Rare Clinical Case: Solid Pseudopapillary tumor of pancreas.


  • S. I. Karpenko
  • I. S. Shponka
  • V. F. Zavizion
  • E. M. Zavizion
  • V. R. Skoryk
  • A. V. Snisar




solid pseudopapillary tumor of pancreas, diagnostics, clinical observation


Solid pseudopapillary tumor of the pancreas (Frantz's tumor) is a very rare disease with uncertain malignant potential. This tumor occurs in young women at the age before 35 years. Asymptomatic disease course leads to growth of tumor up to the huge size. Surgery is the only treatment method applied. Histological diagnostic is complicated with similarity of tumor with neuroendocrine tumor of the pancreas. Disease is characterized with favorable prognosis. Paper shows our own clinical observation of Frantz’s tumor. During control ultrasound examination of woman aged 34 years, echo-signs of mass lesion in extraperitoneal area near the lower pole of the left kidney were diagnosed. During physical examination in the left hypochondrium a soft, atropic mass lesion 5.5x5 cm in size was diagnosed. Lesion presence is confirmed by CT assessment. Distal resection of the pancreas and splenectomy was performed. Diagnosis was verified histologically and immunohistochemically. Postoperative period is complications free. The results of CT assessment, detailed description of gross specimen and the results of histological and immunohistochemical examination are presented.

Author Biographies

S. I. Karpenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of surgery N 2

I. S. Shponka

Department of pathological anatomy and forensic medicine

V. F. Zavizion

Department of Oncology and medical radiology

E. M. Zavizion

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of surgery N 2

V. R. Skoryk

Department of pathological anatomy and forensic medicine

A. V. Snisar

Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine
Dnipropetrovsk regional clinical hospital named after. I. I. Mechnikov Dnipropetrovsk, 49044, Ukraine


Kriger AG, Karmazanovskiy GG, Gorin DS [Im-mediate and distant results of treatment of solid-pseudo-papillary tumors of the pancreas. Khirurgiya. 2012;1:19-24. Russain. 2. Maev IV, Kucheryavyy YuA. [Rare malignant tu-mors of the pancreas: a solid-pseudopapillary tumor]. Available from: http://medbe.ru/materials/podzheludoch¬naya-zheleza/redchayshie-zlokachestvennye-opukholi-podzheludochnoy-zhelezy-solidnaya-psevdopapillyarnaya-opukhol/. Russain. 3. Kriger AG, Berelavichus SV, Gorin DS, Po¬lya-kov IS. [Robot-assisted surgery for solid-pseudopapillary tumors of the pancreas (literary reference and clinical observation)]. Vestnik esperim. i klin. khirurgii. 2012;4:694-8. Russian. 4. Kurik OG, Kucher MD, Yakovenko VO, Kryu-china EA. [Pseudopapillary solid epithelial tumor of the pancreas]. Klіnіch. khіrurgіya. 2009;5:9-13. Ukrainian. 5. Zakhartseva LM, Kopchak VM, Dyatel MV, Pe-kur EA et al. [Solid-pseudopapillary neoplasia of the pancreas]. Onkologiya. 2015;17(2):107-12. Russian. 6. Dubova EA, Shchegolev AI, Mishnev OD, Ego¬rov VI. Solid-pseudopapillary tumor of the pancreas. Arkhiv patologii. 2008;1:49-52. Russain. 7. Stepanova YuA, Shchegolev AI, Karmazanovskiy GG et al. [Solid-pseudopapillary tumors of the pancreas: diagnosis and treatmen]. Khirurgiya. 2009;9:29-40. Russain. 8. Fletcher CDM. Diagnostic histopathology of tumors. 4th ed. –Philadelphia: Elsevier. 2013;2167. 9. Frantz VK. Atlas of tumor pathology. Sect. 7. In: Tumors of the pancreas. Washington: Armed Forces Institute of Pathology. 1959;32-33. 10. Vincent CPJ, Nagpal BBM, Harjai MM et al. Gruber-Frantz Tumour. MJAFI. 2003;59(4):355-7. 11. Odze RD, Goldblum JR. Surgical pathology of GI tract, liver, biliary tract and pancreas. 3rd ed. Phi-ladelphia: Elsevier Health Sciences. 2015;1612. 12. Zuriarrain A, Nir I, Bocklage Th, Rajput A. Pseu-dopapillary Tumor of the Pancreas in a 17-Year-Old Girl. J. Clin. Oncology. 2011;29(14):395-6. 13. Spătaru RI, Encules A, Popoiu MC. Gruber–Frantz tumor: a very rare pathological condition in chil-dren. Rom. J. Morphol. Embryol. 2014;55(4):1497-501. 14. Hamilton SR, Aaltonen LA, Capella C et al. World Health Organisation classificatoin of tumors. pa-thology and genetic of tumors of the digestive system. S.R. Hamilton SR, Aaltonen LA, editors. – Lyon: IARC Press. 2000;314.




How to Cite

Karpenko SI, Shponka IS, Zavizion VF, Zavizion EM, Skoryk VR, Snisar AV. Rare Clinical Case: Solid Pseudopapillary tumor of pancreas. Med. perspekt. [Internet]. 2016Mar.9 [cited 2024May29];21(1):144-8. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/64269