Comparative analysis of vitamin D contents in patients with chronic viral hepatitis C and healthy.
DOI:
https://doi.org/10.26641/2307-0404.2019.4.189360Ключевые слова:
monitoring, chronic hepatitis C, vitamin D deficiencyАннотация
From scientific literature it is known that vitamin D helps maintain the most important functions of the immune system, there is evidence of its role in inflammatory and metabolic diseases of the liver, including infection with hepatitis C. Aim – to study vitamin D status in patients with chronic viral hepatitis C compared to the healthy ones. We examined 100 patients with chronic viral hepatitis C (main group) and 30 patients without hepatitis C virus (control group). Level of 25 (OH) D in serum was studied by immunochemical method with electrochemiluminescent detection. To verify the diagnosis of vitamin D deficiency and insufficiency, a classification (M.F. Holick, 2011), adopted by the International Institute of Medicine and the Committee of Endocrinologists for clinical practice guidelines, was used. Vitamin D deficiency was found in 44% of people with chronic viral hepatitis C in the main group (mean hydroxycalciferol – 14.36±4.12 ng/ml. Vitamin D deficiency was found in 6,6% in the control group (mean 17,5±8,52 ng/ml). The average vitamin D deficiency in the main group was slightly lower than that in the control group. Factors that affect the metabolism of vitamin D in patients with chronic viral hepatitis C include a lack of vitamin D in blood serum.
Библиографические ссылки
Sergeev IN, Pletsyt KD, Spirichev FI. Receptors of 1,25-dihydroxyvitamin D3 in lymphocytes and the level of T- and B-lymphocytes in patients with glomerulonephritis. Questions of medical chemistry. 1989;36(6):117-21.
Ramagopalan SV, Heger A, Berlanga AJ, et al. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: аassociations with disease and evolution. Genome Research. 2010;20(10):1352-60. doi: https://doi.org/10.1101/gr.107920.110
Brumbaugh PF, Hausler MR. 1a, 25-dihydroxycholecalciferol receptor in intestine. Association with intestinal mucosa chromatin. J. Biol. Chem. 1974;242(4):1251-7.
Clohisy DR, Bar-Schavit Z, Chappel JC, Teitelbaums SL. 1,25-dihydroxyvitamin D modulates bonemazzow macrophage precursor proliferation and differentiation. J. Biol. Chem. 1987;262(33):15922-29.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2011;96(7):1911-30.
Gao L, Tao Y, Zhang L. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and metaanalysis. Int. J. Tuberc. Lung Dis. 2010;14(1):15-23.
Hayes CE, Nashold FE, Spach KM, Pedersen LB. The immunological functions of the vitamin endocrine system. Cell. Mol. Biol. 2003;49(2):277-300.
Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81. PubMed. Google Scholar. doi: https://doi.org/10.1056/NEJMra070553
Morgan JM, Konttab N, Ford AL. Mairel Vitamin D-mediated gene regulation in phenotypically defined human B cell subpopulations. Endocrinology. 2000;141(9):3225-34. doi: https://doi.org/10.1210/en.141.9.3225
Berer A, Stockl J, Majdic O, et al. 1,25-dihydroxyvitamin D3 inhibits dendritic cell differentiation and maturation in vitro. Exp. Hematol. 2000;28(5):575-583. doi: https://doi.org/10.1016/S0301-472X(00)00143-0
Pang Q, Qu K, Zhang J-Y, Liu C. Evidence supporting a beneficial role of vitamin D in chronic hepatitis C, Journal of Hepatology; 2015. doi: http://dx.doi.org/10.1016/j.jhep.2015.03.037
Penna G, Adorini L. 1 alfa, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation. J. Immunol. 2000;164(5):2405-11. doi: https://doi.org/10.4049/jimmunol.164.5.2405
Pizas JE, Turner RT, Howard GA, Baylink DJ. Cell isolated from embryonic intestinal synthesizes 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in culture. Endocrinolody. 1983;112(1):378-380. doi: https://doi.org/10.1210/endo-112-1-378
Takuya M, Takanobu K, Nao S, Megumi T, Asako M, Takahiro M, et al. 25-hydroxyvitamin D3 suppresses hepatitis C virus production. J. Hepatol. 2012;56:1231-9. doi: https://doi.org/10.1002/hep.25763
Villar LM, Del Campo JA, Ranchal I. Association between vitamin D and hepatitis C virus infection: a meta-analysis. World J. Gastroenterol. 2013;19(35):5917-24. doi: https://doi.org/10.3748/wjg.v19.i35.5917
Bitetto D, Fabris C, Fornasiere E, Pipan C, Fumolo E, Cussigh A. et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. Transplant. Int. 2010;24:43-50. doi: https://doi.org/10.1111/j.1432-2277.2010.01141.x
Piemonti L, Monti P, Sironi M, et al. Vitamin D3 affects differentiation, maturation and faction of human monocyte derived dendritie cells. J. Immunol. 2000;164(9):4443-51. doi: https://doi.org/10.4049/jimmunol.164.9.4443
Yamshchikov AV, Desai N, Blumberg H. Vitamin D for treatment and prevention of infectious diseases: asystematic review of randomized controlled trials. Endocr. Pract. 2009;15:(5):438-49. doi: doi.org/10.4158/EP09101.ORR
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