Prognostic criteria of chronic myeloid leukemia by changes platelets sizes.

Authors

  • Y. V. Shorop
  • A. S. Tymchenko

DOI:

https://doi.org/10.26641/2307-0404.2016.1.63467

Keywords:

chronic myeloid leukemia, blast crisis, platelets, automatic hematology analyzer, platelet indices, morphometry

Abstract

In order to identify specific changes in the size of platelets in patients with chronic myeloid leukemia (CML) and assess possibility of their use as prognostic criteria for disease progression peripheral blood of 62 patients with CML was examined. The study was carried out by an automatic hematology analyzer and method of computer image analysis on micrographs of peripheral blood smears. CML patients showed an increase in mean platelet volume (parametr MPV) and the percentage of large platelets (parameter P-LCR). Measurement of platelet digital micrographs, carried out in parallel, showed an increase of variability of their size. Analysis of characteristic curves of the specificity/sensitivity showed the possibility of using the coefficient of variation and standard deviation of the natural logarithm of platelets in areas of the peripheral blood smear as a predictor of progression of CML in blast crisis phase.

Author Biographies

Y. V. Shorop

SI «Iinstitute of haematology and transfusiology NAMS Ukraine»
M. Berlinskogo st., 12, Кyiv, 04060, Ukraine

A. S. Tymchenko

SI «Iinstitute of haematology and transfusiology NAMS Ukraine»
M. Berlinskogo st., 12, Кyiv, 04060, Ukraine

References

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Published

2016-03-09

How to Cite

1.
Shorop YV, Tymchenko AS. Prognostic criteria of chronic myeloid leukemia by changes platelets sizes. Med. perspekt. [Internet]. 2016Mar.9 [cited 2024May18];21(1):35-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/63467

Issue

Section

CLINICAL MEDICINE