Індуковані діабетом порушення в кірковому шарі нирок щурів: ефект лікування нікотинамідом
DOI:
https://doi.org/10.15587/2313-8416.2015.51241Słowa kluczowe:
кірковий, шар нирок, діабет, нефропатія, нікотинамід, NAD, співвідношення, щури, експеримент, модель, NAD(P)/NAD(P)H париAbstrakt
Згідно отриманих даних рівень NAD в кірковому шарі нирок був знижений до 0,179±0,012 ммоль/г тканини за діабету проти 0,259±0,023 ммоль/г тканини, Р<0,05 у контролі. Введення нікотинаміду призводило до часткового відновлення рівня NAD у кірковому шарі нирок і співвідношення вільних NAD(P)/ NAD(P)H пар
Bibliografia
Yang, H., Jin, X., Kei Lam, C. W., Yan, S.-K. (2011). Oxidative stress and diabetes mellitus. Clinical Chemistry and Laboratory Medicine, 49 (11), 1773–1782. doi: 10.1515/cclm.2011.250
Fiorentino, T., Prioletta, A., Zuo, P., Folli, F. (2013). Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases. Current Pharmaceutical Design, 19 (32), 5695–5703. doi: 10.2174/1381612811319320005
Popov, D. (2010). Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes. International Journal of Diabetes Mellitus, 2 (3), 189–195. doi: 10.1016/j.ijdm.2010.09.002
Dunne, J. L., Overbergh, L., Purcell, A. W., Mathieu, C. (2012). Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure? Diabetes, 61 (8), 1907–1914. doi: 10.2337/db11-1675
Stanеv, O. І., Zaporozhchenko, O. V., Karpov, L. M. et. al (2006). Vpliv rіznih shtamіv spіrulіni na vmіst laktatu, malatu ta pіruvatu v organah shhurіv za cukrovogo dіabetu. Vіsnik Harkіvs'kogo nacіonal'nogo unіversitetu іmenі V. N. Karazіna, 4 (748), 48–53.
Kuchmerovska, T., Shymanskyy, I., Chlopicki, S., Klimenko, A. (2010). 1-Methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders. Neurochemistry International, 56 (2), 221–228. doi: 10.1016/j.neuint.2009.10.004
Kuchmerovs'ka, T. M., Pentek, Ju. T., Donchenko, G. V., Janіc'ka, L. V., Guzik, M. M., Djakun, K. O. (2013). Okisljuval'nij stres u sercі shhurіv za eksperimental'nogo cukrovogo dіabetu: efekt nіkotinamіdu. Dopovіdі NAN, 8, 176–181.
Guzik, M. M., Djakun, K. O., Janіc'ka, L. V., Kuchmerovs'ka, T. M. (2013). Vpiv іngіbіtorіv polі (ADP-ribozo) polіmerazi na dejakі pokazniki oksidativnogo stresu u lejkocitah krovі shhurіv za eksperimental'nogo cukrovogo dіabetu. UBZh, 85 (1), 62–70.
Bjornstad, P., Cherney, D., Maahs, D. M. (2014). Early diabetic nephropathy in type 1 diabetes. Current Opinion in Endocrinology & Diabetes and Obesity, 21 (4), 279–286. doi: 10.1097/med.0000000000000074
Ivanac-Jancovic R., Lovcic V., Magas S., Sklebar D., Kes P. (2015). The novella about diabetic nephropathy. Acta. Clin. Croat., 54 (1), 83–91.
Bergmeyer, H. U. (Ed.) (1963). MethodsofEnzymaticAnalysis. NewYork: Academic Press Inc., 1064.
Drel, V. R., Pacher, P., Stavniichuk, R., Xu, W., Zhang, J., Kuchmerovska, T. M. et. al. (2011). Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. International Journal of Molecular Medicine, 28 (4), 629–635. doi: 10.3892/ijmm.2011.709
Mykuliak, T., Kuchmerovska, T. (2013). Defects of energetic processes under diabetes and its complications. Ukranian Food Journal, 2 (3), 52–56.
Belenky, P., Bogan, K. L., Brenner, C. (2007). NAD+ metabolism in health and disease. Trends in Biochemical Sciences, 32 (1), 12–19. doi: 10.1016/j.tibs.2006.11.006
Kuchmerovska, T., Shymanskyy, I., Donchenko, G., Kuchmerovskyy, M., Pakirbaieva, L., Klimenko, A. (2004). Poly (ADP-ribosyl) ation enhancement in brain cell nuclei is associated with diabetic neuropathy. Journal of Diabetes and Its Complications, 18 (4), 198–204. doi: 10.1016/s1056-8727(03)00039-4
Schreiber, V., Dantzer, F., Ame, J.-C., de Murcia, G. (2006). Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol, 7 (7), 517–528. doi: 10.1038/nrm1963
Starkov, A. A., Fiskum, G., Chinopoulos, C. et. al (2004). Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species. Journal of Neuroscience, 24 (36), 7779–7788. doi: 10.1523/jneurosci.1899-04.2004
Alano, C. C., Ying, W., Swanson, R. A. (2004). Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition. Journal of Biological Chemistry, 279 (18), 18895–18902. doi: 10.1074/jbc.m313329200
Xia, W., Wang, Z., Wang, Q., Han, J., Zhao, C., Hong, Y. et. al (2009). Roles of NAD/NADH and NADP+/NADPH in Cell Death. Current Pharmaceutical Design, 15 (1), 12–19. doi: 10.2174/138161209787185832
Lanaspa, M. A., Ishimoto, T., Cicerchi, C., Tamura, Y., Roncal-Jimenez, C. A., Chen, W. et. al. (2014). Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy. Journal of the American Society of Nephrology, 25 (11), 2526–2538. doi: 10.1681/asn.2013080901
##submission.downloads##
Opublikowane
Numer
Dział
Licencja
Copyright (c) 2015 Леся Василівна Яніцька
Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa 4.0 Międzynarodowe.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
