Expediency of radiation therapy and adjuvant polychemotherapy in surgical treatment of cancer.
DOI:
https://doi.org/10.26641/2307-0404.2016.2.72159Keywords:
gastric cancer, surgical treatment, combined method, adjuvant chemotherapy, remote survivalAbstract
The analysis of the effectiveness of different methods of treatment of patients with gastric cancer have been conducted. In additional to surgery methods of antitumor action – preoperative radiation therapy (combination therapy), adjuvant chemotherapy allowed to improve survival in patients with locally advanced gastric cancer as compared with surgical method only. On the early stages of gastric cancer surgery may be the only and final treatment. Indicators of long-term survival in usage of routine treatment options (surgery and irradiation) or adjuvant chemotherapy improved by 1.5-2 times, and were the highest in the group with combined radiotherapy (5-year survival rate - 25%). Improvement of resection proceduresin gastric cancer in combination with appearing of targeted, immunomodulatory drugs, increasing possibility of high-precision equipment improve long-term results aswell. Thus, improvement of treatment methods of gastric cancer requires search for and application of new advanced modes of systemic and combined treatment.
References
Berdov BA, Mardynskiy YuS, Skoropad VYu. [Long-term results of clinical studies of the effectiveness of pre-and intraoperative radiation therapy in the combined treatment of gastric cancer]. Voprosi oncologii. 2006;52(5):515-20. Russian.
Teryakin AA. [Treatment of locally advanced gastric cancer: the role of chemotherapy]. Prakticheskaya oncologiya. 2009;10(1):36-40. Russian.
Hartring HH, van de Velde CJ, Putter H. Ex-tended lymph node dissection for gastric cancer: who may benesit? Final results of the randomized dutch Gastric Cancer Group trial. Clin.Oncol. 2004;22:2069-77.
Pasechnikov V, Chukov S, Fedorov E. Gastric cancer: Prevention, screening and early diagnosis . World J Gastroenterol. 2014;20(38):13842-62.
Marutsuca T, Shimada S, Shimori K. Mehanisms of peritoneal metastasis after operation for non-Serosa-infasive castric carcinome: an ultrepid Direction sistem for intraperitoneal rree cancer cells and a prophlactic strategy for peritoneal metastasis. Clin. Cancer. 2003;9:678-85.
Gannigbam D, Allum WH, Stenning SP. Periope-rative chemotherapy versus surgery alone for resectable gastroesophageal cancer .N. Engl. Med. 2006;355:11-20.
Sugano K. Gastric cancer: pathogenesis, screening, and treatment. Gastrointest Endosc Clin N Am. 2008;18(3):513-22.
Miyazono F, Natsugoe S, Nakao S. Surgical ma-neures enhance molecular detection of ciculating tu-morcells duringgastric cancer surgery.Ann. Surg. 2001;233:189-94.
Fiorika F, Cartei F, Enta M. The impact of radio-therapy on survival inresectable gastric carcinoma: a meta-analysis of literature date. Cancer Treat Rev. 2007;33:729-40.
Yixing J, Jaffer A. Multidisciplinary Management of Gastric Cancer. Curr Opin Gastroenterol. 2010;26(6):640-6.
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