Biochemical parameters and adaptation of white rats with active and passive type of behavior under immobilization stress.

Authors

  • Yu. V. Fedorenko

DOI:

https://doi.org/10.26641/2307-0404.2016.2.72128

Keywords:

immobilization stress, active and passive type of behavior, biochemical parameters, adaptive processes

Abstract

The aim was to study dynamics of changes of certain biochemical indices and the development of adaptation in white rats with active and passive type of behavior under the influence of immobilization stress. Experiments were conducted on white rats, previously divided into groups of active and passive ones, on the basis of indicators of activity in the test “open field”. Modeling of immobilization stress was carried out by placing the animals in plastic boxes for 6 hours daily within 30 days. It was found that the immobilization caused changes of carbohydrate, lipid, calcium metabolism, activity of alkaline phosphatase, alanine- and aspartataminotransferase in blood serum of both experimental groups. However, the intensity, direction of the biochemical parameters, development in time depends on the type of animal behavior. To a greater degree active animals reacted to immobilization by changing of concentration of glucose and calcium in the blood on the 3rd and 5th day of the experiment, changes of all investigated parameters were observed on the 10th and 30th day of the experiment. Animals with active type of behavior appeared to be more susceptible to stress mobilization, but the intensity of their metabolic processes was higher than in animals with a passive type of behavior. This is testified by the highest level of blood glucose and lower levels of total cholesterol and triglycerides, as well as more active processes of calcium metabolism in the active animals than passive ones. Thus, dynamics of changes of biochemical parameters and the proceeding of the adaptation process in the conditions of immobilization stress depends on individually-typological features of animal behavior. This indicates to the necessity of differentiated approach to correction of adaptation disorders due to the action of immobilization stress on the organism with different typology of behavior.

Author Biography

Yu. V. Fedorenko

Danylo Halytsky Lviv National Medical University
Department of physiology
Pekarska str., 52, Lviv, 79010, Ukraine

References

Anhelski S, Dominichak MG, Iakubovskі Z. [ Clinical Biochemistry]. Translation from Polish Logіn¬s'kij VO, Lucik OD,Martinec' LL et al. Sopot, 1998;176-7. Ukraine.

Bahshalieva AJa. [ Features of development of depressive state in rats with different individual-typo-logical status]. Neirofiziologiia. 2010;42(2):153-161. Russian.

Garkavi LH, Kvakina EB, Ukolova MA. [Adap-tative reactions and resistance of the organism]. Rostov-na-Donu: Izd. RGU, 1990;223. Russian.

Grigoryan AG. [Changing the content of total lipids in the blood and body weight of the animals at a hypokinesia]. Biol.zh-l Armenii. 2012;3(64):66-69. Russian.

Іgrunova KM. [Mechanisms of heart damage under repeated stress and their correction]. Dissertation. Kyiv, 2007;50. Ukraine.

Latjushin JaV. [Laws of molecular-cellular adap-tation processes in the system of blood during acute and chronic hypokinetic stress]. Dissertation. Chelyabinsk, 2010;44. Russian.

Livanova LM, Luk'janova LD, Troshin VI. [Ef-fect of long-term adaptation to hypoxia in the behavioral responses of rats in the open field with a different type of behavior]. Zhurnal vysshei nervnoi deiatel'nosti. 1993;43(9):808. Russian.

Lomako VV, Shilo AV. [Effect of total cooling behavior of rats in the "open field"]. Problemy kriobio-logii. 2009;19(4):421-9. Russian.

Mulik AB, Postnova MV, Mulik JuA. [The level of total non-specific reactivity of the human body]. Volgograd: Volgograd, 2009;224. Russian.

Panin LE. [ Biochemical mechanisms of stress]. Novosibirsk: Nauka, 1983;233. Russian

Postnova MV. [The physiological mechanisms of the individual organization of an organism homeostasis]. Dissertation. Astrakhan, 2012;30. Russian.

Sel'e G. [ Essays about adaptative syndrome]. M., 1960;254. Russian..

Stepanchuk VV. [Immobilization stress and chro-norythms of humoral immunity in albino rats]. Zdorov'e i obrazovanie v XXI veke. 2013;15(1-4):227-9. http://cy-berleninka.ru/article/n/immobilizatsionnyy-stress-i-hrono-ritmy-gumoralnogo-immuniteta-u-belyh-krys. Russian.

Wood GE, Norris EH, Waters E, Stoldt JT, McEwen BS. Chronic immobilization stress alters aspects of emotionality and associative learning in the rat. Behav Neurosci, 2008;122(2):282-92. http://www.ncbi.nlm.-nih.gov/pubmed/18410168.

Gulsah Bitgul, Isil Tekmen, Didem Keles, Gulgun Oktay. Protective Effects of Resveratrol against Chronic Immobilization Stress on Testis. ISRN Urology Volume. 2013;10. http://www.hindawi.com/journals/isrn/2013/-278720/.

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Published

2016-05-31

How to Cite

1.
Fedorenko YV. Biochemical parameters and adaptation of white rats with active and passive type of behavior under immobilization stress. Med. perspekt. [Internet]. 2016May31 [cited 2024Dec.4];21(2):13-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/72128

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Section

THEORETICAL MEDICINE