Modern possibilities of antisecretory therapy in children.

Authors

  • T. V. Yaroshevskaya
  • N. B. Sapa
  • N. N. Kramarenko
  • S. P. Degtyar

DOI:

https://doi.org/10.26641/2307-0404.2015.4.56137

Keywords:

children, chronic gastroduodenitis, antisecretory therapy, pantoprazole

Abstract

The article deals with the problem of antisecretory therapy in children with erosive gastric and duodenal lesions usingproton pump inhibitors. Taking into account low potential of side effects and drug interactions, pantoprazole was used for antisecretory therapy. Administration of preparation in two doses, one of which is in the form of intravenous infusion, from the first day of patients’ hospital stay led to the rapid relief or significant reduction of pain. In 86% of patients pain was completely controlled by day 7 of hospital stay. More than 90% of patients during therapy showed improvement of appetite and general well-being, reduction of dyspeptic symptoms (nausea, vomiting, belching). The proposed scheme of pantoprazole administration showed high efficacy and safety in chronic erosive gastroduodenitis therapy in children with severe pain.

Author Biographies

T. V. Yaroshevskaya

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Department of Propaedeutics of Children’s Diseases
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

N. B. Sapa

CI “Dnepropetrovsk Children’s City Clinical Hospital N2 DRC” 
Sverdlova str., 29, Dnepropetrovsk, 49101, Ukraine

N. N. Kramarenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Department of Propaedeutics of Children’s Diseases
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

S. P. Degtyar

CI “Dnepropetrovsk Children’s City Clinical Hospital N2 DRC” 
Sverdlova str., 29, Dnepropetrovsk, 49101, Ukraine

References

Belousov YuV. [Pediatric Gastroenterology. Clinical lectures]. Kharkov: Fact. 2007;376. Russian. 2. Demidova AL. [Retrospective analysis of treat¬ment efficiency in patients with peptic duodenal ulcer]. Gastroenterology. 2015;1(55):7-10. Ukrainian. 3. Privorotsky VF. [Acid-related diseases in chil¬dren]. SPb.:SPb-MAPO; 2009;83. Russian. 4. Sokolnik SV. [Duodenal ulcer in children: diag¬nosis, clinical features, treatment]. Chernivtsi: Medu¬nіversitet. 2013;284. Ukrainian. 5. Shadrin OG, Gerasimyuk SI. [Peptic ulcer disease in the practice of pediatric gastroenterologist]. Suchasna gastroenterologіya. 2009;4(48):76-82. Russian. 6. Shcherbakov PL, Mikheev OM, Vasnev OS. [The use of injection form of acidity inhibitor drugs in Pediatric Gastroenterology]. Lechashchiy vrach. 2008;6:27-30. Russian. 7. Kawabata H, Habu Y, Tomioka H. Effect of different proton pump inhibitors, differences in CYP2C19 genotype and antibiotic resistance on the eradication rate of Helicobacter pylori infection by a 1-week regimen of proton pump inhibitor, amoxicillin and clarithromycin. Aliment. Pharmacol. Ther. 2003;17:259-64 8. Rimbara E, Fischbach LA, Graham DY. Optimal therapy for Helicobacter pylori infections. Nat. Rev. Gastroenterol. Hepatol. 2011;8:79-88. 9. Sachs G, Shin JM. The gastric H-K-ATPase as a drug target past, present and future. Clin. Gastro¬en¬terology. 2007;34:226-42. 10. Tack J, Talley NJ. Gastroduodenal disorders. Amer. J. Gastroenterol. 2010;105:757-63.

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Published

2015-11-25

How to Cite

1.
Yaroshevskaya TV, Sapa NB, Kramarenko NN, Degtyar SP. Modern possibilities of antisecretory therapy in children. Med. perspekt. [Internet]. 2015Nov.25 [cited 2024May3];20(4):57-61. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/56137

Issue

Vol. 20 No. 4 (2015)

Section

CLINICAL MEDICINE

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