Toxicological and hygienic regulation and assessment of danger of the new fungicide-cyflufenamid.

Authors

  • P. V. Stavnichenko
  • A. M. Antonenko
  • M. M. Korshun
  • V. G. Bardov

DOI:

https://doi.org/10.26641/2307-0404.2016.2.72279

Keywords:

cyflufenamid, fungicides, acceptable daily dose, toxicity, hazardous class

Abstract

Toxicodynamic peculiarities of the new fun­gicide – cyflufenamid were studied. It was found that in accordance with hygienic classification of pesticides, cyflufe­namid is referred to the 3rd class of hazard (moderately hazardous). It was shown that liver is the primary target organ of cyflufenamid action, thyroid gland, heart, kidneys, brain are secondary. It was established that cyflufenamid is mic­rosomal enzyme inducer. Acceptable daily dose of cyflufenamid for humans was substantiated on level of 0,01 mg/kg.

Author Biographies

P. V. Stavnichenko

Bogomolets National Medical University
Department of hygiene and ecology
T. Shevchenko boul., 13, Kyiv, 01601, Ukraine

A. M. Antonenko

Bogomolets National Medical University
Department of hygiene and ecology
T. Shevchenko boul., 13, Kyiv, 01601, Ukraine

M. M. Korshun

Bogomolets National Medical University
Department of hygiene and ecology
T. Shevchenko boul., 13, Kyiv, 01601, Ukraine

V. G. Bardov

Bogomolets National Medical University
Department of hygiene and ecology
T. Shevchenko boul., 13, Kyiv, 01601, Ukraine

References

Antonenko AM. [Peculiarities of toxico¬dynamics and hazard assessment of new fungicide inhibitor of succinate dehydrogenase II generation – izopirazam]. Naukovyy ohlyad. 2015;2(12):85–96. Ukrainian.

Kravchenko VN, et al. [Effect of medicinal plants on iodine level of thyroid hormones in the blood of rats]. Biologicheskiy zhurnal Armenii. 2014;4(66):17–21. Russian.

Storchous I. [Ecology and pesticides]. Available from: http://www.agro-business.com.ua/agronomiia-sio-godni/838-ekologiia-i-pestytsydy.html. Ukrainian.

[Guidelines for the hygienic assessment of new pesticides]: МU N 4263-87. Approv. 13.03.87. К.: Ministry of health of USSR. 1988;210. Russian.

[Hygienic classification of pesticides according to the degree of danger]. DSanPiN 8.8.1.002-98. Approv. 28.08.98. Ministry of health of Ukraine. 1998;20. Ukrainian.

[General Toxicology] pod red. Kurlyandskogo BA, Filova VA. M.: «Meditsina». 2002;607. Russian.

Prodanchuk NH, Spynu Ye.I, Chayka YuG. [Sys-temic principle in establishing of pesticides acceptable daily intake for humans]. Gigiena i sanitariya. 2005;1:55–58. Russian.

Rozen VB. [The main pathways of peripheral metabolism: The metabolism of thyroid hormones]. Avai¬lable from: http://medbe.ru/materials/endokrinnye-funkt¬sii/osnovnye-puti-perifericheskogo-metabolizma-metabolizm-tireoidnykh-gormonov/. Russian.

Troshina Ye.A. [Principles of thyreostatic therapy of Graves' disease (lecture)]. 12(12). Available from: http://medi.ru/doc/a794704.htm. Russian.

Сyflufenamid: IUPAC. Global availability of information on agrochemicals. Available from: http://si-tem.herts.ac.uk/aeru/iupac/Reports/191.htm.

Public release summary on the Evaluation of the New Active Cyflufenamid in the Product Cyflamid 50EW Fungicide. European Food Safety Authority. Available from: http://apvma.gov.au/sites/default/files/publica-tion/13656-prs-cyflufenamid.pdf.

Reasoned Opinion on the modification of the existing MRLs for cyflufenamid in strawberries and peppers. European Food Safety Authority. Available from: http://www.efsa.europa.eu/sites/default/files/scien-tific_output/files/main_documents/3542.pdf.

Registration of the New Active Ingredient Cyf-lufenamid as Contained in Cyflufenamid Technical Fun-gicide. New York State Department of Environmental Conservation Division of Materials Management. Avai-lable from: http://pmep.cce.cornell.edu/profiles/fung-nemat/aceticacid-etridiazole/cyflufenamid/cyflufenamid_¬reg_1013.pdf.

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Published

2016-05-31

How to Cite

1.
Stavnichenko PV, Antonenko AM, Korshun MM, Bardov VG. Toxicological and hygienic regulation and assessment of danger of the new fungicide-cyflufenamid. Med. perspekt. [Internet]. 2016May31 [cited 2024Nov.14];21(2):106-11. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/72279

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Section

PREVENTIVE MEDICINE