Content of essential trace elements in the hair of children with short stature due to somatotropic insufficiency
DOI:
https://doi.org/10.15587/2313-8416.2016.67690Keywords:
boys, essential tracer elements, children, hair, short stature, somatotropic insufficiencyAbstract
The content of essential trace elements (zinc, selenium, chrome, magnesium, copper) was studied in 102 children with short stature due to total (n = 66; 54 - boys; mean age 10.23 ± 0.4 years) or partial (n = 36; 26 - boys; mean age 8.91 ± 0.4 years) somatotropic insufficiency.
Aim. The aim of our research was a complex studying the content of essential trace elements (zinc, selenium, manganese, chrome, copper) in the hair of children with low growth, caused by somatotropic insufficiency, to determine the additional ways to optimize the treatment of these patients.
Methods. The content of insulin-like growth factor-1 (IGF-1) was determined once a morning in the blood sample by radioimmunoassay using standard kits «IRMA IGF-1" firm «Immunotech» (Czech Republic). The body height was measured using stadiometer «System Dr. Keller J.», the body mass - using Seca electronic scales. The atlas of W.W. Greulich, S.P. Pyle (1993 was used to determine the bone age.
Results. As a result of our examination a significant decrease in the content of all the studied tracer elements: zinc, selenium, manganese, chrome, copper was noted in the hair of the great majority of children with complete (group I) or partial (group II) somatotropic insufficiency. A sharp decline in zinc content in the hair of patients with complete (78,50 ± 4,31 mcg / g, p˂0.001) and partial (83.94 ± 4.89 mcg / g, p˂0.001) somatotropic insufficiency, compared with reference values and control indices was established. The mean values of selenium, manganese did not differ between themselves and the indices of control group (p˃0.1) in both groups, but they were significantly lower than the reference values. A significant decrease in the chromium content in the hair of girls with the total somatotropic insufficiency comparing to the control group (p˂0.05) was revealed. The tendency to decrease in the content of copper in the hair of boys in the whole group with total somatotropic insufficiency was established.
Conclusions. The obtained data indicate the expediency of studying the tracer elements status in children with short stature due to somatotropic insufficiency and of carrying out the corresponding correction, in a case of essential tracer elements deficiencyReferences
Suliburska, J. (2011). A Comparison of Levels of Select Minerals in Scalp Hair Samples with Estimated Dietary Intakes of These Minerals in Women of Reproductive Age. Biological Trace Element Research, 144 (1-3), 77–85. doi: 10.1007/s12011-011-9034-9
Ozmen, Habibe. The levels of calcium and magnesium, and of selected trace elements, in whole blood and scalp hair of children with growth retardation [Text] / Habibe Ozmen, Saadet Akarsu, Fatih Polat, Alaaddin Cukurovali // Iran J. Pediatr. – 2013. – Vol. 23, N 2. – P. 125–130.
Gude, D. (2011). ′Tracing Elements′ in hair. International Journal of Trichology, 3 (2), 132. doi: 10.4103/0974-7753.90854
Tronko, M. D. Biological role of zinc and the need to ensure an adequate level of its human consumption [Text] / M. D. Tronko, M. O. Polumbryk, V. M. Kovbasa et al. // Bull. Natsional. Academii Nauk Ukrainy. – 2013. – N 6. – P. 21–31.
Kozarenko, B. Zinc deficiency in children [Text] / V. Kozarenko. – LAP LAMBERT Academic Publishing, 2011. – 156 p.
Mayo-Wilson, E. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age [Text] / E. Mayo-Wilson, J. A. Junior, A. Imdad et al. // Cochrane Database of Systematic Reviews. – 2014. – Issue 5. Art. No.: CD009384.
Imdad, A., & Bhutta, Z. A. (2011). Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health, 11(Suppl 3), S22. doi: 10.1186/1471-2458-11-s3-s22
Cabrera-Vique, C., Briones, M., Muros, J. J., Seiquer, I., Sánchez, J. A., Rodríguez, G., & Giménez, R. (2015). A pilot duplicate diet study on manganese, selenium and chromium intakes in institutionalised children and adolescents from Guatemala. Br J Nutr, 114(10), 1604–1611. doi: 10.1017/s0007114515003207
Gluschenko, N. The content of microelements in blood serum and erythrocytes in children with type I diabetes mellitus depending on level of glycemic control [Text] / N. Gluschenko, Kh. Vasylyshyn, A. Roschupkin et al. // Georgian Med. News. – 2016. – N 250. – P. 66–71.
Torabi, Z., Rafiei, R., Habyby, Z., Fouladi, L., Najafi, S., & Asgary, S. (2014). Chromium level in prediction of diabetes in pre-diabetic patients. Advanced Biomedical Research, 3(1), 235. doi: 10.4103/2277-9175.145737
Lewicki, S., Zdanowski, R., Krzyżowska, M., Lewicka, A., Dębski, B., Niemcewicz, M., & Goniewicz, M. (2014). The role of Chromium III in the organism and its possible use in diabetes and obesity treatment. Ann Agric Environ Med, 21(2), 331–335. doi: 10.5604/1232-1966.1108599
Zimmermann, M. B. Thyroid size and goiter prevalence after introduction of iodized salt: a 5–y prospective study in schoolchildren in Cфte d’Ivoire [Text] / M. B. Zimmermann, S. Y. Hess, P. Adou et al. // Am. J. Clin. Nutr. – 2003. – Vol. 77, N 3 – P. 663–667.
Seneff, S., & Samsel, A. (2015). Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int, 6(1), 45. doi: 10.4103/2152-7806.153876
Vakhlova, I. V. Micronutrients for maternal and child health [Text] / I. V. Vahlova // Rossiiskii Pediatricheskii Zhurnal. - 2005. - № 4. - P. 55-59.
Goncharova, N. N. Physical development and functional state of the primary school children with different levels of somatic health [Text] / N. N. Goncharova // Pedagogica, psychologia, e medico-biologicheskie problemi physicheskogo vospitania e sporta. - 2007. - № 5. – P. 57-59.
MacDonald, R. The role of zinc in growth and cell proliferation [Text] / R. MacDonald // J. Nutr. – 2000. – Vol. 130. – P. 1500S–1508S.
Mahmoodi, M. R., & Kimiagar, S. M. (2001). Prevalence of Zinc Deficiency in Junior High School Students of Tehran City. Biological Trace Element Research, 81(2), 093–103. doi: 10.1385/bter:81:2:093
Laitinen, R. (1990). Zinc, copper, and sexual maturation in 9-18-year-old girls and boys. Biological Trace Element Research, 25(1), 71–78. doi: 10.1007/bf02990266
Laitinen, R., Vuori, E., Dahlström, S., & Åkerblom, H. K. (1989). Zinc, Copper, and Growth Status in Children and Adolescents. Pediatric Research, 25(4), 323–326. doi: 10.1203/00006450-198904000-00001
Pediatric endocrinology: A practical clinical guide [Text] / S. Radovick, M. H. MacGillivray (Eds.); Second Edition. – Springer Science + Business Media, LLC, 2013. – 565 p.
Wasantwisut, E. Nutrition and development: other micronutrients' effect on growth and cognition [Text] / E. Wasantwisut // Southeast Asian J. of Trop. Med. Public Health. – 1997. – Vol. 28, Suppl. 2. – P. 78–82.
Nishi, Y. (1996). Zinc and growth. Journal of the American College of Nutrition, 15(4), 340–344. doi: 10.1080/07315724.1996.10718608
Petukhov, V. I. Selenium deficiency in Latvia as a European issue [Text] / V. I. Petukhov // Microelements v meditsini. - 2006. – Vol. 7, N 2. - P. 1-10.
Iyengar, V. Trace elements in human clinical specimens: evaluation of literature data to identify reference values [Text] / V. Iyengar, J. Woittiez // J. Clin. Chem. – 1988. – Vol. 34, N 3. – P. 474–481.
Mikulewicz, M., Chojnacka, K., Gedrange, T., & Górecki, H. (2013). Reference values of elements in human hair: A systematic review. Environmental Toxicology and Pharmacology, 36(3), 1077–1086. doi: 10.1016/j.etap.2013.09.012
Chojnacka, K., Zielińska, A., Michalak, I., & Górecki, H. (2010). The effect of dietary habits on mineral composition of human scalp hair. Environmental Toxicology and Pharmacology, 30(2), 188–194. doi: 10.1016/j.etap.2010.06.002
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