Recurrent pregnancy loss association with allelic variants of IL8 and IL10 genes

Anastasiia Kucherenko; Roman Gulkovskyi; Kseniya Hazhylenko; Iryna Vorobiova; Tamara Nakvasiuk; Ludmila Livshits

doi:10.15587/2313-8416.2014.27254

Авторы

Anastasiia Kucherenko Taras Shevchenko National University of Kyiv Glushkova ave., Kyiv, Ukraine, 03022, Ukraine
Roman Gulkovskyi Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680, Ukraine
Kseniya Hazhylenko Obstetric – gynecological clinic “ISIDA” 65, Lepse blvd, Kyiv, Ukraine, 03000, Ukraine
Iryna Vorobiova SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050, Ukraine
Tamara Nakvasiuk SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050, Ukraine
Ludmila Livshits Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680, Ukraine

DOI:

https://doi.org/10.15587/2313-8416.2014.27254

Ключевые слова:

IL8 gene/ IL10 gene/ interleukin/ recurrent pregnancy loss

Аннотация

The study evaluated IL8 -781C/T and IL10 -592C/A, -1082A/G polymorphisms association with recurrent pregnancy loss (RPL) (n=110 case, n=106 control).

IL10 -592АА genotype and -1082A allele carriers frequency was higher in RPL group (6.6 %, 87.3 %) comparing to control (0.9 %, 76.4 %). The -1082A allele carriers have twice increased RPL risk (OR=2.12; CI95 %: 1,03–4,34).

Биографии авторов

Anastasiia Kucherenko, Taras Shevchenko National University of Kyiv Glushkova ave., Kyiv, Ukraine, 03022

PhD student, junior research fellow

Roman Gulkovskyi, Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680

PhD student, junior research fellow

Department of general and molecular genetics

Kseniya Hazhylenko, Obstetric – gynecological clinic “ISIDA” 65, Lepse blvd, Kyiv, Ukraine, 03000

Obstetrician/gynecologist of Superior Expert Category, geneticist

Iryna Vorobiova, SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050

M.D., obstetrician/gynecologist of Superior Expert Category, Head of the Department

Department of scientific problems of pregnancy loss

Tamara Nakvasiuk, SI “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine” 8 Maiborody str., Kyiv, Ukraine, 04050

PhD student

Department of scientific problems of pregnancy loss

Ludmila Livshits, Institute of Molecular Biology and Genetics of NAS of Ukraine 150 Zabolotnogo str., Kyiv, Ukraine, 03680

PhD, Professor, Head of the Department

Human genomics department

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