Методи ідентифікації та кількісного визначення Β-адреноблокаторів (огляд літератури)

Auteurs-es

  • Ольга Олександрівна Віслоус Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Ukraine
  • Наталія Юріївна Бевз Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Ukraine
  • Вікторія Акопівна Георгіянц Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Ukraine

DOI :

https://doi.org/10.15587/2313-8416.2015.52357

Mots-clés :

артеріальна гіпертензія, фармацевтичний аналіз, β-адреноблокатори, спектрофотометрія, хроматографія, субстанція, лікарські форми

Résumé

Кількість β-адреноблокаторів на фармацевтичному ринку з кожним роком збільшується, що потребує систематизації методик їх стандартизації.

Мета. Метою наших досліджень є вивчення літературних даних щодо методик ідентифікації та кількісного визначення β-адреноблокаторів різної направленості дії – селективної (практолол, метопролол, атенолол, ацебутолол, бетаксолол, бевантолол, бісопролол, целіпролол, есмолол, епанолол, есатенолол, небіволол, талінолол), неселективної (алпренолол, окспренолол, піндолол, пропранолол, тимолол, соталол, надолол, мепіндолол, картеол, тертатолол, бопіндолол, бупранолол, пенбутолол, клоранолол) та комбінованої (лабеталол, карведілол).

Методи. Аналітичний огляд літературних джерел інформації щодо дослідження β-адреноблокаторів фізичними, хімічним та фізико-хімічним методами аналізу.

Результати. У результаті аналізу літературних джерел встановлено, що для ідентифікації БАБ у фармакопейному аналізі в основному застосовують фізичні та фізико-хімічні константи, у судовому аналізі – як фізико-хімічні величини, так і хімічні реакції, результати яких наведені в роботі.

Встановлено, що для кількісної оцінки БАБ в аналізі субстанцій використовують титриметричні методи, найчастіше метод кислотно-основного титрування. Для виявлення β-адреноблокаторів у біологічних рідинах та лікарських формах, розділення суміші активних фармацевтичних інгредієнтів та метаболітів перевагу слід віддати фізико-хімічним методам, таким як газорідинна і рідинна хроматографія, абсорбційна спектрофотометрія в ультрафіолетовій та видимій областях, флюорометрія та інш.

Висновки. Приведені дані можуть бути застосовані для подальшого пошуку оптимальних методик ідентифікації та кількісного визначення β-адреноблокаторів як чистому вигляді, так і в суміші з іншими діючими та допоміжними речовинами

Bibliographies de l'auteur-e

Ольга Олександрівна Віслоус, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Здобувач

Кафедра фармацевтичної хімії 

Наталія Юріївна Бевз, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Кандидат фармацевтичних наук, доцент

Кафедра фармацевтичної хімії 

Вікторія Акопівна Георгіянц, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Доктор фармацевтичних наук, професор

Кафедра фармацевтичної хімії 

Références

Belovol, A. N. (2012). Klinicheskaja farmakologija beta-blokatorov, primenjaemyh pri hronicheskoj serdechnoj nedostatochnosti. Svіt medicini ta bіologіi, 1, 7–13.

Radchenko, O. M. (2009). Beta-adrenoblokatori u lіkuvannі sercevoi nedostatnostі. Medichna gіdrologіja ta reabіlіtacіja, 7 (1), 11–19.

Belikov, V. G. (2002). Analiz lekarstvennyh veshhestv fotometricheskimi metodami. Opyt raboty otechestvennyh specialistov. Ros. him. zh. (Zh. Ros. him. ob-va im. D. I. Mendeleeva), XLVI (4), 52–56.

Derzhavna Farmakopeja Ukrainy (2001). Derzhavne pіdpriemstvo “Naukovo-ekspertnij farmakopejnij centr”. Kharkіv, 978 .

Derzhavna Farmakopeja Ukrainy (2008). Derzh. p-vo «Naukovo-ekspertnij farmakopejnij centr». Kharkiv: RІREG, 620.

British Pharmacopoeia. Vol. I-II (2009).

European Pharmacopoeia (2009).

United States Pharmacopoeia (2009).

Japanese Pharmacopoeia Sixteenth Edition (2011). 2131.

Canotilho, J., Castro, R. A. E. (2010). The structure of betaxolol studied by infrared spectroscopy and natural bond orbital theory. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 76 (3-4), 395–400. doi: 10.1016/j.saa.2010.03.038

Demme, U. et. al (2005). Systematic evaluation of 1-chlorobutane for liquid–liquid extraction of drugs. Proceedings of the 12th TIAFT, Seoul, 481–486.

Kwiecień, A., Krzek, J., Zylewski, M. (2008). Stability of chosen beta-adrenolytic drugs of different polarity in basic environment. J AOAC Int., 91 (2), 322–331.

Novákné, P. M. (1990). Bromatometric determination of oxprenolol. Acta pharmaceutica Hungarica, 60 (4), 162–164.

Vaikosen, E. N., Ebeshi, B. U., Joffa, P. P. K. (2012). Simple, Sensitive and Reproducible Acetous Perchlorate and Spectrophotometric Determination of Atenolol in Tablet Dosage Form. J. Pharm. Sci. & Res.,4 (10), 1933–1938. Available at: http://www.jpsr.pharmainfo.in/Documents/Volumes/vol4issue10/jpsr%2004121001.pdf

Marko, V. (Ed.) (1989). Evalutation of analytical methods in biological systems. Part C. Determination of Beta-Blockers in Biological Material. Vol. 4. Techniques and instrumentation in analytical chemistry. Amsterdam – London – New York, 320.

Ganesan, M., Nanjundan, S., Rauthan, K. S., Eswaran, K., Tripathi, P. (2010). Rapid analysis of labetalol in human plasma using liquid chromatography-tandem mass spectrometry. International Journal of Pharmaceutical Sciences and Research, 1 (12), 209–218. Available at: http://www.researchgate.net/publication/228085245_RAPID_ANALYSIS_OF_LABETALOL_IN_HUMAN_PLASMA_USING_LIQUID_CHROMATOGRAPHY-TANDEM_MASS_SPECTROMETRY

Krzek, J., Kwiecień, A. (2005). Application of densitometry for determination of beta-adrenergic-blocking agents in pharmaceutical preparations. Journal of Planar Chromatography – Modern TLC, 18 (104), 308–313. doi: 10.1556/jpc.18.2005.4.11

Bendapudi, P., Venketeswara, R. P., Sudhakar babu, A. M. S., Pramo, N. (2012). Development of rp-hplc method for the simultaneous estimation of propranolol hydrochloride and hydrochlorothiazide in combined dosage form. International Journal of Biological & Pharmaceutical Research, 3 (7), 899–903. Available at: http://www.ijbpr.com/cadmin/article/243_ijbpr%202012%203(7)899-903.pdf

Chitlange, S., Imran, M., Sakarkar, D. (2008). RP-HPLC method for simultaneous estimation of amlodipine and metoprolol in tablet formulation. Asian Journal of Pharmaceutics, 2 (4), 232. doi: 10.4103/0973-8398.45037

Aqil, M., Sultana, Y., Ali, A., Imam, S., Ahad, A. (2013). A validated RP-HPLC method for simultaneous determination of propranolol and valsartan in bulk drug and gel formulation. Journal of Pharmacy and Bioallied Sciences, 5 (1), 61. doi: 10.4103/0975-7406.106573

Tulja, R. G., Gowri, S. D., Kadgapathi, P., Satyanarayana, B. (2011). A validated RP HPLC method for simultaneous determination of propranolol hydrochloride and alprazolam in bulk and in pharmaceutical formulations. Journal of Pharmacy Research, 4, 358–360.

Zhang, J., Ding, L., Wen, A., Wu, F., Sun, L., Yang, L. (2009). An HPLC ESI-MS method for the determination of propranolol in human plasma and its application to pharmacokinetic studies. Asian Journal of Pharmaceutical Sciences, 4 (3), 169–177.

Sarafraz-yazdi, A., Abedi, M. R., Es’haghi, Z., Fadaee-Kakhki, J. (2012). Simultaneous determination of metoprolol and propranolol using chemometric-assisted spectrophotometry and high-performance liquid chromatography. International Journal of Pharma and Bio Sciences, 3 (3), 532–542. Available at: http://www.ijpbs.net/vol-3/issue-3/pharma/58.pdf

Zarapkar, S. S., Kolte, S. S., Rane, S. H. (1997). High performance liquid chromatographic determination of amlodipine and atenolol, simultaneously from pharmaceutical preparation. Indian Drugs, 34 (6), 350–353.

Modamio, P., Lastra, C., Mariño, E. (1998). Error structure for the HPLC analysis for atenolol, metoprolol and propranolol: a useful weighting method in parameter estimation. Journal of Pharmaceutical and Biomedical Analysis, 17 (3), 507–513. doi: 10.1016/s0731-7085(97)00236-7

Santoro, M. I. R. M., Cho, H. S., Kedor-Hackmann, E. R. M. (2000). Enantiomeric Separation and Quantitative Determination of Atenolol in Tablets by Chiral High-Performance Liquid Chromatography. Drug Development and Industrial Pharmacy, 26 (10), 1107–1110. doi: 10.1081/ddc-100100275

Ceresole, R., Moyano, M. A., Pizzorno, M. T., Segall, A. I. (2006). Validated Reversed‐Phase HPLC Method for the Determination of Atenolol in the Presence of Its Major Degradation Product. Journal of Liquid Chromatography & Related Technologies, 29 (20), 3009–3019. doi: 10.1080/10826070600983393

Bing, L., Hu, D. F., Liu, F. (2004). HPLC determination of atenolol and nifedipine in compound atenolol tablets. Yaowu Fenxi Zazhi, 24 (5), 485–486.

Singh, A. K., Kedor-Hackmann, E. R. M., Santoro, M. I. R. M. (2001). Development and validation of a chiral liquid chromatographic method for the determination of atenolol and metoprolol enantiomers in tablet preparations. Journal of AOAC International, 84 (6), 1724–1729.

Bhushan, R., Tanwar, S. (2009). Reversed-phase high-performance liquid chromatographic enantioresolution of six β-blockers using dinitrophenyl-l-Pro-N-hydroxysuccinimide ester, N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate and twelve variants of Sanger's reagent as chiral derivatizing reagents. Biomedical Chromatography, 23 (12), 1291–1299. doi: 10.1002/bmc.1252

El Deeb, S. (2010). Evaluation of a Vancomycin-Based LC Column in Enantiomeric Separation of Atenolol: Method Development, Repeatability Study and Enantiomeric Impurity Determination. Chromatographia, 71 (9-10), 783–787. doi: 10.1365/s10337-010-1548-3

Ceniceros, C., Maguregui, M., Jiménez, R., Alonso, R. (1998). Quantitative determination of the β-blocker labetalol in pharmaceuticals and human urine by high-performance liquid chromatography with amperometric detection. Journal of Chromatography B: Biomedical Sciences and Applications, 705 (1), 97–103. doi: 10.1016/s0378-4347(97)00492-1

Delamoye, M., Duverneuil, C., Paraire, F., Mazancourt, P. de, Alvarez, J.-C. (2004). Simultaneous determination of thirteen β-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection. Forensic Science International, 141 (1), 23–31. doi: 10.1016/j.forsciint.2003.12.008

Saleem, K., Ali, I., Kulsum, U., Aboul-Enein, H. Y. (2013). Recent Developments in HPLC Analysis of β-Blockers in Biological Samples. Journal of Chromatographic Science, 51 (8), 807–818. doi: 10.1093/chromsci/bmt030

Shahlaeia, M., Hassanzadehb, F., Emamic, J., Sohrabib, E., Saghaie, L. (2013). Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison with HPLC. Journal of Reports in Pharmaceutical Sciences, 2 (2), 179–189.

Ali, I., Kulsum, U., Saleem, K., Nagae, N., Gaitonde, V. D. (2015). Novel SPE-HPLC Method for Analyses of β- Blockers in Human Plasma Using New Generation Phenyl-Ethyl Column. American Journal of Advanced Drug Delivery, 3 (1), 032–051. Available at: http://www.ojadd.com/index.php/AJADD/article/view/137/137

Hyotylainen, T., Andersson, T., Riekkola, M.-L. (1997). Liquid Chromatographic Sample Cleanup Coupled On-Line with Gas Chromatography in the Analysis of Beta-Blockers in Human Serum and Urine. Journal of Chromatographic Science, 35 (6), 280–286. doi: 10.1093/chromsci/35.6.280

Angier, M. K., Lewis, R. J., Chaturvedi, A. K., Canfield, D. V. (2005). Gas Chromatographic-Mass Spectrometric Differentiation of Atenolol, Metoprolol, Propranolol, and an Interfering Metabolite Product of Metoprolol. Journal of Analytical Toxicology, 29 (6), 517–521. doi: 10.1093/jat/29.6.517

Sadana, G. S., Ghogare, A. B. (1990). Quantitative gas liquid chromatographic determination of atenolol in bulk drug and pharmaceutical preparations. Indian Drugs, 28 (3), 142–145.

Ghanem, R., Bello, M. A., Callejón, M., Guiratúm, A. (1996). Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography. Journal of Pharmaceutical and Biomedical Analysis, 15 (3), 383–388. doi: 10.1016/s0731-7085(96)01864-x

Weich, A., de Oliveira, D. C., de Melo, J., Goebel, K., Rolim, C. M. B. (2007). Validation of UV Spectrophotometric and HPLC Methods for Quantitative Determination of Atenolol in Pharmaceutical Preparations. Lat. Am. J. Pharm., 26 (5), 765–70. Available at: http://www.latamjpharm.org/trabajos/26/5/LAJOP_26_5_3_4_2HR4DR455R.pdf

Delamoye, M., Duverneuil, C., Paraire, F., Mazancourt, P. de, Alvarez, J.-C. (2004). Simultaneous determination of thirteen β-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection. Forensic Science International, 141 (1), 23–31. doi: 10.1016/j.forsciint.2003.12.008

Tracqui, A., Kintz, P., Himber, J., Lugnier, A. A. J., Mangin, P. (1988). A specific HPLC method for determination of β-blockers topically used in ophthalmological diseases. Forensic Science International, 38 (1-2), 37–41. doi: 10.1016/0379-0738(88)90007-2

Ivanova, T. V., Shvachko, E. B., Rumjanceva, D. O., Belolipeckaja, V. G. et. al (1994). Sravnitel'nyj analiz jenantiomerov propranolola v syvorotke krovi s ispol'zovaniem tverdofaznoj jekstrakcii. Zhurn. fiz. Himii, 68 (10), 1806–1808.

Pavlikov, S. A., Belolipeckaja, V. G., Piotrovskij, V. K. (1990). Ispol'zovanie tverdofaznoj jekstrakcii dlja opredelenija propranolola i ego metabolitov metodom VJeZhH. Himiko-farmacevticheskij zhurnal, 24 (2), 174–176.

Posluszny, J. V., Wenberger, R., Woolf, E. (1990). Optimization of multidimensional high-performance liquid chromatography for the determination of drugs in plasma by direct injection, micellar cleanup and photodiode array detection. Journal of Chromatography A, 507, 267–276. doi: 10.1016/s0021-9673(01)84204-7

Yamashita, K., Motohashi, M., Yashiki, T. (1990). Sensitive high-performance liquid chromatographic determination of propranolol in human plasma with ultraviolet detection using column switching combined with ion-pair chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 527, 196–200. doi: 10.1016/s0378-4347(00)82100-3

Szumito, H., Przyborowska, M. (1989). Oznaczanie niektorych lekow -adrenolitycznych metoda wysokosprawnej chromatogratii cieczowej. Farmpol., 45 (5), 304–307.

Gneushev, E. T., Mamedov, T. Sh., Gneusheva, I. A. et. al (1991). Svjaz' propranolola s belkami plazmy i jeritrocitami. Farmakologija i toksikologija, 54 (1), 55–57.

Vázquez, P. P., Galera, M. M., Guirado, A. S., Vázquez, M. M. P. (2010). Determination of five beta-blockers in wastewaters by coupled-column liquid chromatography and fluorescence detection. Analytica Chimica Acta, 666 (1-2), 38–44. doi: 10.1016/j.aca.2010.03.049

Rejhart, D. V., Chistjakov, V. V. (2010). Analiz lekarstvennyh sredstv pri farmakokineticheskih isledovanijah. Kazanskij medicinskij zhurnal, 91 (4), 532–536.

Zhdanov, Ju. A., Kolesnikov, E. I., Arzamascev, A. P. et. al (1983). Kolichestvennyj analiz propranolola v plazme krovi metodom GZhH. Him.-farmac. zhurn., XVII (10), 1269–1271.

YamaguchI, T., Murase, H., Mori, I., Fujita, Y. (2001). Spectrophotometric determination of propranolol hydrochloride and its related drugs based on color development with the Bromopyrogallol Red-molybdenum (VI) complex. Bunseki Kagaku, 50 (8), 563–566. doi: 10.2116/bunsekikagaku.50.563

Pyramides, G., Robinson, J. W., William Zito, S. (1995). The combined use of DSC and TGA for the thermal analysis of atenolol tablets. Journal of Pharmaceutical and Biomedical Analysis, 13 (2), 103–110. doi: 10.1016/0731-7085(94)00112-f

Coragem Briguenti, A. C., Bonato, P. S. (2005). Quantitative Analysis of β-Blockers inPharmaceutical Preparations by Capillary Electrophoresis. Drug Development and Industrial Pharmacy, 31 (2), 209–214. doi: 10.1081/ddc-200047809

Al Azzam, K., Elbashir, A. A., Elbashir, M. A., Saad, B., Abdul Hamid, S. (2009). Simultaneous Determination of Atenolol and Chlorthalidone in Pharmaceutical Preparations by Capillary-Zone Electrophoresis. Analytical Letters, 42 (10), 1458–1470. doi: 10.1080/00032710902961065

Shafaati, A., Clark, B. J. (1996). Development and validation of a capillary zone electrophoretic method for the determination of atenolol in presence of its related substances in bulk and tablet dosage form. Journal of Pharmaceutical and Biomedical Analysis, 14 (11), 1547–1554. doi: 10.1016/0731-7085(96)01772-4

Kartamyshev, S. V., Rjasenskij, S. S., Gorelov, I. P. (2002). Jelektrody, selektivnye k kationnoj forme propranolola, i ih ispol'zovanie v farmacevticheskom analize. Him.-farmac. zhurn., 5, 50–51.

El-Ries, M., Abou-Sekkina, M., Wassel, A. (2002). Polarographic determination of propranolol in pharmaceutical formulation. Journal of Pharmaceutical and Biomedical Analysis, 30 (3), 837–842. doi: 10.1016/s0731-7085(02)00087-0

Ghoneim, M. M., Abdel-Azzem, M. K., El-Desoky, H. S., Ghoneim, A. M., Khattab, A. E. (2014). Electrochemical reduction and stripping voltammetric determination of the anti-glaucoma drug levobunolol HCl in formulation and human serum at the mercury electrode. Journal of the Brazilian Chemical Society, 25 (8), 1407–1418. doi: 10.5935/0103-5053.20140123

Al-Ghamdi, A. F., Hefnawy, M. M., Al-Majed, A. A., Belal, F. F. (2012). Development of square-wave adsorptive stripping voltammetric method for determination of acebutolol in pharmaceutical formulations and biological fluids. Chemistry Central Journal, 6 (1), 15. doi: 10.1186/1752-153x-6-15

Bozal, B., Gumustas, M., -Topal, B. D., Uslu, B., Ozkan, S. A. (2013). Fully Validated Simultaneous Determination of Bisoprolol Fumarate and Hydrochlorothiazide in Their Dosage Forms Using Different Voltammetric, Chromatographic, and Spectrophotometric Analytical Methods. Journal of AOAC International, 96 (1), 42–51. doi: 10.5740/jaoacint.11-364

Goyal, R., Singh, S. (2006). Voltammetric determination of atenolol at C60-modified glassy carbon electrodes. Talanta, 69 (4), 932–937. doi: 10.1016/j.talanta.2005.11.041

Eller, T. D., Knapp, D. R. (1986). Aminoalkoxy or carboxyalkoxy derivatives of propranolol for immuno-assay applications: Pat. 4795715 USA, MKI4 G Ol N 33/53. № 901772, Zajavl. 03.10.86; Opubl. 03.01.89; NKI 436/542.

Poljudek-Fabini, R., Bejrih, T. (1981). Organicheskij analiz. Leningrad: Himija, 622.

Dhiraj, K., Alka, A., Khar, R. K. (1990). Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride. Pharmazie, 45 (5), 256–258.

Segi, N., Yotsuyanagi, T., Ikeda, K. (1989). Interaction of calcium-induced alginate gel beads with propranolol. CHEMICAL & PHARMACEUTICAL BULLETIN, 37 (11), 3092–3095. doi: 10.1248/cpb.37.3092

Patil, S. M., Panchal, V. S., Chilkawar, R. N. (2013). Development of validated uv spectrophotometric method for estimation of betaxolol hydrochloride in bulk and pharmaceutical dosage form. International Journal of Pharmaceutical Research and Bio-science, 2 (5), 404–413.

Mohammedi, H., S. Shyale, S., Kumar, M. S. (2011). Physico-chemical characterization, uv spectrophotometric method development and validation studies of timolol maleate. International Journal of Pharmaceutical Sciences Review and Research, 6 (2), 163–166. Available at: http://globalresearchonline.net/journalcontents/volume6issue2/Article-030.pdf

Abdelwahab, N. S. (2011). Spectrophotometric methods for simultaneous determination of Carvedilol and Hydrochlorothiazide in combined dosage form. Arabian Journal of Chemistry. doi: 10.1016/j.arabjc.2011.05.002

Elzanfaly, E. S., Saad, A. S., Abd Elaleem, A. E. B. (2012). A smart simple spectrophotometric method for simultaneous determination of binary mixtures. Journal of Pharmaceutical Analysis, 2 (5), 382–385. doi: 10.1016/j.jpha.2012.04.004

Lotfy, H. M., Hegazy, M. A., Rezk, M. R., Omran, Y. R. (2014). Novel spectrophotometric methods for simultaneous determination of timolol and dorzolamide in their binary mixture. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 126, 197–207. doi: 10.1016/j.saa.2014.02.005

Shah, P. A., Kadikar, A. S., Katira, R. M. et. al (2014). Simultaneous determination of brinzolamide and timolol maleate using three different spectrophotometric methods. World Journal of Pharmacy and Pharmaceutical Sciences, 3 (2), 1955–1967.

Dey, S., Sarkar, S., Malakar, J. et. al (2012). Spectrophotometric method for simultaneous determination of atenolol and atorvastatin in tablet dosage forms. Int J Pharm Biomed Res., 3 (1), 40–43. Available at: http://www.pharmscidirect.com/Docs/IJPBR-2012-01-91.pdf

Theivarasu, C., Ghosh, S., Indumathi, T. (2010). UV Spectrophotometric determinationof carvedilol in pharmaceutical formulations. Asian Journal of Pharmaceutical and Clinical Research, 3 (4), 64–68. Available at: http://www.ajpcr.com/Vol3Issue4/122.pdf

Desai, D. C., Karkhanis, V. V. (2012). Simple spectrophotometric estimation of carvedilol phosphate in bulk and tablet dosage forms. International Research Journal of Pharmacy, 3 (2), 114–116. Available at: http://www.irjponline.com/admin/php/uploads/851_pdf.pdf

Yu, L. L., Liu, J. C., Li, H. K. (2010). Spectrophotometry determination of atenolol in tablets based on charge transfer complex of atenolol with chloranilic acid. Yaowu Fenxi Zazhi, 30 (3), 538–540.

Agarwal, S. P., Singhal, V, Prakash, A. (1998). Spectrophotometric determination of atenolol and timolol dosage forms via charge-transfer complexation. Indian Journal of Pharmaceutical Sciences, 60 (1), 53–55.

Agrawal, Y. K., Raman, K., Rajput, S., Menon, S. K. (1992). Spectrophotometry Determination of Atenolol via Hydroxamic acid Formation. Analytical Letters, 25 (8), 1503–1510. doi: 10.1080/00032719208017132

Ulu, S. T., Kel, E. (2012). Spectrophotometric determination of bisoprolol in pharmaceutical preparations by charge transfer reactions. Optics and Spectroscopy, 112 (6), 864–867. doi: 10.1134/s0030400x12060197

Lakshmi, A. V. (2013). Spectrophotometric Method For Estimation Of Levobunolol In Bulk And Tablet Dosage Form. International Journal of ChemTech Research, 5 (4), 1777–1781. Available at: http://www.sphinxsai.com/2013/VOL5_NO.4_APRIL/PDFS_VOL5_NO.4/CT=50(1777-1781)AJ13.pdf

Prashanth, K. N., Basavaiah, K. (2012). Simple, Sensitive And Selective Spectrophotometric Methods For The Determination Of Atenolol In Pharmaceuticals Through Charge Transfer Complex Formation Reaction. Acta Poloniae Pharmaceutica and Drug Research, 69 (2), 213–223. Available at: http://www.ptfarm.pl/pub/File/Acta_Poloniae/2012/2/213.pdf

Coragem Briguenti, A. C., Bonato, P. S. (2005). Quantitative Analysis of β-Blockers inPharmaceutical Preparations by Capillary Electrophoresis. Drug Development and Industrial Pharmacy, 31 (2), 209–214. doi: 10.1081/ddc-200047809

Shehata, M. A., El-Sayed, G. M., Abdel-Fattah, L. E. (2006). Utilization of 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) for kinetic spectrophotometric assay of befunolol hydrochloride in its pharmaceutical formulation. J AOAC Int.,89 (3), 646–50.

Al-Ghannam, S. M., Belal, F. (2002). Kinetic spectrophotometric determination of atenolol in dosage forms. JAOAC Int., 85 (4), 817–23.

Shetty, D. N., Narayana, B. (2012). Simple Methods for the Spectrophotometric Determination of Carvedilol. ISRN Spectroscopy, 2012, 1–6. doi: 10.5402/2012/373215

Cesme, M., Tarinc, D., Golcu, A. (2011). Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II). Pharmaceuticals, 4 (12), 964–975. doi: 10.3390/ph4070964

Panainte, A. D., Bibire, N., Apostu, G., Vieriu, M. M. (2013). Validation of a spectrophotometric assay method for bisoprolol using picric acid. Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧I., 117 (2), 520–524.

Prashanth, K. N., Basavaiah, K. (2012). Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent. Journal of Analytical Methods in Chemistry, 2012, 1–12. doi: 10.1155/2012/810156

Basavaiah, K., Chandrashekar, U., Nagegowda, P. (2006). Titrimetric, spectrophotometric and kinetic methods for the assay of atenolol using bromate-bromide and methyl orange. Journal of the Serbian Chemical Society, 71 (5), 553–563. doi: 10.2298/jsc0605553b

Basavaiah, K., Chandrashekar, U., Somashekar, B. C., Ramakrishna, V. (2005). Development and validation of neutralization reaction based on analytical methods for the assay of atenolol in pharmaceuticals. Proceedings of the National Academy of Sciences of India A, 75 (4), 233–238.

Basavaiah, K., Chandrashekar, U., Nagegowda, P. (2004). Sensitive determination of atenolol in tablets using chloramine-T and two dyes. Indian Journal of Chemical Technology, 11 (6), 769–776. Available at: http://nopr.niscair.res.in/bitstream/123456789/9548/1/IJCT%2011(6)%20769-776.pdf

Basavaiah, K., Chandrashekar, U., Prameela, H., Nagegowda, P. (2003). Quantitative determination of propranolol with bromate and methyl orange. Acta Ciencia Indica, Chemistry, 29, 25–30.

Suhagia, B., Shah, S., Rathod, I., Patel, H., Dave, H. (2006). Spectrophotometric estimation of Betaxolol Hydrochloride in bulk powder and its dosage forms. Indian Journal of Pharmaceutical Sciences, 68 (2), 267. doi: 10.4103/0250-474x.25735

Hiremath, G. C., Mulla, R. M., Nandibewoor, S. T. (2005). Kinetic methods of determination of atenolol in pure compound and in pharmaceutical formulations. Chemia Analityczna, 50 (2), 449–455.

Cardoso, S. G., Ieggli, C. V., Pomblum, S. C. (2007). Spectrophotometric determination of carvedilol in pharmaceutical formulations through charge-transfer and ion-pair complexation reactions. Pharmazie, 62 (1), 34–37.

El-Emam, A. A., Belal, F. F., Moustafa, M. A., El-Ashry, S. M., El-Sherbiny, D. T., Hansen, S. H. (2003). Spectrophotometric determination of propranolol in formulations via oxidative coupling with 3-methylbenzothiazoline-2-one hydrazone. Il Farmaco, 58 (11), 1179–1186. doi: 10.1016/s0014-827x(03)00199-x

Prashanth, K. N., Basavaiah, K. (2014). Quantitative Spectrophotometric Determination of Propranolol Hydrochloride in Pharmaceuticals Using Cerium(IV) Sulphate as Oxidimetric Reagent. Proceedings of the National Academy of Sciences, India Section A: Physical Sciences, 84 (1), 27–35. doi: 10.1007/s40010-013-0106-4

Madhusudana Reddy, T., Jayarama Reddy, S. (2004). Differential Pulse Adsorptive Stripping Voltammetric Determination of Nifedipine and Nimodipine in Pharmaceutical Formulations, Urine, and Serum Samples by Using a Clay‐Modified Carbon‐Paste Electrode. Analytical Letters, 37 (10), 2079–2098. doi: 10.1081/al-200026681

Al-Ghannam, S. M. (2006). A simple spectrophotometric method for the determination of β-blockers in dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 40 (1), 151–156. doi: 10.1016/j.jpba.2001.12.001

Ghoneim, M. M., Abdel-Azzem, M. K., El-Desoky, H. S., Ghoneim, A. M., Khattab, A. E. (2014). Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations. J. Braz. Chem. Soc., 25 (8), 1407 – 1418.

Cardoso S. G., Ieggli, C. V., Pomblum, S. C. (2007). Spectrophotometric determination of carvedilol in pharmaceutical formulations through charge-transfer and ion-pair complexation reactions. Pharmazie, 62 (1), 34–37.

Gudruman, A. D., Murăraşu, A., Dorneanu, V. (2012). Spectrophotometric determination of bisoprolol using methyl orange as reagent. FARMACIA, 60 (5), 634–641. Available at: http://www.revistafarmacia.ro/201205/art5.gudruman.pdf

Patel, N. D., Captain, A. D. (2013). Extractive spectrophotometric method for simultaneous determination of losartan potassium and atenolol in bulk and in pharmaceutical dosage form. International Journal of PharmTech Research CODEN (USA), 5 (2), 629–640.

Zhuk, Ju. M., Vasjuk, S. O., Kejtlіn, І. M. (2012). Spektrofotometrichne viznachennja bіsoprololu za reakcіeju z timolovim sinіm. Zaporozhskij medicinskij zhurnal, 3 (72), 62–64.

Publié-e

2015-10-30

Numéro

Rubrique

Pharmaceutical Sciences