Airway remodeling in children with asthma, which runs on the background of intracellular infections.


  • O. E. Chernyshova
  • A. E. Abaturov



airway remodeling, persistent infections, asthma, children


The paper provided information on the impact of persistent intracellular infections, including cytomegalovirus, caused by herpes simplex virus I / II types, Epstein-Barr virus, Сhlamydophila pneumoniae and Mycoplasma pneumoniae, on airway remodeling process in the form of smooth muscle hypertrophy, enhanced formation of new vessels, epithelial cell hyperplasia, collagen deposition, sealing of the basement membrane in bronchial asthma in children. Changes of matrix metalloproteinases, tissue inhibitor of matrix proteases, transforming growth factor, autoantibodies to collagen type III, endothelin-1 in patients with asthma and their influence on the processes of morphological adjustment of airways, which lead to deterioration of the disease course in children are described. The data obtained call the need of etiopathogenetic treatment along with the basic treatment aimed to reduce airway remodeling, which enables to decrease asthma severity and reduce disability.

Author Biographies

O. E. Chernyshova

Donetsk National Medical University named after M.Gorky
Department of Pediatrics, neonatology and pediatric infections
Kyrova str., 27, Krasny Liman, Donetsk region, 84404, Ukraine

A. E. Abaturov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pediatrics 1 and medical genetics
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine


Antipkіn YuG, Nadtochіy TG. [Current views on etiopathogenesis, сlinical diagnostic and pro¬phylactic features of the inflammatory process with non-specific respiratory diseases in children (literature review)]. Perinatalogiya i pediatriya. 2011;1(45):19-23. Ukrainian. 2. Miromanova NA, Zhamsueva DR. [The value of matrix metalloprotease and transforming growth factor-β1 in the development of complicated forms of influenza in children]. Vrach-aspirant. 2013;5(60):16-22. Russian. 3. Nedel'skaya SN, Yartseva DA. [Diagnosis of asthma in young children: possible problematic issues, differential diagnosis]. Zdorov'e rebenka. 2013;2(45):26-32. Russian. 4. Nenartovich IA, Zhernosek VF. [Remodeling of the bronchiа in asthma and the possibilities of its correction]. Retsept. 2010;3(71):77-89. Russian. 5. Stroykova TR. [Clinical diagnostic value of autoantibodies to collagen type III in bronchopulmonary diseases in children: avtoref. dis. na soiskanie uch. stepeni kand. med. nauk: spets. 14.00.09 «Pediatriya»]. Astrak-han'. 2009;20. Russian. 6. Umanets' TR. [Clinical and anamnestic features of phenotypes of asthma in children]. Perinatalogiya i pediatriya. 2011;2(46):69-71. Ukrainian. 7. Doğu F, Yildiran A, Loğlu D. Serum transfor¬ming growth factor-β (TGF-β), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase (TIMP-1) levels in childhood asthma. Turk. J. Med. Sci. 2008;38(5):415-9. 8. Fixman ED, Stewart A, Martin JG. Basic mecha-nisms of development of airway structural changes in asthma. Eur. Respir. J. 2007;29:379-89. 9. Hegazy L, Salwa Abu El Hana. Circulating MMP-9 and TIMP-1 in acute exacerbations and after re¬mission induced by oral corticosteroids in asthmatic children. Egypt J. Pediatr. Allergy Immunol. 2006;4(1):23-29. 10. Kraus-Filarska M, Kosinska M, Tomcowicz A. Metal¬loproteinases and airway remodeling in asthma. Adv. Clin. Exp. Med. 2007;16(3):417–23. 11. Oikonomidi S, Kostikas K, Tsilioni I. Matrix metalloproteinases in respiratory diseases: from patho-genesis to potential clinical implications Cur. Med. Chem. 2009;16(10):1214–28.




How to Cite

Chernyshova OE, Abaturov AE. Airway remodeling in children with asthma, which runs on the background of intracellular infections. Med. perspekt. [Internet]. 2016Mar.9 [cited 2024May26];21(1):80-6. Available from: