Reproductive health of men of industrial areas: risk factors, donosological diagnostics, prevention.

Authors

  • A. M. Serdyuk
  • E. M. Bіletska
  • V. P. Stus
  • N. M. Onul

DOI:

https://doi.org/10.26641/2307-0404.2016.1.64096

Keywords:

reproductive health, men, fertility, risk, low dose influence, chemical pollution, heavy metals, prevention

Abstract

Deterioration of the environment in the XX-XXI century under the influence of chemical, physical, radiological and other factors is not only and not just an ecological catastrophe of modern times, but a direct threat to the health and life of human society as a whole. Among the most important factors influencing people's health occupy chemical the leading place, because since 1957 more than 50 million chemical substances were synthesized, but only 15% of them have a toxicological evaluation, and 30% of the diseases in Europe are associated with chemical factor (ECHA-EXA). Chemical "pressing" determines a significant reduction in the reproduction of the population of Europe, and for Ukraine itmeans a large-scale depopulation, among possible reasons of which a significant role belongs to the deterioration of the reproductive capacity of population, men in particular, and this work is devoted to this problem. On the basis of profound analysis of literature data, complex ecologic-hygienic researches we identified markers of exposure, prognosticaly significant markers of impact for the early diagnostics of disorders of male generative system in conditions of low-dose impact of xenobiotics. We achieved convincing evidence of ecologically determined character of  unogenital diseases and fertility decrease, we developed scientifically-justified principles of management of risk of development of ecologically-determined reproductive pathology in men.

Author Biographies

A. M. Serdyuk

SI «Institute of Hygiene and Medical Ecology name OM Marzeev NAMS Ukraine»
Popudrenkа st., 50, Kyiv, 02094, Ukraine

E. M. Bіletska

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

V. P. Stus

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

N. M. Onul

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

References

Balter RB, Ivanova TV, Pinkina AS. [Repro-ductive health status of women and newborns in the Volga region under different environmental load of residence]. Ambulatorno-poliklinicheskaya pomoshch' – platforma zhenskogo zdorov'ya: sb. nauch. st., po-svyashchennykh 70-letiyu osnovaniya akushersko-ginekologicheskogo otdeleniya MMU GP N 9. Samara. 2010;29-30. Russian. 2. Bіlets'ka EM, Onul NM. [The impact of environ-mental factors on the male reproductive system]. Dovkіllya ta zdorov’ya. 2011;4(59):15-19. Ukrainian. 3. Ventskіvs'kiy BM, Osadchuk SV, Ventskіvs'ka ІB. [Correction of placenta in pregnant women with placental insufficiency derived from the number of excess heavy metals in biological substrates]. Pedіatrіya, akusherstvo ta gіnekologіya. 2011;1:63-66. Ukrainian. 4. Population change regional centers, Kyiv and Sevastopol (1989-2014). Available from: http://upload.wikimedia.org/wikipedia/commons/b/ba/OblastCenterChangeUa1989-2011.png 5. Beletskaya EN, Onul NM, Glavatskaya VI. [In-dividual correction dependent ecological conditions in the critical groups of the population]. Gigiena i sanitariya. 2014;2:34-37. Russian. 6. Degtyareva TD, Katsnel'son BA, Privalova LI. [The use of biologically active substances in the pre-vention of the toxic effect of some heavy metals]. Gigiena i sanitariya. 2001;6:71-73. Russian. 7. Kachins'kiy AB. [Environmental safety Ukraine: a systematic analysis of prospects for improvement]. Kyїv: NІSD. 2001;312. Ukrainian. 8. Revich BA, Avaliani SL, Tikhonova GI. [En-vironmental epidemiology]. Moskva: Izdat. dom «Aka-demiya». 2004;384. Russian. 9. Bіlets'ka EM, Onul NM, Mikhaylova LA, Sal'ko-va NV. [Kontaminovanosti role of nutritional factors in the formation of reproductive pathology in men]. Vestnik gigieny i epidemiologii. 2012;16(1):21-25. Ukrainian. 10. Serdyuk AM, Stus' VP, Lyashenko VІ. [Ecology environmental and human safety in industrial regions of Ukraine]. Dnіpropetrovs'k: Porogi. 2011;486. Ukrainian. 11. Spirichev VB, Shatnyuk LN, Poznyakovskiy VM. [Enriched with vitamins and minerals, food products]. Novosibirsk. 2004;547. Russian. 12. Stus' VP. [The content of heavy metals in the tis-sues of the urinary tract inhabitants intensive industrial region]. Urologіya. 2006;10(4):30-37. Ukrainian. 13. Sukhikh GT, Stenyaeva NN. [Reproduction and Sexuality]. Akusherstvo i ginekologiya. 2014;7:4-8. Russian. 14. Trakhtenberg IM. [Key indicators of physiolo-gical norm in humans]. Kyev: Avitsenna. 2001;372. Russian. 15. Trakhtenberg ІM. [Preventive medical toxicology and ecology]. Kyїv: Avіtsena. 2011;120. Ukrainian. 16. Serdyuk AM, Belitskaya EN, Paran'ko NM, Shmatkov GG. [Heavy metals of the environment and their impact on women's reproductive function]. Dne¬pro-petrovsk: ART-PRESS. 2004;148. Russian. 17. Abarikwu SO. Causes and risk factors for male-factor infertility in Nigeria: a review. Afr J Reprod Health. 2013;17(4):150-66. 18. Khan MS, Zaman S, Sajjad M. Assessment of the level of trace element zinc in seminal plasma of males and evaluation of its role in male infertility. Int. J. App. Basic Med. Res. 2011;1:93-99. 19. Fatima P, Hossain MM, Rahman D, Rahman MW, Mugni CR, Sumon GM, Hossain HB, Hossain HN.Association of Blood and Semen Lead and Zinc Level with Semen Parameter in the Male Partner of Infertile Couple. Mymensingh Med J. 2015;24(3):537-41. 20. Benoff S, Jacob A, Hurley IR. Male infertility and environmental exposure to lead and cadmium. Hum. Reprod. Update. 2000;6:107-21. 21. Biletska EM, Onul NM, Onul VL. The expres-sivness of androgen-deficiency manifestations in infertile men of ecologically contrasting territories. News of science and education. 2015;7(31):15-20. 22. Meeker JD, Rossano MG, Protas B, Diamond MP, Puscheck E, Daly D. Cadmium, lead, and other me¬tals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant. Environ. Health Perspect. 2008;116:1473-9. 23. Sohrabvand F, Jafari M, Shariat M, Haghollahi F, Lotfi M. Frequency and epidemiologic aspects of male infertility. Acta Med Iran. 2015;53(4):231-5. 24. Ghassan T. Alani, Sermed S. Khonda, Hedef D. El Yaseen. Analysis of DNA damage and oxidative stress in human spermatozoa and some biochemical changes in seminal plasma and their correlation with semen quality of infertile men. The Iraqi Postgraduate Medical Journal. 2011;10(1):81-88. 25. Fatma Atig, Monia Raffa, Ben-Ali Habib, Abdel-hamid Kerkeni, Ali Saad, Mounir Ajina. Impact of se-minal trace element and glutathione levels on semen quality of Tunisian infertile men. BMC Urology. 2012;12(6). 26. Krausz C, Escamilla AR, Chianese C. Genetics of male infertility: from research to clinic. Reproduction. 2015;150(5):159-74. doi: 10.1530/REP-15-0261. 27. Türk S1, Mändar R, Mahlapuu R, Viitak A, Pu-nab M, Kullisaar T. Male infertility: decreased levels of selenium, zinc and antioxidants. J Trace Elem Med Biol. 2014;28(2):179-85. 28. Jegede AI, Offor U, Azu OO, Akinloye O. Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats. Evid Based Complement Alternat Med. - 2015;2015:130261. doi: 10.1155/2015/130261. Epub 2015 Sep 21. 29. Mendiola J, Moreno МJ, Roca М, Vergara-Juárez N. Relationships between heavy metal concentrations in three different body fluids and male reproductive para-meters: a pilot study. Environmental Health. 2011;10(6). 30. Telisman S, Colak B, Pizent A, Jurasović J., Cvitković P. Reproductive toxicity of low-level lead exposure in men. Environ. Res. 2007;105:256-66. 31. Amidu N, Owiredu WKBA, Bekoe MAT, Quaye L. The impact of seminal zinc and fructose concentration on human sperm characteristic. Journal of Medical and Biomedical Sciences. 2012;1(1):14-20. 32. WHO Laboratory Manual for the Examination and Processing of Human Semen. – 5th edition. – Geneva: WHO Press. 2010;287р.

Downloads

Published

2016-03-09

How to Cite

1.
Serdyuk AM, Bіletska EM, Stus VP, Onul NM. Reproductive health of men of industrial areas: risk factors, donosological diagnostics, prevention. Med. perspekt. [Internet]. 2016Mar.9 [cited 2024Jun.13];21(1):109-16. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/64096

Issue

Section

PREVENTIVE MEDICINE