition of the organism, MWM content in blood serum was investigated. To reduce the influence of comorbidity on MWM content in blood serum, patients with COPD without or with mild comorbidity in remission were selected, and the results were compared with those of healthy people (control group, n = 20). The results showed a direct correlation between the severity of airflow limitation and concentration of MWM in sputum, this was accompanied by increasing of viscosity and adhesive performance of sputum and violation of the optimal conditions of MCC functioning. The fact established allows to use determination of MWM content in sputum of COPD patients as a noninvasive and accessible for pulmonology practice method, which allows to quickly and adequately assess MCC condition and aggregate of metabolic abnormalities in patients’ respiratory tract. Chronic inflammation in respiratory tract is accompanied by disorders of determined indicators in the serum as well, but increase of MWM content in sputum is specific, while the accumulation of MWM in serum of patients with COPD is not specific.References
Карякина Е. В. Молекулы средней массы как интегральный показатель метаболических нарушений: обзор литературы / Е. В. Карякина, С. В. Белова // Клинич. лаб. диагностика. – 2004. – № 3. – С. 3–8.
Кобылянский В. И. Методы исследования мукоцилиарной системы: возможности и перспективы / В. И. Кобылянский // Терапевт. архив. – 2001. – № 3. – С. 73–76.
Савченко В.М. Стандартизація діагностичного процесу у хворих на хронічний обструктивний брон¬хіт на етапі відновлювального лікування: автореф. дис. на здобуття наук. ступеня д-ра мед. наук: спец. 14.01.27 «Пульмонологія» / В.М. Савченко. – Ялта, 2003. – 42 с.
Юнкеров В. И. Математико-статистическая об¬ра¬ботка данных медицинских исследований / В.И. Юн¬керов, С. Г. Григорьев. – СПб.: ВМедА, 2002. – 266 с.
Фещенко Ю.И. Хронические обструктивные заболевания легких / Ю.И. Фещенко, Л.А. Яшина, Н.Г. Горовенко – К.: Морион, 2002. – 79 с.
Chung K. F. Multifaceted mechanisms in COPD: inflammation, immunity and tissue repair and destruction / K. F. Chung, I. M. Adcock // Eur. Resp. J. – 2008. – Vol. 31. – P. 1334–1356.
Cole P. Pathophysiology and treatment of airway mucociliary clearance. A moving tale / P. Cole // Minerva anestesiology. – 2001. – Vol. 67, N 4. – P. 206–209.
Fahy J.V. Airway mucus function and dysfun¬ction / J.V. Fahy, B.F.N. Dickey // Engl. J. Med. – 2010. – Vol. 12.– P. 2233-2247.
Marchetti N. Preventing acute exacerbations and hospital admissions in COPD / N. Marchetti, G.J. Criner, R.K. Albert // Chest. – 2013. – Vol. 5. – P. 1444-1454.
Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects / W. Möller, K. Häussinger, R. Winkler-Heil [et al.] // J. Appl. Physiology. – 2004. – Vol. 97, N 6. – P. 2200–2206.
Rogers D. F. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options / D.F. Ro¬gers // Pulmonary Pharmacology Therapeutics. – 2005. – Vol. 18, N 1. – P. 1–8.
Schans C.P. Airway clearance: assessment of techniques / C. P. Schans // Paediatric Resp. Review. – 2002. – Vol. 3, N 2. – P. 110–114.
Voynow J.A. Mucins, mucus, and sputum / J.A. Voynow, B.K. Rubin // Chest. – 2009. – Vol. 2. – P. 505-512.
REFERENCES
Karyakina ЕV, Belova SV. [Medium weight mo¬lecules as an integral indicator of metabolic disorders: a literature review]. Clinical laboratory diagnostics. 2004;3:3–8. Russian.
Kobilyanskiy VI. [Methods of investigation of mu¬cociliary system: opportunities and perspectives]. Therapeutic Archives. 2001;3:73–76. Russian.
Savchenko VM. [Standardization of the diagnos¬tic process in patients with chronic obstructive bronchitis on the stage of restorative treatment] Abstract of dis¬sertation for a scientific degree Doctor of Medical Science, specialization 14.01.27 „pulmonology”. 2003;42. Ukrainian.
Yunkerov VI, Grigorjev SG. [Mathematical and statistical processing of data for Medical Research]. SPb: VMedA. 2002;266. Russian
Feschenko YI, Yashina LA, Gorovenko NG. [Chronic obstructive pulmonary disease]. Morion. 2002;79. Russian.
Chung KF, Adcock IM. Multifaceted mechanisms in COPD: inflammation, immunity and tissue repair and destruction. European respiratory j. 2008;31:1334–56.
Cole P. Pathophysiology and treatment of airway mucociliary clearance. A moving tale. Minerva aneste¬siology. 2001;67(4):206–9.
Fahy JV, Dickey BFN. Airway mucus function and dysfunction. Engl J Med. 2010;12:2233-47.
Marchetti N, Criner GJ, Albert RK. Preventing acute exacerbations and hospital admissions in COPD. Chest. 2013;5:1444-54.
Möller W, Häussinger K, Winkler-Heil R. Mu¬cociliary and long-term particle clearance in the airways of healthy nonsmoker subjects. J of applied physiology. 2004;97(6):2200–6.
Rogers DF. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulmonary pharmac and therap. 2005;18(1):1–8.
Schans CP. Airway clearance: assessment of techniques. Paediatric respiratory review. 2002;3(2):110–4.
Voynow JA, Rubin BK. Mucins, mucus, and sputum. Chest. 2009;2:505-12.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.
