Inerconnection of the change of vascular-trombocytic hemostasis parameters and sexual hormones level in women with the stable forms of ischemic heart disease in the period of postmenopause
DOI:
https://doi.org/10.15587/2313-8416.2016.59332Keywords:
female sex, thrombocytes aggregation, thrombophilia, hemostasis, postmenopause, ischemic heart diseaseAbstract
Aim: To assess an influence and interconnection of the changed estradiol and progesterone levels with the rates of thrombocytes functional activity on the data of thrombocytes aggregation in women with stable ischemic heart disease.
Materials and methods: There were examined 40 women in the postmenopause with diagnosis the stable angina of I-II functional class. There were studied the estradiol and progesterone levels and interconnection with thrombocytes activity.
Results: The growth of thrombocyte hemostasis activity at rest and in the conditions of using aggregation agonists (arachidonic acid and ADP) was noticed in the groups with low estradiol (<28,42 ng/ml) and progeston (<0,96 ng/ml) level. The hyperactivity of thrombocytes was noticed at induced aggregation of thrombocytes with arachidonic acid, ADP, collagen and adrenalin in women at postmenopause.
Conclusions: The postmenopause period in women with stable forms of IHD is attended with an increase of thrombocyte functional activity at both spontaneous and induced aggregation with the use of all four inductors on the background of the continual receiving of antiplatelet treatmentReferences
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