Modern strategy of treatment hypercholesterolemia
DOI:
https://doi.org/10.15587/2313-8416.2015.39266Keywords:
coronary heart disease, familial hypercholesterolemia, statins, monoclonal antibody to the proprotein convertase subtilisin/kexin type 9Abstract
Aim. The main factors of cardiovascular risk, particularly hypercholesterolemia, in patients with coronary heart disease are considered, comparative characteristic of the statins efficiency is given, and factors that determine the effectiveness of intolerance and lack of a standard hypocholesterolemia therapy are described. From the point of view of genetics is considered a promising direction of research on the development of monoclonal antibodies to the proprotein convertase subtilisin / kexin type 9, and their effect on the lipid profile in patients at high risk.
Conclusions. Statins are the main agents in the treatment and prevention of coronary heart disease. PCSK9 is an important regulator of LDL cholesterol through the effect on LDL receptors. Blocking the PCSK9 is a new mechanism in reducing LDL cholesterol
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