Toxicological and hygienic regulation and assessment of danger of the new fungicide-cyflufenamid.
DOI:
https://doi.org/10.26641/2307-0404.2016.2.72279Keywords:
cyflufenamid, fungicides, acceptable daily dose, toxicity, hazardous classAbstract
Toxicodynamic peculiarities of the new fungicide – cyflufenamid were studied. It was found that in accordance with hygienic classification of pesticides, cyflufenamid is referred to the 3rd class of hazard (moderately hazardous). It was shown that liver is the primary target organ of cyflufenamid action, thyroid gland, heart, kidneys, brain are secondary. It was established that cyflufenamid is microsomal enzyme inducer. Acceptable daily dose of cyflufenamid for humans was substantiated on level of 0,01 mg/kg.References
Antonenko AM. [Peculiarities of toxico¬dynamics and hazard assessment of new fungicide inhibitor of succinate dehydrogenase II generation – izopirazam]. Naukovyy ohlyad. 2015;2(12):85–96. Ukrainian.
Kravchenko VN, et al. [Effect of medicinal plants on iodine level of thyroid hormones in the blood of rats]. Biologicheskiy zhurnal Armenii. 2014;4(66):17–21. Russian.
Storchous I. [Ecology and pesticides]. Available from: http://www.agro-business.com.ua/agronomiia-sio-godni/838-ekologiia-i-pestytsydy.html. Ukrainian.
[Guidelines for the hygienic assessment of new pesticides]: МU N 4263-87. Approv. 13.03.87. К.: Ministry of health of USSR. 1988;210. Russian.
[Hygienic classification of pesticides according to the degree of danger]. DSanPiN 8.8.1.002-98. Approv. 28.08.98. Ministry of health of Ukraine. 1998;20. Ukrainian.
[General Toxicology] pod red. Kurlyandskogo BA, Filova VA. M.: «Meditsina». 2002;607. Russian.
Prodanchuk NH, Spynu Ye.I, Chayka YuG. [Sys-temic principle in establishing of pesticides acceptable daily intake for humans]. Gigiena i sanitariya. 2005;1:55–58. Russian.
Rozen VB. [The main pathways of peripheral metabolism: The metabolism of thyroid hormones]. Avai¬lable from: http://medbe.ru/materials/endokrinnye-funkt¬sii/osnovnye-puti-perifericheskogo-metabolizma-metabolizm-tireoidnykh-gormonov/. Russian.
Troshina Ye.A. [Principles of thyreostatic therapy of Graves' disease (lecture)]. 12(12). Available from: http://medi.ru/doc/a794704.htm. Russian.
Сyflufenamid: IUPAC. Global availability of information on agrochemicals. Available from: http://si-tem.herts.ac.uk/aeru/iupac/Reports/191.htm.
Public release summary on the Evaluation of the New Active Cyflufenamid in the Product Cyflamid 50EW Fungicide. European Food Safety Authority. Available from: http://apvma.gov.au/sites/default/files/publica-tion/13656-prs-cyflufenamid.pdf.
Reasoned Opinion on the modification of the existing MRLs for cyflufenamid in strawberries and peppers. European Food Safety Authority. Available from: http://www.efsa.europa.eu/sites/default/files/scien-tific_output/files/main_documents/3542.pdf.
Registration of the New Active Ingredient Cyf-lufenamid as Contained in Cyflufenamid Technical Fun-gicide. New York State Department of Environmental Conservation Division of Materials Management. Avai-lable from: http://pmep.cce.cornell.edu/profiles/fung-nemat/aceticacid-etridiazole/cyflufenamid/cyflufenamid_¬reg_1013.pdf.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.