Quantum chemical study of the anionformation in thymidine and 5- bromouridine

Authors

  • І. А. Петрушко Uzhhorod National University, Ukraine
  • М. І. Суховія Uzhhorod National University, Ukraine

DOI:

https://doi.org/10.24144/2415-8038.2007.20.39-45

Keywords:

Thymidine, 5-bromouridine

Abstract

Electronic structure and vibration spectra of thymidine and 5- bromouridine and their transformation under anion formation were investigated by the AM1 semiempirical method. Based on the data obtained, the molecular mechanisms of the genotoxic and radiosensitization effect of the 5-bromouridine embedding into sellular DNA were specified. The comparison of the theoretical and experimental results was made.

References

International Commission on Radiation Units and Measurements, ICRU Report 31. ICRU: Washington, DC (1979).

А. Чердзби, Ядерные излучения и полимеры (Наука, Москва, 1962).

V. Cobut, Rad. Phys. Chem. 51, 229 (1998).

М.И. Суховия, И.И. Шафраньош, В кн. Механизмы радиационных повреждений и восстановления нуклеиновых кислот (Пущино-на-Оке, 1980), с. 51.

М.И. Суховия, В.Н. Славик, И.И. Шафраньош, Л.Л. Шимон, Биополимерьі и клетка 7, 77 (1991).

І.І. Шафраньош, І.А. Петрушко, В.М. Славік, М. І. Суховія, Науковий вісник Ужгородського університету. Серія фізика. 6, 259 (2000).

H. Abdoul-Carime, P. Limao-Vieira, S. Gohlke, I. Petrushko, N. J. Mason, E. Il lenberger, Chem. Phys. Letters. 393, 442 (2004).

I. Shafranyosh, M.I. Sukhoviya, J. Phys. Б: At. Mol. Opt. Phys., 39, 4155 (2006).

K. Aflatooni, G.A. Gallup, P.D. Burrow, J. Phys. Chem. A. 102, 6205 (1998).

F. Martin, P.D. Burrow, Z. Cai, P. Cloutier, D. Hunting, L. Sanche, Phys. Rev. Lett. 93, 068101 (2004).

М.Е. Лобашев, Генетика (Изд. ЛГУ, Ленинград, 1969).

Д.М. Гродзинський, Радіобіологія ( Либідь, Київ, 2001).

J. P. Henderson, J. Byun, J. Takeshita, J. W. Heinecke, J. Biol. Chem. 278, 23522 (2003).

S A. Krasnokutski, A.Yu. Ivanov, V. Izvekov, G.G. Sheina, Yu.P. Blagoi, J. Mol. Str. 482, 249 (1998).

M.J.S. Dewar, E.G. Zoebisch, E.F. Healy, J.J.P. Stewart, J. Am. Chem. Soc. 107, 3902 (1985)

D.N. Govorun, Ya.R. Danchuk, Ya.R. Mishchuk, I.V. Kondratyuk, N.F. Radomsky, N.V. Zheltovsky, J. Mol. Str. 267, 99 (1992).

І.А. Петрушко, М.І. Суховія, Біополім. кліт. 21, 440 (2005).

Н.Н. Мушкамбаров, С.Л. Кузнецов, Молекулярная биология. (Медицинское информационное агентство, Москва, 2003).

В.И. Хвостенко, Масс-спектрометрия отрицательных ионов в органической химии (Наука, Москва, 1981).

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Published

2007-06-30

Issue

Vol. 20 (2007)

Section

Статті

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Copyright (c) 2007 Scientific Herald of Uzhhorod University.Series Physics

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