Population-epidemiology aspects of the hereditary diseases of the nervous system
DOI:
https://doi.org/10.15587/2313-8416.2015.38184Keywords:
hereditary diseases of nervous system, epidemiology, genetic load, Ukrainian population, SlobozhanshchynaAbstract
Aim. One of the basic approaches to the personalized medicine, predictive, carrying out the disease foresight before its symptomatic display is presented in the paper. Within the framework of the predictive approach, the study of diseases frequency and prevalence in populations is taking on significance.
Methods. The data of hereditary neurological disorders prevalence in most studied world populations are given in the paper; the forming mechanisms of population genetic load and its change in generations have been considered. The basic evolutional processes of populations genetic model forming and importance of such factors as migrations and mutations have been considered. The description of Ukrainian population from its formation as ethnos up to the present taking into account microevolutionary process features has been given.
Result. The Ukrainian anthropological type and morphological bases of its forming have been considered. The historical stages of formation and modern features of Slobozhanshchyna, one of the Ukrainian ethnoterritorial areas have been presented. According to statistics data on 01.01.2014, the population of Slobozhanshchyna is 5 million 328 thousand people, that is 12,5% of the population of Ukraine; by a degree mono- and polyethnicity Slobozhanshchyna relates to a mixed zone with Ukrainian population predominance (from 70% to 83%) and significant portion of Russians (up to 20%); Slobozhanshchyna is the highly urbanized part of Ukraine and the most industrially and economically developed region, that forms ecological features connected with the industrialization of the region as well as a high degree of migration flows.
Conclusions. The features of Slobozhanshchyna cause the necessity of population studies of hereditary neurological disorders frequency and prevalence in the region in order to develop methods of early diagnostics and prevention that are the most optimal for Slobozhanshchyna
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