Disorders of cardiac hemodynamic in attack period of bronchial asthma in children.


  • V. А. Kondratiev
  • А. V. Reznyk




children, cardiovascular system, hemodynamic, bronchial asthma


Bydopplerechocardiographymethodtherewasstudiedfunctionalstateofcardiacventriclesandcharacterofhemodynamicdisordersin 48 patients aged 5-17 years in attack period of moderately-severe and severe bronchial asthma. Group of comparison included 40 healthy peers. Disordersofcentralandperipheralhemodynamicinattackperiodofbronchialasthmainchildrenwereaccompaniedbothbysystolicanddiastolicdysfunctionoftheleftandrightheartventricles, herewith right ventricle was functioning in the mode of hyperdynamic, and left one – in the mode of hypodynamic. Combinedsystolic-diastolicvariantofdysfunctionbothofrightandleftventricleswasdevelopingin 58,3% of patients with moderately-severe and in 91,6% of patients with severe bronchial asthma. Intheattackperiodofbronchialasthmainchildrenequaldirectionalityofsystolicanddiastolicdysfunctionofheartventricleswasdeveloping; this was characterized by synchronization of their function.Assessmentoffunctionalinteractionoftheventriclesunderconditionsofsevereasthmaattackshoweddirectandhigh (r=0,67) correlativeinteractionbetweenfindingofTeiindexoftheleftandrightventricles, whichcharacterizetheirsystolicfunction; this, under conditions of increased hemodynamic pre-loading testified to compensatory  increase of systolic interaction of ventricles. Direct and high (r=0,69) correlativeinteractionbetween time indices of isovolumic relaxation of the left and right ventricles, characterizing their diastolic function, testified to compensatory increase of diastolic interaction of ventricles under conditions of increase of hemodynamic post-loading.  Imbalance of central and peripheral link of hemodynamic in attack period ofbronchialasthmainchildrentestified to development of cardiac insufficiency, which was compensated predominantly at the expense of increase of heart contractions rate. 

Author Biographies

V. А. Kondratiev

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of pediatrics 2
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

А. V. Reznyk

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of pediatrics 2
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine


Baranov VL, Kharitonov MA, Khrustalyova MI. [Comparative characteristic of dopplerographic in¬vesti-gations in the assessment diastolic function in patients with bronchial asthma]. Pulmonology. 2008;2:20-24. Russian.

Belyakova АV, Shyshkina MI. [State of systemic and pulmonary hemodynamic and microcirculation in bronchial asthma in children]. Pediatrics. 2008;87(4):30-33. Russian.

Vorobyov АS. [Ambulatory echocardiography in children: guide for physicians] SPb.: Spec.Lit, 2010;543. Russian.

Hrynberh NB. [Analysis and prognosis of micro-angiopathies and cardiohemodynamic remodeling in bronchial asthma: avtoref. of dissertation to obtain candidate’s degree in medicine]. Astrakhan.2011;24. Russian.

Rrybakova MК, Alekhin MN, Myt’kov VV. [Pra-ctical guide on ultrasonic diagnostics. Echocardiography] M.: Publ. house «Vidar-M», 2008;512. Russian.

Yunkerov VI, Hryhor’yev SH. [Mathematic-sta-tistic processing of data of medical researches] SPb.: VMedА, 2002;266. Russian.

GINA REPORT, Global Strategy for Asthma Management and Prevention/ revised. 2014;1-132.

Gunes Y, Guntekin U, Tuncer M [et al.]. Impro-ved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study. Heart and vessels. 2009;24(4):277-82.

Bistola V, Parissis JT, Paraskevaidis I, et al. Prog-nostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-ty¬pe natriuretic Peptide in patients with advanced heart fai¬lure secondary to ischemic or idiopathic dilated cardiomyopathy. American journal of cardiology. 2010;105(2):249-54.

Gan CT, Holverda S, Marcus JT, et al. Right ven-tricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients. Chest. 2007;132(1):11-17.




How to Cite

Kondratiev VА, Reznyk АV. Disorders of cardiac hemodynamic in attack period of bronchial asthma in children. Med. perspekt. [Internet]. 2016May31 [cited 2024May18];21(2):57-62. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/72152