Peculiarities of rotavirus infection in children with different genotypes of the lactase gene.
DOI:
https://doi.org/10.26641/2307-0404.2014.4.35812Keywords:
infants, rotavirus infection, lactase geneAbstract
The aim was to study the peculiarities of rotavirus infection in children with various genotypes of the lactase gene LCT. Molecular genetic studies of LCT13910 gene polymorphism by polymerase chain reaction with electrophoretic detection were determined in the Institute of Genetic and Immunological basis of pathology and pharmacogenetics of "Ukrainian Medical Stomatological Academy", Poltava. According to the results of molecular genetic studies, all children were divided into three groups: the first group included 45 children with genotype C/C-13910, the second - 22 children with genotype C/T-13910, the third - 3 children with genotype T/T-13910. It is proved that in infants with rotavirus, the most common (63%) is genotype C/C-13910 of LCT gene. It is shown that a less severe form of the disease, which in most cases occurs without fever, a less duration of vomiting syndrome, a high incidence of respiratory syndrome, a less duration of illness are the peculiarities of rotavirus infection in children with genotype C/C-13910 LCT gene. Tendency to severe course with febrile fever, severe diarrhea, a high frequency of occurrence of expressed ketone blood syndrome, longer duration of disease may be considered to be features of rotavirus infection course in children with genotype C/T-13910 LCT gene.References
Бабаян М.Л. Лактазная недостаточность: со¬временные методы диагностики и лечения / М.Л. Ба¬баян // Медицинский совет. – 2013. – № 1. – С. 24-27.
Бельмер С.В. Современный взгляд на непере¬носимость лактозы / С.В. Бельмер // Педиатрия. – 2012. – № 4. – С. 7-10.
Вторичная лактазная недостаточность в клинике ротавирусных кишечных инфекций у детей / С.В. Халиуллина, В.А. Анохин, И.А. Гутор [и др.] // Практическая медицина. – 2010. – № 6 (45). – С. 110-112.
Генетичні аспекти в патогенезі ротавірусної інфекції в дітей / І.І. Незгода, О.М. Науменко, Г.В. Макух., А.Я. Бук // Здоровье ребенка. – 2013. – № 5 (48). – http://www.mif-ua.com/archive/article/36729# prettyPhoto
Лактазная недостаточность у детей раннего возраста и ее коррекция на современном этапе / Е.Ф. Лукушкина, М.Г. Афраймович, К.А. Мошкова, Д.О. Походенько // Журнал МедиАль. – 2011. – № 2. – С. 7.
Соколова М.В. Полиморфизм C/T-13910 регуля¬торного участка гена лактазы LCT и распро¬страненность гиполактазии в популяциях Евразии / М.В. Со¬колова, Е.В. Васильев, А.И. Козлов [и др.] // Экологическая генетика. – 2007. – Т. 5, № 3. – С. 25-34.
Усенко Д.В. Лактазная недостаточность у детей / Д.В.Усенко, А.В. Горелов // Педиатрия. – 2009. – № 1. – С. 33-36.
Хавкин А.И. Лактазная недостаточность / А.И. Хав¬кин, Н.С. Жихарева // Доктор.Ру. – 2009. – № 1 (44). – С. 78-82.
Шрайнер Е.В. Лактазная недостаточность у детей: современное состояние проблемы / Е.В. Шрай¬нер, М.Ю. Денисов // Вестник Новосибирск. гос. ун-та. Серия: Биология, клиническая медицина. – 2009. – Т. 7, № 4. – С. 154-162.
Яхонтова О.И. Распространенность дефицита лактазы среди населения северо-западного региона россии / О.И. Яхонтова, Л.Н. Валенкевич // Эксперим. и клинич. гастроэнтерология. – 2005. – № 1. – С. 97-100.
Correlation of G/A -22018 single-nucleotide po¬lymorphism with lactase activity and its usefulness in improving the diagnosis of adult-type hypolactasia among North Indian children / R.A. Kuchay, M. Anwar, B.R. Thapa [et al.] // Genes Nutr. – 2013. – Vol. 8, N 1. – P. 145-51.
Identification of a variant associated with adult-type hypolactasia / N.S. Enattah, T. Sahi, E. Savilahti // Nat. Genet. – 2002. – Vol. 30, N 2. – P. 233-237.
Lactose malabsorption and intolerance: patho¬genesis, diagnosis and treatment / B. Misselwitz, D. Pohl, H. Frühauf, [et al.] // United Eur. Gastroenterol J. – 2013. – Vol. 1, N 3. – P. 151-159.
Mattar R. Lactose intolerance: diagnosis, genetic, and clinical factors / R. Mattar, de D.F. Campos Mazo, F.J. Carrilho // Clin. Exp. Gastroenterol. – 2012. – Vol. 5. – P. 113-121.
Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference / A. Gasbarrini, G.R. Corazza, G. Gasbarrini, [et al]; 1st Rome H2-Breath Testing Consensus Conference Working Group// Aliment Pharmacol Ther. – 2009. – Vol. 29, Suppl 1. – P.1-49.
Premature delivery reduces intestinal cyto¬ske¬leton, metabolism, and stress response proteins in new¬born formula-fed pigs / P. Jiang, J.M. Wan, M.S. Cilie¬borg, W.H. Sit [et al.] // J. Pediatr. Gastroenterol. Nutr. – 2013. – Vol. 56, N 6. – P. 615-622.
Systemic lactose intolerance: a new perspective on an old problem / S.B. Matthews, J.P. Waud, A.G. Ro¬berts, A.K. Campbell // Postgrad. Med. J. – 2005 – Vol. 81, N 953. – P. 167-173.
Transcriptional downregulation of the lactase (LCT) gene during childhood / H. Rasinperä, M. Kuok¬kanen, K.L. Kolho, H. Lindahl [et al.] // Gut. – 2005. – Vol. 54, N 11. – P. 1660-1661.
Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia / M. Kuokkanen, N.S. Enattah, A. Ok¬sa¬nen, E. Savilahti [et al.] // Gut. – 2003. – Vol. 52, N 5. – P. 647-652.
The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation / R. Fang, N.A. Santiago, L.C. Olds, E. Sibley // Gastro¬enterology. – 2000. –Vol. 118, N 1. – P. 115-127.
The lactase persistence/non-persistence polymo¬r¬phism is controlled by a cis-acting element / Y. Wang, C.B. Harvey, W.S. Pratt, V.R. Sams [et al] // Hum. Mol. Genet. – 1995. – Vol. 4, N 4. – P. 657-662.
The origins of lactase persistence in Europe / Y. Itan, A. Powell, M.A. Beaumont, J. Burger [et al.] // PLoS Comput Biol. – 2009. – Vol. 5, N 8. – P. e1000491.
REFERENCES
Babayan ML. [Lactase deficiency: modern me¬thods of diagnosis and treatment]. Medical council. 2013;1:24-27. Russian.
Belmer SV. [A modern view on intolerance of lactose]. Pediatrics. Annex to the Consilium Medicum magazine. 2012;4:7-10. Russian.
Khaliullina NE, VA Anokhin, Gutor IA, Amerkhanova AM Alyoshkin AB. [Secondary lactase defi¬ciency in the clinical picture of rotavirus intestinal infec¬tions in children]. Practical medicine. 2010;6(45):110-2. Russian.
Nezgoda ІІ, Naumenko OM, Makuh GV, Buk AJa. [Genetic aspects in the pathogenesis of rotavirus infection in children]. Zdorov'e rebenka. 2013;5(48). Available from: http://www.mif-ua.com/archive/ article/36729# prettyPhoto. Ukrainian.
Lukushkina EF, Afraymovich MG, Moshkova KA, Pokhodenko DO. [Lactose insufficiency in children of early age and its correction at a modern stage]. Zhurnal MediAl'. 2011;2:7. Russian.
Sokolova MV, Vasil'ev EV, Kozlov AI, Rebrikov DV, Senkeevu SS, Kozhekbaeva ZhM, Ljundup V, Sve¬chnikova NS, Ogurcov PP, Husnutdinova JeK, Jankovskij NK, Borinskaja SA. [Polymorphism C/T-13910 of regulatory region of the lactase gene LCT and the prevalence of hypolactasia in populations of Eurasia]. Jekologicheskaja genetika. 2007;5(3):25-34. Russian.
Usenko DV, Usenko DV, Gorelov AV. [Lactase deficiency in
children]. Pediatrics, 2009;1:33-6. Russian
Khavkin AI,Havkin AI, Zhihareva NS. [Lactase deficiency]. Doktor.Ru. 2009;1(44):78-82. Russian.
Schreiner U, Denisov MJ. [Lactase deficiency in children: current state of the problem]. Bulletin of the Novosibirsk State University. Series: Biology, Clinical Medicine. 2009;7(4):154-62. Russian.
Yakhontova OI. Valenkevich LN. [Prevalence of lactase deficiency among the population of the north-western region of Russia]. Experimental and clinical gastroenterology. 2005;1:97-100. Russian.
Kuchay RA, Anwar M, Thapa BR, Mahmood A, Mahmood S. Correlation of G/A -22018 single-nucleotide polymorphism with lactase activity and its usefulness in improving the diagnosis of adult-type hypolactasia among North Indian children. Genes Nutr. 2013;8(1):145-51. doi: 10.1007/s12263-012-0305-7.
Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I. Identification of a variant associated with adult-type hypolactasia. Nat Genet. 2002 Feb;30(2):233-7.
Misselwitz B, Pohl D, Frühauf H, Fried M1, Vavricka SR, Fox M. Lactose malabsorption and into¬lerance: pathogenesis, diagnosis and treatment. United European Gastroenterol J. 2013;1(3):151-9. doi: 10.1177/2050640613484463.
Mattar R, de Campos Mazo DF, Carrilho FJ. Lactose intolerance: diagnosis, genetic, and clinical fac¬tors. Clin Exp Gastroenterol. 2012;5:113-21. doi: 10.2147/CEG.S32368.
Gasbarrini A, Corazza GR, Gasbarrini G, Montalto M, Di Stefano M, Basilisco G, Parodi A, Usai-Satta P, Vernia P, Anania C, Astegiano M, Barbara G, Benini L, Bonazzi P, Capurso G, Certo M, Colecchia A, Cuoco L, Di Sario A, Festi D, Lauritano C, Miceli E, Nardone G, Perri F, Portincasa P, Risicato R, Sorge M. Tursi AMethodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference; 1st Rome H2-Breath Testing Consensus Conference Working Group. Aliment Pharmacol Ther. 2009;1:1-49. doi: 10.1111/j.1365-2036.2009.03951.x.
Jiang P, Wan JM, Cilieborg MS, Sit WH, Sangild PT. Premature delivery reduces intestinal cytoskeleton, metabolism, and stress response proteins in newborn formula-fed pigs. J. Pediatr Gastroenterol Nutr. 2013;56(6):615-22. doi: 10.1097/MPG. 0b013e318288cf71.
Matthews SB, Waud JP, Roberts AG, Campbell AK. Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J. 2005;81(953):167-73.
Rasinperä H, Kuokkanen M, Kolho KL, Lindahl H, Enattah NS, Savilahti E, Orpana A, Järvelä I. Transcriptional downregulation of the lactase (LCT) gene during childhood. Gut. 2005;54(11):1660-1.
Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Järvelä I. Transcriptional regulation of the lac¬tase-phlorizin hydrolase gene by polymorphisms as¬so¬ciated with adult-type hypolactasia. Gut. 2003;52(5):647-52.
Fang R, Santiago NA, Olds LC, Sibley E. The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Gas¬tro¬enterology. 2000;118(1);115-27.
Wang Y, Harvey CB, Pratt WS, Sams VR, Sarner M, Rossi M, Auricchio S, Swallow DM. The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element. Hum Mol Genet. 1995;4(4):657-62. doi: 10.1093/hmg/4.4.657.
Itan Y, Powell A, Beaumont MA, Burger J, Thomas MG. The origins of lactase persistence in Europe. PLoS Com¬put Biol. 2009;5(8):e1000491. doi: 10.1371/journal.pcbi.1000491.
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