Neutrophil-to-lymphocyte ratio in predicting prognosis and course of community community-acquired pneumonia in hospitalized patients.
DOI:
https://doi.org/10.26641/2307-0404.2018.1(part1).127249Ключевые слова:
community acquired pneumonia, NLR, disease severity, mortality predictionАннотация
Currently, a marker which could be used both to assess the severity of community acquired pneumonia (CAP) and determine the risk of complications is being searched. According to some authors, Neutrophil-to-Lymphocyte Ratio (NLR) could be such a marker. Therefore, the aim of our research was to determine the diagnostic significance of NLR in patients with CAP and to establish the relationship of NLR with other clinical and laboratory parameters. We conducted a retrospective analysis of 171 case histories of patients with CAP of 3 and 4 clinical groups, with the calculation of NLR (according to the common blood count). In the course of the work, it was found that NLR reflects a balance between the response of neutrophils and lymphocytes and this parameter is associated with the severity of systemic inflammation in patients with CAP. NLR has good diagnostic value in determining the mortality risk in patients with CAP, specially an increase in the level of NLR (more than 10) is associated with a high risk of life-threatening complications.
Библиографические ссылки
[About the approval of clinical protocols for the provision of medical care in the specialty "Pulmonology": Order of the Ministry of Health of Ukraine N 128 dated March 19, 2007]. Kyiv. 2007;146. Ukrainian.
Rebrova OYu. [Statistical analysis of medical data. Application package STATISTICA]. MedyaSfera, 2002;312. Russian.
RumiantsevPO. [Statistical methods of analysis in clinical practice.PartI.One-Dimensional Statistical Analysis]. Problemy endokrinologii. 2009;55(5):48-55. Ukrainian.
Khalafian AA. [STATISTICА 6. Statistical analysis of data]. OOO «Bynom-Press», 2007;512. Russian.
Birnbaumer DM. SMART-COP: A Better Pneumonia Stratification Score? Journal Watch Emergency Medicine. 2008;1:375.
de Jager CPC, Wever PC, Gemen EFA. The Neutrophil-Lymphocyte Count Ratio in Patients with Community-Acquired Pneumonia. Eberl M. J. Plos One. 2012;7:e46561.
Cataudella E, Giraffa CM, Di Marca S. Neutrophil-To-Lymphocyte Ratio: An Emerging Marker Predicting Prognosis in Elderly Adults with Community-Acquired Pneumonia. J Am Geriatr Soc. 2017;65(8):1796-801.
Cornelis PC, Peter CW, Eugenie FA. The Neutrophil-Lymphocyte Count Ratio in Patients with Community-Acquired Pneumonia. J. Plos. 2012;0046561 7(10):e46561.
Curbelo J, Bueno SL, Galván-Román JM. Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio. J. Plos One. 2017;12(3):e0173947.
Martinez R, Menendez R, Reyes S, Polverino E, Cilloniz C, et al. Factors associated with inflammatory cytokine patterns in community-acquired pneumonia. Eur Respir J. 2011;37:393-9
Schuetz P, Wolbers M, Christ-Crain M, Thomann R. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care 2010;14:R106.
Загрузки
Как цитировать
Выпуск
Раздел
Лицензия
Copyright (c) 2018 Medicni perspektivi
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.