Expediency of radiation therapy and adjuvant polychemotherapy in surgical treatment of cancer.

Authors

  • M. I. Khvorostenko
  • I. N. Bondarenko
  • K. V. Barannikov
  • Y. M. Khvorostenko
  • A. V. Phokhach

DOI:

https://doi.org/10.26641/2307-0404.2016.2.72159

Keywords:

gastric cancer, surgical treatment, combined method, adjuvant chemotherapy, remote survival

Abstract

The analysis of the effectiveness of different methods of treatment of patients with gastric cancer have been conducted. In additional to surgery methods of antitumor action – preoperative radiation therapy (combination therapy), adjuvant chemotherapy allowed to improve survival in patients with locally advanced gastric cancer as compared with surgical method only. On the early stages of gastric cancer surgery may be the only and final treatment. Indicators of long-term survival in usage of routine treatment options (surgery and irradiation) or adjuvant chemotherapy improved by 1.5-2 times, and were the highest in the group with combined radiotherapy (5-year survival rate - 25%). Improvement of resection proceduresin gastric cancer in combination with appearing of targeted, immunomodulatory drugs, increasing possibility of high-precision equipment improve long-term results aswell. Thus, improvement of treatment methods of gastric cancer requires search for and application of new advanced modes of systemic and combined treatment.

Author Biographies

M. I. Khvorostenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of oncology and medical radiology
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

I. N. Bondarenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of oncology and medical radiology
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

K. V. Barannikov

Shupik National Medical Academy of Postgraduate Education 
Dorogozhitskay st, 9, Kyiv, 04112, Ukraine

Y. M. Khvorostenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of oncology and medical radiology
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

A. V. Phokhach

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of oncology and medical radiology
Dzerzhinsky str., 9, Dnipropetrovsk, 49044, Ukraine

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Published

2016-05-31

How to Cite

1.
Khvorostenko MI, Bondarenko IN, Barannikov KV, Khvorostenko YM, Phokhach AV. Expediency of radiation therapy and adjuvant polychemotherapy in surgical treatment of cancer. Med. perspekt. [Internet]. 2016May31 [cited 2024Apr.20];21(2):77-81. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/72159

Issue

Section

CLINICAL MEDICINE