Індуковані діабетом порушення в кірковому шарі нирок щурів: ефект лікування нікотинамідом
DOI :
https://doi.org/10.15587/2313-8416.2015.51241Mots-clés :
кірковий, шар нирок, діабет, нефропатія, нікотинамід, NAD, співвідношення, щури, експеримент, модель, NAD(P)/NAD(P)H париRésumé
Згідно отриманих даних рівень NAD в кірковому шарі нирок був знижений до 0,179±0,012 ммоль/г тканини за діабету проти 0,259±0,023 ммоль/г тканини, Р<0,05 у контролі. Введення нікотинаміду призводило до часткового відновлення рівня NAD у кірковому шарі нирок і співвідношення вільних NAD(P)/ NAD(P)H пар
Références
Yang, H., Jin, X., Kei Lam, C. W., Yan, S.-K. (2011). Oxidative stress and diabetes mellitus. Clinical Chemistry and Laboratory Medicine, 49 (11), 1773–1782. doi: 10.1515/cclm.2011.250
Fiorentino, T., Prioletta, A., Zuo, P., Folli, F. (2013). Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases. Current Pharmaceutical Design, 19 (32), 5695–5703. doi: 10.2174/1381612811319320005
Popov, D. (2010). Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes. International Journal of Diabetes Mellitus, 2 (3), 189–195. doi: 10.1016/j.ijdm.2010.09.002
Dunne, J. L., Overbergh, L., Purcell, A. W., Mathieu, C. (2012). Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure? Diabetes, 61 (8), 1907–1914. doi: 10.2337/db11-1675
Stanеv, O. І., Zaporozhchenko, O. V., Karpov, L. M. et. al (2006). Vpliv rіznih shtamіv spіrulіni na vmіst laktatu, malatu ta pіruvatu v organah shhurіv za cukrovogo dіabetu. Vіsnik Harkіvs'kogo nacіonal'nogo unіversitetu іmenі V. N. Karazіna, 4 (748), 48–53.
Kuchmerovska, T., Shymanskyy, I., Chlopicki, S., Klimenko, A. (2010). 1-Methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders. Neurochemistry International, 56 (2), 221–228. doi: 10.1016/j.neuint.2009.10.004
Kuchmerovs'ka, T. M., Pentek, Ju. T., Donchenko, G. V., Janіc'ka, L. V., Guzik, M. M., Djakun, K. O. (2013). Okisljuval'nij stres u sercі shhurіv za eksperimental'nogo cukrovogo dіabetu: efekt nіkotinamіdu. Dopovіdі NAN, 8, 176–181.
Guzik, M. M., Djakun, K. O., Janіc'ka, L. V., Kuchmerovs'ka, T. M. (2013). Vpiv іngіbіtorіv polі (ADP-ribozo) polіmerazi na dejakі pokazniki oksidativnogo stresu u lejkocitah krovі shhurіv za eksperimental'nogo cukrovogo dіabetu. UBZh, 85 (1), 62–70.
Bjornstad, P., Cherney, D., Maahs, D. M. (2014). Early diabetic nephropathy in type 1 diabetes. Current Opinion in Endocrinology & Diabetes and Obesity, 21 (4), 279–286. doi: 10.1097/med.0000000000000074
Ivanac-Jancovic R., Lovcic V., Magas S., Sklebar D., Kes P. (2015). The novella about diabetic nephropathy. Acta. Clin. Croat., 54 (1), 83–91.
Bergmeyer, H. U. (Ed.) (1963). MethodsofEnzymaticAnalysis. NewYork: Academic Press Inc., 1064.
Drel, V. R., Pacher, P., Stavniichuk, R., Xu, W., Zhang, J., Kuchmerovska, T. M. et. al. (2011). Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. International Journal of Molecular Medicine, 28 (4), 629–635. doi: 10.3892/ijmm.2011.709
Mykuliak, T., Kuchmerovska, T. (2013). Defects of energetic processes under diabetes and its complications. Ukranian Food Journal, 2 (3), 52–56.
Belenky, P., Bogan, K. L., Brenner, C. (2007). NAD+ metabolism in health and disease. Trends in Biochemical Sciences, 32 (1), 12–19. doi: 10.1016/j.tibs.2006.11.006
Kuchmerovska, T., Shymanskyy, I., Donchenko, G., Kuchmerovskyy, M., Pakirbaieva, L., Klimenko, A. (2004). Poly (ADP-ribosyl) ation enhancement in brain cell nuclei is associated with diabetic neuropathy. Journal of Diabetes and Its Complications, 18 (4), 198–204. doi: 10.1016/s1056-8727(03)00039-4
Schreiber, V., Dantzer, F., Ame, J.-C., de Murcia, G. (2006). Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol, 7 (7), 517–528. doi: 10.1038/nrm1963
Starkov, A. A., Fiskum, G., Chinopoulos, C. et. al (2004). Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species. Journal of Neuroscience, 24 (36), 7779–7788. doi: 10.1523/jneurosci.1899-04.2004
Alano, C. C., Ying, W., Swanson, R. A. (2004). Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition. Journal of Biological Chemistry, 279 (18), 18895–18902. doi: 10.1074/jbc.m313329200
Xia, W., Wang, Z., Wang, Q., Han, J., Zhao, C., Hong, Y. et. al (2009). Roles of NAD/NADH and NADP+/NADPH in Cell Death. Current Pharmaceutical Design, 15 (1), 12–19. doi: 10.2174/138161209787185832
Lanaspa, M. A., Ishimoto, T., Cicerchi, C., Tamura, Y., Roncal-Jimenez, C. A., Chen, W. et. al. (2014). Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy. Journal of the American Society of Nephrology, 25 (11), 2526–2538. doi: 10.1681/asn.2013080901
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