Методи ідентифікації та кількісного визначення Β-адреноблокаторів (огляд літератури)

Автор(и)

  • Ольга Олександрівна Віслоус Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Україна
  • Наталія Юріївна Бевз Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Україна
  • Вікторія Акопівна Георгіянц Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002, Україна

DOI:

https://doi.org/10.15587/2313-8416.2015.52357

Ключові слова:

артеріальна гіпертензія, фармацевтичний аналіз, β-адреноблокатори, спектрофотометрія, хроматографія, субстанція, лікарські форми

Анотація

Кількість β-адреноблокаторів на фармацевтичному ринку з кожним роком збільшується, що потребує систематизації методик їх стандартизації.

Мета. Метою наших досліджень є вивчення літературних даних щодо методик ідентифікації та кількісного визначення β-адреноблокаторів різної направленості дії – селективної (практолол, метопролол, атенолол, ацебутолол, бетаксолол, бевантолол, бісопролол, целіпролол, есмолол, епанолол, есатенолол, небіволол, талінолол), неселективної (алпренолол, окспренолол, піндолол, пропранолол, тимолол, соталол, надолол, мепіндолол, картеол, тертатолол, бопіндолол, бупранолол, пенбутолол, клоранолол) та комбінованої (лабеталол, карведілол).

Методи. Аналітичний огляд літературних джерел інформації щодо дослідження β-адреноблокаторів фізичними, хімічним та фізико-хімічним методами аналізу.

Результати. У результаті аналізу літературних джерел встановлено, що для ідентифікації БАБ у фармакопейному аналізі в основному застосовують фізичні та фізико-хімічні константи, у судовому аналізі – як фізико-хімічні величини, так і хімічні реакції, результати яких наведені в роботі.

Встановлено, що для кількісної оцінки БАБ в аналізі субстанцій використовують титриметричні методи, найчастіше метод кислотно-основного титрування. Для виявлення β-адреноблокаторів у біологічних рідинах та лікарських формах, розділення суміші активних фармацевтичних інгредієнтів та метаболітів перевагу слід віддати фізико-хімічним методам, таким як газорідинна і рідинна хроматографія, абсорбційна спектрофотометрія в ультрафіолетовій та видимій областях, флюорометрія та інш.

Висновки. Приведені дані можуть бути застосовані для подальшого пошуку оптимальних методик ідентифікації та кількісного визначення β-адреноблокаторів як чистому вигляді, так і в суміші з іншими діючими та допоміжними речовинами

Біографії авторів

Ольга Олександрівна Віслоус, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Здобувач

Кафедра фармацевтичної хімії 

Наталія Юріївна Бевз, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Кандидат фармацевтичних наук, доцент

Кафедра фармацевтичної хімії 

Вікторія Акопівна Георгіянц, Національний фармацевтичний університет вул. Пушкінська, 53, м. Харків, Україна, 61002

Доктор фармацевтичних наук, професор

Кафедра фармацевтичної хімії 

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2015-10-30

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