DOI: https://doi.org/10.26641/2307-0404.2017.2.109707

Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes.

O. L. Apykhtina, K. P. Kozlov

Abstract


The article presents the results of study of cadmium accumulation in the internal organs of Wistar rats after prolonged intraperitoneal administration of cadmium chloride and cadmium sulphide nanoparticles of 4-6 nm and 9-11 nm in size in a dose of 0.08 mg /kg/day calculated as cadmium. Toxic effects were evaluated after 30 injections (1.5 months), 60 injections (3 months), and 1.5 months after the exposure has been ceased. The results of the study showed that the most intensive accumulation of cadmium was observed in the kidneys and liver of experimental animals, which is due to the peculiarities of the toxicokinetics and the route of administration of cadmium compounds. In the kidneys, spleen and thymus of animals exposed to cadmium sulphide nanoparticles, a greater concentration of cadmium than in the organs of animals exposed to cadmium chloride was found. Cadmium accumulated more intensively in the spleen after exposure to larger nanoparticles, than in the kidneys and thymus. In the liver, heart, aorta and brain significant accumulation was observed after cadmium chloride exposure.

 


Keywords


nanoparticles; cadmium; toxicity; content in internal organs

Full Text:

PDF

References


Adams SV,PassarelliMN, Newcomb PA. Cad­mium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. Occup­ational and Environmental Medicine. 2012;69(2):153-6.

Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF. Cadmium-induced Cancers in Animals and in Humans. International Journal of Occupational and Environmental Health. 2007;13(2):202-12.

He L, Wang B, Hay EB, Nebert DW. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicology and Applied Pharmacology. 2009;238:250-7.

Liu L, Sun M, Li Q, Zhang H, Alvarez PJ, Liu H, Chen W. Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots. Environmental Engineering Science. 2014;31(7):373-80.

Jarup L, Berglund M, Elinder C, Nordberg G and Vahteram M. Health effects of cadmium exposure – a review of the literature and a risk estimate. Scandinavian Journal of Work, Environment & Health. 1998;1:1-52.

Jie Liu, Wei Qu,KadiiskaMB. Role of oxidative stress in cadmium toxicity and carcinogenesis. To­xico­logy and Applied Pharmacology. 2009;238(3):209-214.

KozhevnikovaNS, Vorokh AS, Uritskaya AA. Ca­dmium sulfide nanoparticles prepared by chemical bath de­position. Russian Chemical Reviews. 2015;84(3):225-50.

Åkesson A, Barregard L, Bergdahl IA, Nordberg GF, Nordberg M, Skerfving S. Non-renal effects and the risk assessment of environmental cadmium exposure. Environmental Health Perspectives. 2014;122(5):431-8. doi: 10.1289/ehp.1307110.

Prozialeck WC, Edwards JR. Early biomarkers of cadmium exposure and nephrotoxicity. Biometals. 2010;23(5):793-809. doi: 10.1007/s10534-010-9288-2.

Prozialeck WC, Edwards R. Mechanisms of Cad­mium-Induced Proximal Tubule Injury: New Insights with Implications for Biomonitoring and Therapeutic In­terventions. Journal of Pharmacology and Experimental The­rapeutics. 2012;343(1);2–12. doi: 10.1124/jpet.110.166769.

Godt J, Scheidig F, Grosse-Siestrup C, Esche V,BrandenburgP, Reich A, Groneberg DA. The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology. 2006;1:22. doi: 10.1186/1745-6673-1-22.

Thévenod F, Lee WK. Toxicology of cadmium and its damage to mammalian organs. Metal Ions in Life Scien­ces. 2013;11:415-90. doi: 10.1007/978-94-007-5179-8_14.

Wang B, Du Y. Cadmium and its neurotoxic effects. Oxidative Medicine and Cellular Longevity. 2013;898034. doi: 10.1155/2013/898034.


GOST Style Citations


  1. Adams S.V. Cadmium exposure and cancer mor­tality in the Third National Health and Nutrition Examina­tion Survey cohort / S.V. Adams, M.N. Passarelli, P.A. Newcomb // Occupational Environmental Med. – 2012. – Vol. 69, N 2. – P. 153-156.
  2. Cadmium-induced Cancers in Animals and in Hu­mans / J. Huff, R.M. Lunn, M.P. Waalkes [et al.] // Inter. J. Occupational Environmental Health. – 2007. – Vol. 13, N 2. – P. 202-212.
  3. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney / L. He, B. Wang, E.B. Hay, D.W. Nebert // Toxicol. Applied Pharmacol. – 2009. – Vol. 238. – P. 250-257.
  4. Genotoxicity and Cytotoxicity of Cadmium Sul­fide Nanomaterials to Mice: Comparison Between Nano­rods and Nanodots / L. Liu, M. Sun, Q. Li [et al.] // Envi­ronmental Engineering Science. – 2014. – Vol. 31, N 7. – P. 373-380.
  5. Health effects of cadmium exposure – a review of the literature and a risk estimate / L. Jarup, M. Berglund, C. Elinder [et al.] // Scandinav. J. Work, Environment & Health. – 1998. – N 1. – P. 1-52.
  6. Jie Liu. Role of oxidative stress in cadmium toxicity and carcinogenesis /, Wei Qu, M.B. Kadiiska // Toxicol. Appl. Pharmacol. – 2009. – Vol. 238, N 3.– P. 209-214.
  7. Kozhevnikova N.S. Cadmium sulfide nanopar­ticles prepared by chemical bath deposition / N.S. Kozhe­vnikova, A.S. Vorokh, A.A. Uritskaya // Russian Che­mical Reviews. – 2015. – Vol. 84, N 3. – P. 225-250.
  8. Non-renal effects and the risk assessment of environmental cadmium exposure / A. Åkesson, L. Bar­regard, I.A. Bergdahl [et al.] // Environmental Health Perspect. – 2014. – Vol. 122, N 5. – P. 431-438.
  9. Prozialeck W.C. Early biomarkers of cadmium exposure and nephrotoxicity / W.C. Prozialeck, J.R. Ed­wards // Biometals. – 2010. – Vol. 23, N 5. – P. 793-809.
  10. Prozialeck W.C. Mechanisms of Cadmium-In­duced Proximal Tubule Injury: New Insights with Implications for Biomonitoring and Therapeutic In­ter­ventions / W.C. Prozialeck, J.R. Edwards // J. Pharma­cology Experim. Ther. – 2012. – Vol. 343, N 1. – P. 2-12.
  11. The toxicity of cadmium and resulting hazards for human health / J. Godt, F. Scheidig, C. Grosse-Siestrup [et al.] // J. Occupational Med. Toxicol. – 2006. – N 1. – P. 22-28.
  12. Thévenod F. Toxicology of cadmium and its da­mage to mammalian organs / F. Thévenod, W.K. Lee // Metal Ions in Life Sciences. – 2013. – Vol. 11. – P. 415-490.
  13. Wang B. Cadmium and its neurotoxic effects / B. Wang, Y. Du // Oxidative Med. Cell. Longevity. – 2013. – 898034. 


 

Cited-by:

1. THE INFLUENCE OF HEAVY METALS ON THE MORPHOFUNCTIONAL STATE OF THE HEART (REVIEW ARTICLE)
O. Nefedova, I. Zadesenets
Bulletin of Problems Biology and Medicine  Vol: 1.2  Issue: 144  First page: 31  Year: 2018  
doi: 10.29254/2077-4214-2018-1-2-143-31-35



 

This work is licensed under a Creative Commons Attribution 4.0 International License