Recurrent pregnancy loss association with allelic variants of IL8 and IL10 genes

Auteurs-es

  • Anastasiia Kucherenko Taras Shevchenko National University of Kyiv Glushkova ave., Kyiv, Ukraine, 03022, Ukraine
  • Roman Gulkovskyi Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680, Ukraine
  • Kseniya Hazhylenko Obstetric – gynecological clinic “ISIDA” 65, Lepse blvd, Kyiv, Ukraine, 03000, Ukraine
  • Iryna Vorobiova SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050, Ukraine
  • Tamara Nakvasiuk SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050, Ukraine
  • Ludmila Livshits Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680, Ukraine

DOI :

https://doi.org/10.15587/2313-8416.2014.27254

Mots-clés :

IL8 gene/ IL10 gene/ interleukin/ recurrent pregnancy loss

Résumé

The study evaluated IL8 -781C/T and IL10 -592C/A, -1082A/G polymorphisms association with recurrent pregnancy loss (RPL) (n=110 case, n=106 control).

IL10 -592АА genotype and -1082A allele carriers frequency was higher in RPL group (6.6 %, 87.3 %) comparing to control (0.9 %, 76.4 %). The -1082A allele carriers have twice increased RPL risk (OR=2.12; CI95 %: 1,03–4,34).

Bibliographies de l'auteur-e

Anastasiia Kucherenko, Taras Shevchenko National University of Kyiv Glushkova ave., Kyiv, Ukraine, 03022

PhD student, junior research fellow

Roman Gulkovskyi, Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680

PhD student, junior research fellow

Department of general and molecular genetics

Kseniya Hazhylenko, Obstetric – gynecological clinic “ISIDA” 65, Lepse blvd, Kyiv, Ukraine, 03000

Obstetrician/gynecologist of Superior Expert Category, geneticist

Iryna Vorobiova, SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050

M.D., obstetrician/gynecologist of Superior Expert Category, Head of the Department

Department of scientific problems of pregnancy loss

Tamara Nakvasiuk, SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050

PhD student

Department of scientific problems of pregnancy loss

Ludmila Livshits, Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680

PhD, Professor, Head of the Department

Human genomics department

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Publié-e

2014-09-16

Numéro

No. 2 (2) (2014)

Rubrique

Biological sciences

Licence

(c) Tous droits réservés Anastasiia Kucherenko, Roman Gulkovskyi, Kseniya Hazhylenko, Iryna Vorobiova, Tamara Nakvasiuk, Ludmila Livshits 2014

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