Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes.

Authors

  • O. L. Apykhtina
  • K. P. Kozlov

DOI:

https://doi.org/10.26641/2307-0404.2017.2.109707

Keywords:

nanoparticles, cadmium, toxicity, content in internal organs

Abstract

The article presents the results of study of cadmium accumulation in the internal organs of Wistar rats after prolonged intraperitoneal administration of cadmium chloride and cadmium sulphide nanoparticles of 4-6 nm and 9-11 nm in size in a dose of 0.08 mg /kg/day calculated as cadmium. Toxic effects were evaluated after 30 injections (1.5 months), 60 injections (3 months), and 1.5 months after the exposure has been ceased. The results of the study showed that the most intensive accumulation of cadmium was observed in the kidneys and liver of experimental animals, which is due to the peculiarities of the toxicokinetics and the route of administration of cadmium compounds. In the kidneys, spleen and thymus of animals exposed to cadmium sulphide nanoparticles, a greater concentration of cadmium than in the organs of animals exposed to cadmium chloride was found. Cadmium accumulated more intensively in the spleen after exposure to larger nanoparticles, than in the kidneys and thymus. In the liver, heart, aorta and brain significant accumulation was observed after cadmium chloride exposure.

 

Author Biographies

O. L. Apykhtina

SI «Institute for Occupational Health of AMS of Ukraine»
laboratory of industrial toxicology and occupational hygiene when using chemicals
Saksaganskogo str., 75, Kyiv, Ukraine

K. P. Kozlov

SI «Institute for Occupational Health of AMS of Ukraine»
laboratory of industrial toxicology and occupational hygiene when using chemicals
Saksaganskogo str., 75, Kyiv, Ukraine

References

Adams SV,PassarelliMN, Newcomb PA. Cad­mium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. Occup­ational and Environmental Medicine. 2012;69(2):153-6.

Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF. Cadmium-induced Cancers in Animals and in Humans. International Journal of Occupational and Environmental Health. 2007;13(2):202-12.

He L, Wang B, Hay EB, Nebert DW. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicology and Applied Pharmacology. 2009;238:250-7.

Liu L, Sun M, Li Q, Zhang H, Alvarez PJ, Liu H, Chen W. Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots. Environmental Engineering Science. 2014;31(7):373-80.

Jarup L, Berglund M, Elinder C, Nordberg G and Vahteram M. Health effects of cadmium exposure – a review of the literature and a risk estimate. Scandinavian Journal of Work, Environment & Health. 1998;1:1-52.

Jie Liu, Wei Qu,KadiiskaMB. Role of oxidative stress in cadmium toxicity and carcinogenesis. To­xico­logy and Applied Pharmacology. 2009;238(3):209-214.

KozhevnikovaNS, Vorokh AS, Uritskaya AA. Ca­dmium sulfide nanoparticles prepared by chemical bath de­position. Russian Chemical Reviews. 2015;84(3):225-50.

Åkesson A, Barregard L, Bergdahl IA, Nordberg GF, Nordberg M, Skerfving S. Non-renal effects and the risk assessment of environmental cadmium exposure. Environmental Health Perspectives. 2014;122(5):431-8. doi: 10.1289/ehp.1307110.

Prozialeck WC, Edwards JR. Early biomarkers of cadmium exposure and nephrotoxicity. Biometals. 2010;23(5):793-809. doi: 10.1007/s10534-010-9288-2.

Prozialeck WC, Edwards R. Mechanisms of Cad­mium-Induced Proximal Tubule Injury: New Insights with Implications for Biomonitoring and Therapeutic In­terventions. Journal of Pharmacology and Experimental The­rapeutics. 2012;343(1);2–12. doi: 10.1124/jpet.110.166769.

Godt J, Scheidig F, Grosse-Siestrup C, Esche V,BrandenburgP, Reich A, Groneberg DA. The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology. 2006;1:22. doi: 10.1186/1745-6673-1-22.

Thévenod F, Lee WK. Toxicology of cadmium and its damage to mammalian organs. Metal Ions in Life Scien­ces. 2013;11:415-90. doi: 10.1007/978-94-007-5179-8_14.

Wang B, Du Y. Cadmium and its neurotoxic effects.https://www.ncbi.nlm.nih.gov/pubmed/23997854"> Oxidative Medicine and Cellular Longevity. 2013;898034. doi: 10.1155/2013/898034.

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Published

2017-07-29

How to Cite

1.
Apykhtina OL, Kozlov KP. Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes. Med. perspekt. [Internet]. 2017Jul.29 [cited 2024Nov.22];22(2):4-9. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/109707

Issue

Vol. 22 No. 2 (2017)

Section

THEORETICAL MEDICINE

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