Ethelial-mesenchymal transformation of papillary thyroid mcrocarcinomas

Authors

  • Ирина Ивановна Яковцова Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176, Ukraine
  • Игорь Владимирович Ивахно City Multi-field Clinic Hospital № 17 pr. Moskovsky, 195, Kharkov, Ukraine, 61037, Ukraine
  • Оксана Владимировна Долгая Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176, Ukraine
  • Анрей Евгениевич Олейник Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176, Ukraine
  • Светлана Владимировна Данилюк Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2015.39327

Keywords:

papillary thyroid microcarcinomas, epithelial-mesenchymal transformation, lymph nodes metastases

Abstract

Epithelial-mesenchymal transformation (EMT) in papillary thyroid cancer results in high risk of invasion and lymph node metastasizes.  The aim of the study was to investigate the immunohistochemical features of EMT in papillary thyroid microcarcinomas (PTM) for identify morphological diagnostic features of tumor aggressive clinical behavior.

Methods. The immunohistochemical expression patterns of vimentin were examinated in central regions, invasion zones and lymph node metastases in 28 patients with PTM. It is investigated an expression of NIS, VEGF, MMP-9 and pan-cytokeratin in PTM with solid/trabecular pattern of growth and high level expression of vimentin.

Results. It is shown that microcarcinomas with high level expression of vimentin, exhibiting a solid/trabecular pattern of growth associated with increase MMP-9 (p<0,005), VEGF (р<0,05), and decrease NIS (р<0,005) level expression. These changes reflect phenotype of the epithelial-mesenchymal transformation and associated with the presence of metastases in  cervical lymph nodes (p<0,001).

Conclusions. Epithelial-mesenchymal transformation which can be seen under routine H&E observation is an important indicator of lymph node metastasis of PTM.

Author Biographies

Ирина Ивановна Яковцова, Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176

doctor of medical sciences, professor

Department of Pathology

Игорь Владимирович Ивахно, City Multi-field Clinic Hospital № 17 pr. Moskovsky, 195, Kharkov, Ukraine, 61037

doctor-pathologist

Оксана Владимировна Долгая, Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176

candidate of medical sciences, docent

Department of Pathology

Анрей Евгениевич Олейник, Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176

candidate of medical sciences,docent

Светлана Владимировна Данилюк, Kharkiv Medical Postgraduate Education st. Korchagintsev, 58, Kharkiv, Ukraine, 61176

candidate of medical sciences, assistent

Department of Pathology

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Published

2015-03-19

Issue

Section

Medical