Comparative analysis of vitamin D contents in patients with chronic viral hepatitis C and healthy.

Authors

  • L. L. Shostakovych-Koretskaya
  • M. A. Nikolaychuk
  • I. V. Budayeva
  • O. P. Shevchenko-Makarenko
  • K. Yu. Lytviy
  • S. V. Biletska

DOI:

https://doi.org/10.26641/2307-0404.2019.4.189360

Keywords:

monitoring, chronic hepatitis C, vitamin D deficiency

Abstract

From scientific literature it is known that vitamin D helps maintain the most important functions of the immune system, there is evidence of its role in inflammatory and metabolic diseases of the liver, including infection with hepatitis C. Aim – to study vitamin D status in patients with chronic viral hepatitis C compared to the healthy ones. We examined 100 patients with chronic viral hepatitis C (main group) and 30 patients without hepatitis C virus (control group). Level of 25 (OH) D in serum was studied by immunochemical method with electrochemiluminescent detection. To verify the diagnosis of vitamin D deficiency and insufficiency, a classification (M.F. Holick, 2011), adopted by the International Institute of Medicine and the Committee of Endocrinologists for clinical practice guidelines, was used. Vitamin D deficiency was found in 44% of people with chronic viral hepatitis C in the main group (mean hydroxycalciferol – 14.36±4.12 ng/ml. Vitamin D deficiency was found in 6,6% in the control group (mean 17,5±8,52 ng/ml). The average vitamin D deficiency in the main group was slightly lower than that in the control group. Factors that affect the metabolism of vitamin D in patients with chronic viral hepatitis C include a lack of vitamin D in blood serum.

Author Biographies

L. L. Shostakovych-Koretskaya

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 1
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

M. A. Nikolaychuk

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 1
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

I. V. Budayeva

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 1
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

O. P. Shevchenko-Makarenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 1
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

K. Yu. Lytviy

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 1
Department of Infectious Diseases
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

S. V. Biletska

Medical Center “Unimed” 2
Mlodej Polski str., 7, Krakow, 30-131, Poland

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How to Cite

1.
Shostakovych-Koretskaya LL, Nikolaychuk MA, Budayeva IV, Shevchenko-Makarenko OP, Lytviy KY, Biletska SV. Comparative analysis of vitamin D contents in patients with chronic viral hepatitis C and healthy. Med. perspekt. [Internet]. 2019Dec.26 [cited 2024Mar.29];24(4):94-101. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/189360

Issue

Section

CLINICAL MEDICINE