Airway remodeling in children with asthma, which runs on the background of intracellular infections.

Authors

  • O. E. Chernyshova
  • A. E. Abaturov

DOI:

https://doi.org/10.26641/2307-0404.2016.1.63480

Keywords:

airway remodeling, persistent infections, asthma, children

Abstract

The paper provided information on the impact of persistent intracellular infections, including cytomegalovirus, caused by herpes simplex virus I / II types, Epstein-Barr virus, Сhlamydophila pneumoniae and Mycoplasma pneumoniae, on airway remodeling process in the form of smooth muscle hypertrophy, enhanced formation of new vessels, epithelial cell hyperplasia, collagen deposition, sealing of the basement membrane in bronchial asthma in children. Changes of matrix metalloproteinases, tissue inhibitor of matrix proteases, transforming growth factor, autoantibodies to collagen type III, endothelin-1 in patients with asthma and their influence on the processes of morphological adjustment of airways, which lead to deterioration of the disease course in children are described. The data obtained call the need of etiopathogenetic treatment along with the basic treatment aimed to reduce airway remodeling, which enables to decrease asthma severity and reduce disability.

Author Biographies

O. E. Chernyshova

Donetsk National Medical University named after M.Gorky
Department of Pediatrics, neonatology and pediatric infections
Kyrova str., 27, Krasny Liman, Donetsk region, 84404, Ukraine

A. E. Abaturov

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pediatrics 1 and medical genetics
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

References

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Published

2016-03-09

How to Cite

1.
Chernyshova OE, Abaturov AE. Airway remodeling in children with asthma, which runs on the background of intracellular infections. Med. perspekt. [Internet]. 2016Mar.9 [cited 2024May26];21(1):80-6. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/63480

Issue

Section

CLINICAL MEDICINE