Neutrophil-to-lymphocyte ratio in predicting prognosis and course of community community-acquired pneumonia in hospitalized patients.

Authors

  • T. O. Pertseva
  • T. V. Kirieieva
  • K. O. Bielosludtseva
  • M. A. Krykhtina

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127249

Keywords:

community acquired pneumonia, NLR, disease severity, mortality prediction

Abstract

Currently, a marker which could be used both to assess the severity of community acquired pneumonia (CAP) and determine the risk of complications is being searched. According to some authors, Neutrophil-to-Lymphocyte Ratio (NLR) could be such a marker. Therefore, the aim of our research was to determine the diagnostic significance of NLR in patients with CAP and to establish the relationship of NLR with other clinical and laboratory parameters. We conducted a retrospective analysis of 171 case histories of patients with CAP of 3 and 4 clinical groups, with the calculation of NLR (according to the common blood count). In the course of the work, it was found that NLR reflects a balance between the response of neutrophils and lymphocytes and this parameter is associated with the severity of systemic inflammation in patients with CAP. NLR has good diagnostic value in determining the mortality risk in patients with CAP, specially an increase in the level of NLR (more than 10) is associated with a high risk of life-threatening complications.

Author Biographies

T. O. Pertseva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

T. V. Kirieieva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

K. O. Bielosludtseva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

M. A. Krykhtina

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of internal medicine 1
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

References

[About the approval of clinical protocols for the provision of medical care in the specialty "Pulmonology": Order of the Ministry of Health of Ukraine N 128 dated March 19, 2007]. Kyiv. 2007;146. Ukrainian.

Rebrova OYu. [Statistical analysis of medical data. Application package STATISTICA]. MedyaSfera, 2002;312. Russian.

RumiantsevPO. [Statistical methods of analysis in clinical practice.PartI.One-Dimensional Statistical Analysis]. Problemy endokrinologii. 2009;55(5):48-55. Ukrainian.

Khalafian AA. [STATISTICА 6. Statistical ana­lysis of data]. OOO «Bynom-Press», 2007;512. Russian.

Birnbaumer DM. SMART-COP: A Better Pneu­monia Stratification Score? Journal Watch Emergency Medicine. 2008;1:375.

de Jager CPC, Wever PC, Gemen EFA. The Neu­tro­phil-Lymphocyte Count Ratio in Patients with Com­munity-Acquired Pneumonia. Eberl M. J. Plos One. 2012;7:e46561.

Cataudella E, Giraffa CM, Di Marca S. Neutro­phil-To-Lymphocyte Ratio: An Emerging Marker Predic­ting Prognosis in Elderly Adults with Community-Acqui­red Pneumonia. J Am Geriatr Soc. 2017;65(8):1796-801.

Cornelis PC, Peter CW, Eugenie FA. The Neu­trophil-Lymphocyte Count Ratio in Patients with Com­munity-Acquired Pneumonia. J. Plos. 2012;0046561 7(10):e46561.

Curbelo J, Bueno SL, Galván-Román JM. Inflam­mation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio. J. Plos One. 2017;12(3):e0173947.

Martinez R, Menendez R, Reyes S, Polverino E, Cilloniz C, et al. Factors associated with inflammatory cy­tokine patterns in community-acquired pneumonia. Eur Respir J. 2011;37:393-9

Schuetz P, Wolbers M, Christ-Crain M, Thomann R. Prohormones for prediction of adverse medical out­come in community-acquired pneumonia and lower res­piratory tract infections. Crit Care 2010;14:R106.

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How to Cite

1.
Pertseva TO, Kirieieva TV, Bielosludtseva KO, Krykhtina MA. Neutrophil-to-lymphocyte ratio in predicting prognosis and course of community community-acquired pneumonia in hospitalized patients. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Apr.24];23(1(part1):117-22. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127249

Issue

Vol. 23 No. 1(part1) (2018)

Section

CLINICAL MEDICINE

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